IP Library Granted Patent US 9,556,176
Granted Patent B2
US 9,556,176 · App. 14/357,495 · Granted Jan 31, 2017

Purine derivatives for the treatment of viral infections

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Quick Facts
Patent No.
US 9,556,176
App. No.
14/357,495
Granted
Jan 31, 2017
Kind
B2
Abstract

The present invention relates to purine derivatives of formula (I), processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.

Claims (8)

1. A compound of formula (I)

or a pharmaceutically acceptable salt, solvate or polymorph thereof, wherein Y is C 1-4 alkylene,

R 1 is selected from the group consisting of imidazolyl, pyrimidyl, pyrrolyl, pyrazolyl, furyl, oxazolyl, oxadiazolyl, isoxazolyl, pyrazinyl and thiazolyl, wherein R 1 is optionally substituted by one or more substituents independently selected from the group consisting of hydroxyl, C 1-6 alkyl, C 1-4 alkoxy, trifluoromethyl, C 3-6 cycloalkyl, phenyl, halogen, hydroxyl-C 1-4 alkyl, C 1-4 -alkoxy-C 1-4 -alkyl- and C 1-4 alkyl-diethoxyphosphoryl R 2 is selected from a group consisting of phenyl, naphtyl, anthracenyl and phenanthrenyl, wherein R 2 is optionally substituted by one or more substituents independently selected from the group consisting of hydroxyl, C 1-6 alkyl, C 1-4 alkoxy, trifluoromethyl, CO 2 R 3 , halogen, hydroxyl-C 1-4 alkyl-, NR 6 R 7 , C(O)R 6 , C(O)NR 6 R 7 , C 1-4 alkyl-diethoxyphosphoryl or C 1-4 alkyl-phosphonic acid;

R 3 is selected from H and C 1-6 alkyl;

R 6 and R 7 are each independently selected from H, C 1-6 alkyl or C 1-4 alkoxy—after C 1-4 alkyl-diethoxyphosphoryl.

2. A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof according to claim 1 , together with one or more pharmaceutically acceptable excipients, diluents or carriers.

3. A compound selected from the group consisting of:

4. A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, solvate or polymorph thereof according to claim 3 , together with one or more pharmaceutically acceptable excipients, diluents or carriers.

Assignments (7)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2015
From: JANSSEN R & D IRELAND
To: JANSSEN SCIENCES IRELAND UC
Reel/Frame 035496/0382 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2014
From: JANSSEN-CILAG
To: JANSSEN R&D IRELAND
Reel/Frame 033022/0692 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2014
From: EMBRECHTS, WERNER
To: JANSSEN PHARMACEUTICA NV
Reel/Frame 033022/0729 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2014
From: BONFANTI, JEAN-FRANCOIS; DOUBLET, FREDERIC MARC MAURICE; FORTIN, JEROME MICHEL CLAUDE; MULLER, PHILIPPE
To: JANSSEN-CILAG
Reel/Frame 033022/0659 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2014
From: MC GOWAN, DAVID CRAIG; RABOISSON, PIERRE JEAN-MARIE BERNARD
To: JANSSEN INFECTIOUS DISEASES - DIAGNOSTICS BVBA
Reel/Frame 033022/0797 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2014
From: JANSSEN INFECTIOUS DISEASES - DIAGNOSTICS BVBA
To: JANSSEN R&D IRELAND
Reel/Frame 033022/0873 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 3, 2014
From: JANSSEN PHARMACEUTICA NV
To: JANSSEN R&D IRELAND
Reel/Frame 033022/0774 →