Hydrophilic fluid transport device
View Patent ↗Hydrophilic articles and methods of using such articles are described. The hydrophilic articles include a hydrophilic layer comprising sintered, acidified silica nanoparticles attached to a substrate. A spacer layer attached to a first portion of the hydrophilic layer defines at least one fluid transport channel bounded on one side by a second portion of the hydrophilic layer. The nanoparticles may include one or both of spherical and elongated nanoparticles.
1. A hydrophilic article comprising a substrate, a first surface of a hydrophilic layer comprising sintered, acidified silica nanoparticles attached to the substrate, and a spacer layer attached to a first portion of a second surface of the hydrophilic layer opposite the first surface, wherein the spacer layer defines at least one fluid transport channel bounded on one side by a second portion of the second surface of the hydrophilic layer, wherein the nanoparticles comprise elongated silica nanoparticles having an average length to diameter ratio of at least 2, and wherein the hydrophilic layer is substantially surfactant-free.
2. The hydrophilic article of claim 1 , wherein the hydrophilic layer comprises no greater than 0.001 weight percent surfactant, based on the total weight of the hydrophilic layer.
3. The hydrophilic article of claim 2 , wherein the hydrophilic layer comprises no greater than 0.0005 weight percent surfactant, based on the total weight of the hydrophilic layer.
4. The hydrophilic article according to claim 1 , wherein the fluid transport channel comprises a landing zone comprising an exposed portion of the hydrophilic layer.
5. The hydrophilic article of claim 4 , wherein the landing zone is located at an edge of the substrate.
6. The hydrophilic article according to claim 1 , wherein the fluid transport channel comprises a detection zone comprising a portion of the hydrophilic layer that is (i) exposed or (ii) covered by a layer having a transmissivity of at least 50% for at least one wavelength of electromagnetic energy between 200 and 800 nm, inclusive.
7. The hydrophilic article according to claim 6 , wherein the article comprises the landing zone, and wherein the detection zone is in fluid communication with the landing zone via the transport channel.
8. The hydrophilic article according to claim 1 , further comprising a cover layer in contact with at least a portion of a surface of the spacer layer opposite the hydrophilic layer and covering at least a portion of the fluid transport channel.
9. The hydrophilic article of claim 8 , wherein the cover layer comprises a second hydrophilic layer comprising sintered, acidified silica nanoparticles attached to a second substrate.
10. The hydrophilic article of claim 8 , wherein the cover layer is integral with the spacer layer.
11. The hydrophilic article of claim 1 , wherein the average length to diameter ratio of the elongated silica nanoparticles is 3 to 15.
12. The hydrophilic article according to claim 1 , wherein the nanoparticles comprise 50 to 95 weight percent substantially spherical silica nanoparticles having a ratio of maximum diameter to minimum diameter of less than 2, and 5 to 50 parts by weight elongated silica nanoparticles having an average length to diameter ratio of at least 2, based on the total weight of the nanoparticles.
13. The hydrophilic article of claim 12 , wherein the ratio of maximum diameter to minimum diameter of the substantially spherical silica nanoparticles is less than 1.2 and the average length to diameter ratio of the elongated silica nanoparticles is 3 to 15.
14. The hydrophilic article of claim 13 , wherein the nanoparticles comprise 60 to 80 weight percent of the substantially spherical nanoparticles and 20 to 40 parts by weight of the elongated nanoparticles, based on the total weight of the nanoparticles.
15. The hydrophilic article according to claim 1 , wherein the hydrophilic layer comprises at least 95 weight percent of the nanoparticles, based on the total weight of the hydrophilic layer.
16. The hydrophilic article of claim 15 , wherein the hydrophilic layer comprises no greater than 2 weight percent resin, based on the total weight of the hydrophilic layer.
17. The hydrophilic article according to claim 16 , wherein the hydrophilic layer consists essentially of the nanoparticles.
18. A method of transporting a fluid with the hydrophilic article according to claim 1 comprising: applying the fluid to a first region of the second portion of the second surface of the hydrophilic layer and wicking the fluid within the fluid transport channel from the first region to a second region of the second portion of the second surface of the hydrophilic layer.
19. The method of claim 18 , wherein the fluid is a biological fluid.