IP Library › Granted Patent US 9,642,896
Granted Patent B1
US 9,642,896 · App. 14/358,166 · Granted May 9, 2017

Compositions and methods for modulating coagulation

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Quick Facts
Patent No.
US 9,642,896
App. No.
14/358,166
Granted
May 9, 2017
Kind
B1
Abstract

The present invention relates to compositions and methods for modulating coagulation through modulating the level or activity of NPP4.

Claims (7)

1. A method of treating bleeding or coagulopathy in a human subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an isolated soluble NPP4 polypeptide comprising amino acid residues 1-407 of SEQ ID NO:1.

2. The method of claim 1 , wherein the NPP4 polypeptide is a recombinant NPP4 polypeptide.

3. The method of claim 1 , wherein the NPP4 polypeptide lacks the NPP4 transmembrane domain.

4. The method of claim 1 , wherein the NPP4 polypeptide consists of amino acid residues 1-407 of SEQ ID NO:1.

5. The method of claim 1 , wherein the NPP4 polypeptide is administered in combination with at least one other agent useful in treating bleeding.

6. The method of claim 1 , wherein the NPP4 polypeptide is administered acutely or chronically.

7. The method of claim 1 , wherein the NPP4 polypeptide is administered locally, regionally or systemically.

Assignments (2)
SECURITY INTEREST Recorded Apr 27, 2026
From: BIOMARIN PHARMACEUTICAL INC.; AMICUS THERAPEUTICS, INC.
To: CITIBANK, N.A., AS COLLATERAL AGENT
Reel/Frame 075493/0968 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2014
From: BRADDOCK, DEMETRIOS; ALBRIGHT, RONALD
To: YALE UNIVERSITY
Reel/Frame 032887/0684 →