Granted Patent B2

US 9,457,024 · App. 14/356,486 · Granted Oct 4, 2016

Abstract

Claims (22)

1. A composition comprising:

a non-steroidal anti-inflammatory drug (NSAID); and

an opioid agonist compound of formula:

and pharmaceutically acceptable salts thereof, wherein:

R 1 is hydrogen or methyl;

R 2 is hydrogen or hydroxyl;

R 3 is hydrogen, methyl, or cyclobutylmethyl;

R 4 is hydrogen;

“———” represents an optional double bond;

Y 1 is O;

X is a physiologically stable linker;

n is an integer from 1 to 10; and

Y is lower alkyl.

2. The composition of claim 1 , wherein the opioid agonist compound is:

and pharmaceutically acceptable salts thereof.

3. The composition of claim 1 , wherein the opioid agonist compound is of the formula:

wherein n is an integer selected from 2 to 10; and pharmaceutically acceptable salts thereof.

4. The composition of claim 1 , wherein the non-steroidal anti-inflammatory drug (NSAID) is ketorolac, ibuprofen, oxaprozin, indomethecin, etodolac, meloxicam, sulindac, diclofenac, flufenamic acid, difunisal, naproxen, flurbiprofen, ketoprofen, fenoprofen, or acetaminophen.

5. The composition of claim 1 in a unit dosage form.

6. The composition of claim 1 , wherein a non-steroidal anti-inflammatory drug (NSAID) is present in the composition.

7. The composition of claim 1 , further comprising at least one pharmaceutically acceptable excipient.

8. A method of treating pain in a patient, comprising administering a composition of claim 1 to a patient in need thereof.

Assignments (10)