2-(1,2,3-triazol-2-yl)benzamide and 3-(1,2,3-triazol-2-YL)picolinamide derivatives as orexin receptor antagonists

1. A compound of formula (I)

wherein

Ar 1 represents a 5- or 6-membered heteroaryl selected from the group consisting of pyrrolyl, pyrazolyl, triazolyl, oxazolyl, thiazolyl, oxadiazolyl, thiophenyl, pyridinyl, pyrimidinyl, pyrazinyl, and pyridazinyl; wherein said heteroaryl is unsubstituted, mono-, or di-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy;

R 1 represents one optional substituent selected from (C 1-4 )alkyl, (C 1-4 )alkoxy, hydroxy, and halogen;

R 2 represents hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, or cyano;

R 3 represents hydrogen, (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 1-3 )fluoroalkyl, or halogen;

R 4 represents hydrogen, (C 1-4 )alkyl, (C 1-3 )fluoroalkyl, or halogen;

R 5 represents one optional substituent on any ring carbon atom of the morpholine ring, wherein said substituent independently is methyl or ethyl; and

Q represents CR 6 ; or, in case R 2 is (C 1-4 )alkyl or (C 1-4 )alkoxy, Q represents CR 6 or N; wherein

R 6 represents hydrogen, fluoro or methyl;

or a pharmaceutically acceptable salt thereof.

2. A compound according to claim 1 ; wherein

the morpholine ring of the compounds of formula (I):

is a ring selected from the group consisting of:

Ar 1 represents a 5- or 6-membered heteroaryl selected from the group consisting of pyrrolyl, pyrazolyl, triazolyl, oxazolyl, thiazolyl, oxadiazolyl, thiophenyl, pyridinyl, pyrimidinyl, pyrazinyl, and pyridazinyl; wherein said heteroaryl is unsubstituted or mono-substituted with (C 1-4 )alkyl;

R 1 represents one optional substituent selected from methyl, methoxy, hydroxy, and halogen;

R 2 represents hydrogen, methyl, methoxy, halogen, or cyano;

R 3 represents hydrogen, methyl, methoxy, trifluoroalkyl, or halogen;

R 4 represents hydrogen, methyl, trifluoroalkyl, or halogen;

Q represents CR 6 ; or, in case R 2 is methyl, Q represents CR 6 or N; wherein

R 6 represents hydrogen, fluoro or methyl;

or a pharmaceutically acceptable salt thereof.

3. A compound according to claim 1 ; wherein Ar 1 represents pyrazol-1-yl, [1,2,3]triazol-2-yl, [1,2,4]oxadiazol-3-yl, and or pyrimidin-2-yl, which groups are unsubstituted, or in case of pyrimidin-2-yl, optionally mono-substituted with methyl; or a pharmaceutically acceptable salt thereof.

4. A compound according to claim 1 ; wherein R 2 represents hydrogen, methyl, methoxy, cyano, fluoro, or chloro; R 3 represents hydrogen, methyl, trifluoromethyl, fluoro, or chloro; R 4 represent hydrogen, methyl, trifluoromethyl, or fluoro; and Q represents CR 6 ; or, in case R 2 is methyl, Q represents CR 6 or N; wherein R 6 represents hydrogen, fluoro or methyl;

or a pharmaceutically acceptable salt thereof.

5. A compound according to claim 1 ; wherein Q represents CH;

or a pharmaceutically acceptable salt thereof.

6. A compound according to claim 1 ; wherein R 2 represents hydrogen or chloro; R 3 represents hydrogen, chloro, methyl or trifluoromethyl, R 4 represent hydrogen or methyl; and Q represents CH;

or a pharmaceutically acceptable salt thereof.

7. A compound according to claim 1 ; wherein the group

is a group independently selected from the following groups A) to F):

or a pharmaceutically acceptable salt thereof.

8. A compound according to claim 1 ; wherein the group

is a group selected from the group consisting of the following groups A) and B):

or a pharmaceutically acceptable salt thereof.

9. A compound according to claim 1 ;

wherein the group

is a group independently selected from the following groups A) to H):

or a pharmaceutically acceptable salt thereof.

10. A compound according to claim 1 ;

wherein the group

is a group selected from the group consisting of the following groups A) and B):

or a pharmaceutically acceptable salt thereof.

11. A compound according to claim 1 selected from the group consisting of:

[(R)-3-(3-[1,2,4]Oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(4-Methoxy-3-pyridin-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-pyridin-3-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-pyrazin-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-pyridazin-3-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-thiazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-oxazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-thiophen-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-[1,2,3]Triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(S)-3-(3-[1,2,3]Triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-pyrazol-1-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-1-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-Pyrazol-1-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-Pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrazol-1-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Fluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrazol-1-yl-benzyl)-morpholin-4-yl]-methanone;

(2-Fluoro-3-methyl-6-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrazol-1-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrazol-1-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]triazol-1-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyridin-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyridin-3-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Fluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyridin-4-yl-benzyl)-morpholin-4-yl]-methanone;

(2-Fluoro-3-methyl-6-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

4-[1,2,3]Triazol-2-yl-3-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholine-4-carbonyl]-benzonitrile;

(5-Methoxy-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(2-Fluoro-3-methoxy-6-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4,5-Dimethoxy-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Fluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrrol-1-yl-benzyl)-morpholin-4-yl]-methanone;

{(R)-3-[3-(4-Methyl-pyrimidin-2-yl)-benzyl]-morpholin-4-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(R)-3-[3-(4-Methyl-pyrimidin-2-yl)-benzyl]-morpholin-4-yl}-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrazin-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-Oxazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-thiazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-Thiazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-thiophen-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-Thiophen-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyridazin-3-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-Pyridazin-3-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(2-Fluoro-3-methyl-6-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Methoxy-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

(6-Methyl-3-[1,2,3]triazol-2-yl-pyridin-2-yl)-[(R)-3-(3-pyrazol-1-yl-benzyl)-morpholin-4-yl]-methanone;

(6-Methyl-3-[1,2,3]triazol-2-yl-pyridin-2-yl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone; and

(3-Fluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

or a pharmaceutically acceptable salt thereof.

12. A compound according to claim 1 selected from the group consisting of:

[(R)-3-(4-Hydroxy-3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Fluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(4-methoxy-3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methoxy-3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(2-methyl-6-[1,2,3]triazol-2-yl-phenyl)-methanone;

(3-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(4-Methyl-3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methyl-3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methyl-3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(3R,5R)-3-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(3R,5R)-3-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(3R,5R)-3-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(3S,5R)-3-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(3S,5R)-3-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(3S,5R)-3-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(3S,5R)-3-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(3,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-[1,2,3]Triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-4-trifluoromethyl-phenyl)-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Fluoro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(4-methyl-3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(4,5-Difluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(3-Fluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(3-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-[1,2,4]Oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-4-trifluoromethyl-phenyl)-methanone;

(5-Fluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(3,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(4-Chloro-3-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Difluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(3,4-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Methoxy-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(3,4-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2S,5R)-2-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-2-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-2-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(3,4-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-2-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(2R,5R)-2-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-2-Methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-Methyl-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-Chloro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(3-Chloro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(3-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(2R,5R)-2-Methyl-5-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-2-Methyl-5-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-2-Methyl-5-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-2-Methyl-5-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(3,4-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-2-methyl-5-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-2-methyl-5-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-2-methyl-5-(3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(2R,5R)-5-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-2-methyl-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-5-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-2-methyl-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-5-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-2-methyl-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-5-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-2-methyl-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Methyl-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Chloro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Methyl-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Chloro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Methyl-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Methyl-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Chloro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Chloro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(2-Fluoro-3-methyl-6-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(2-Fluoro-3-methoxy-6-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(3-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-fluoro-6-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Difluoro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(2-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-4-trifluoromethyl-phenyl)-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(2R,5R)-5-(2-Fluoro-5-[1,2,3]triazol-1-yl-benzyl)-2-methyl-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-5-(2-Fluoro-5-[1,2,3]triazol-1-yl-benzyl)-2-methyl-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-2-Ethyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-2-Ethyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-2-Ethyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(3-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(3-Fluoro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[2R,5R)-5-(2-Fluoro-5-pyrimidin-2-yl-benzyl)-2-methyl-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[2R,5R)-5-(2-Fluoro-5-pyrimidin-2-yl-benzyl)-2-methyl-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[2R,5R)-5-(2-Fluoro-5-pyrimidin-2-yl-benzyl)-2-methyl-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[2R,5R)-5-(2-Fluoro-5-pyrimidin-2-yl-benzyl)-2-methyl-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(3,4-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-5-(2-fluoro-5-pyrimidin-2-yl-benzyl)-2-methyl-morpholin-4-yl]-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-5-(2-fluoro-5-pyrimidin-2-yl-benzyl)-2-methyl-morpholin-4-yl]-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-5-(2-fluoro-5-pyrimidin-2-yl-benzyl)-2-methyl-morpholin-4-yl]-methanone;

(3-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-5-(2-fluoro-5-pyrimidin-2-yl-benzyl)-2-methyl-morpholin-4-yl]-methanone;

[(R)-3-(2-Fluoro-5-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Fluoro-5-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Fluoro-5-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(3,4-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

(3-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(2S,3R)-2-Methyl-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2S,3R)-2-Methyl-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2S,3R)-2-Methyl-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,5R)-5-(2-Fluoro-5-pyridazin-3-yl-benzyl)-2-methyl-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Fluoro-5-pyridazin-3-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,3R)-2-Methyl-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(2R,3R)-2-Methyl-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Chloro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3,4-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Chloro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-chloro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Chloro-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(3-chloro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(3-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-2-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(3-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-5-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-2-methyl-morpholin-4-yl]-methanone;

[(R)-3-(2-Fluoro-5-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Fluoro-5-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(2-Fluoro-5-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(3-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

(3,4-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-fluoro-5-[1,2,4]oxadiazol-3-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(3-[1,2,3]Triazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-3-trifluoromethyl-phenyl)-methanone;

[(R)-3-(2-Fluoro-3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-2-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-2-methyl-5-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-5-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-2-methyl-morpholin-4-yl]-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(2R,5R)-5-(2-fluoro-5-[1,2,3]triazol-2-yl-benzyl)-2-methyl-morpholin-4-yl]-methanone;

[(R)-3-(2-Methyl-5-pyrazol-1-yl-benzyl)-morpholin-4-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Methyl-5-pyrazol-1-yl-benzyl)-morpholin-4-yl]-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(2-Methyl-5-pyrazol-1-yl-benzyl)-morpholin-4-yl]-(3-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(2-methyl-5-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

[(R)-3-(4-Methyl-3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(R)-3-(4-Methyl-3-thiazol-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone; and

[(R)-3-(4-Chloro-3-pyrimidin-2-yl-benzyl)-morpholin-4-yl]-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

or a pharmaceutically acceptable salt thereof.

13. A pharmaceutical composition comprising, as active principle, one or more compounds according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

14. A method of treatment of a disease treatable by antagonizing an orexin receptor, wherein the disease is selected from the group consisting of anxiety disorders, addiction disorders, mood disorders, and appetite disorders; comprising administering to a patient an effective amount of a compound of formula (I) as defined in claim 1 , in free or pharmaceutically acceptable salt form.

15. The compound according to claim 1 which is (4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(R)-3-(3-[1,2,3]triazol-2-yl-benzyl)-morpholin-4-yl]-methanone;

or a pharmaceutically acceptable salt thereof.

16. The compound according to claim 1 , wherein the morpholine ring of the compounds of formula (I):

or a pharmaceutically acceptable salt thereof.

17. A compound according to claim 16 , wherein the group

is a group independently selected from the following groups A) to F):

or a pharmaceutically acceptable salt thereof.

18. A compound according to claim 16 , wherein the group

is a group selected from the group consisting of the following groups A) and B):

or a pharmaceutically acceptable salt thereof.

19. A compound according to claim 17 , wherein the group

is a group independently selected from the following groups A) to H):

or a pharmaceutically acceptable salt thereof.

20. A compound according to claim 18 , wherein the group

is a group selected from the group consisting of the following groups A) and B):

or a pharmaceutically acceptable salt thereof.

21. A pharmaceutical composition comprising, as active principle, the compound according to claim 15 , or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

22. A pharmaceutical composition comprising, as active principle, a compound according to claim 19 , or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

23. A pharmaceutical composition comprising, as active principle, a compound according to claim 20 , or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

24. A method of treatment of a disease treatable by antagonizing an orexin receptor, wherein the disease is selected from the group consisting of anxiety disorders, addiction disorders, mood disorders, and appetite disorders; comprising administering to a patient an effective amount of a compound as defined in claim 20 , in free or pharmaceutically acceptable salt form.

25. A method of treatment of a disease treatable by antagonizing an orexin receptor, wherein the disease is an anxiety disorder or an addiction disorder; comprising administering to a patient an effective amount of the compound of claim 15 , in free or pharmaceutically acceptable salt form.

26. A method of treatment of a circumscribed threat induced anxiety disorder; comprising administering to a patient an effective amount of the compound of claim 15 , in free or pharmaceutically acceptable salt form.

27. The method of claim 26 , wherein the circumscribed threat induced anxiety disorder is a phobic anxiety disorder or a post-traumatic stress disorder.