Controlled stimulation delivery from neurostimulator
View Patent ↗A system for providing neurostimulation includes an external device (“external exciter”) and an implanted device. The external exciter includes an energy source which inductively powers the implanted device. Examples of such external exciters include devices having at least one of: ultrasonic transducers, Radio Frequency (RF) transmitters, and solar cells. The implanted device includes circuitry that limits its maximum energy output to a predetermined saturation threshold such that excess stimulation from the external exciter does not raise the output of the implanted device beyond the saturation threshold. The output signal of the external exciter is then pulse-width modulated in order to produce a desired amount of output stimulation from the implanted device to stimulate the bioelectrically excitable tissue at a desired level.
1. A method of stimulating an electrode configured to deliver an electrical stimulation to tissue of a subject, comprising:
placing an exciter in spatial proximity to an implantable device, the implantable device including:
an energy acquisition device;
a voltage limiting device connected to the energy acquisition device;
an electrode connected to the voltage limiting device;
providing instructions to an exciter to radiate a pulse-width modulated output excitation signal directed at the implantable device;
measuring a first harmonic signal, a second harmonic signal, and a third harmonic signal;
determining a magnitude of the pulse-width modulated output excitation signal required to cause the energy acquisition device to enter into a voltage saturation state based on the first, second, and third harmonic signals; and
applying the pulse-width modulated output excitation signal that has a magnitude that is at least as large as the determined magnitude.
2. The method of claim 1 , wherein the energy acquisition device includes at least one of a dipole antenna and a piezoelectric material.
3. The method of claim 1 , wherein the exciter includes at least one of a radio frequency transmitter, an ultrasound emitter, and a photic energy emitter.
4. The method of claim 1 , wherein the voltage limiting device includes at least one of a Zener diode, a silicon diode, and a metal oxide varistor.
5. The method of claim 1 , wherein the exciter includes at least one of a radio frequency transmitter, an ultrasound emitter, and a photic energy emitter.
6. The method of claim 1 , wherein the excitation signal includes a plurality of neurostimulation pulses having a duration of approximately 50 microseconds, each neurostimulation pulse including a plurality of subpulses, each subpulse having a duration of approximately 5 microseconds to 10 microseconds.
7. The method of claim 1 , wherein the pulse-width modulated output excitation signal has a magnitude selected to cause the implantable device to enter a voltage saturation state when a duty cycle of the excitation signal is approximately 100%.