Anti-microbial peptides and methods of use thereof
View Patent ↗Anti-microbial peptides and methods of use are provided.
1. An isolated anti-microbial peptide comprising the amino acid sequence GX 1 KRLVQRLKDX 2 LRNLV (SEQ ID NO: 58), wherein X 1 and X 2 are any amino acid.
2. The isolated anti-microbial peptide of claim 1 , consisting of SEQ ID NO: 58.
3. The isolated anti-microbial peptide of claim 1 , wherein the Leu at positions 5, 9, and 13 are D-amino acids.
4. The isolated anti-microbial peptide of claim 1 , wherein X 1 and X 2 are hydrophobic amino acids.
5. The isolated anti-microbial peptide of claim 1 , wherein X 1 and X 2 are biphenylalanine.
6. The isolated anti-microbial peptide of claim 1 , which is SEQ ID NO: 62.
7. The isolated anti-microbial peptide of claim 1 , wherein said peptide comprises at least one D-amino acid.
8. The isolated anti-microbial peptide of claim 1 , wherein said peptide comprises at least one modification selected from the group consisting of amidation and acetylation.
9. A composition comprising at least one anti-microbial peptide of claim 1 and at least one pharmaceutically acceptable carrier.
10. The composition of claim 9 , further comprising at least one antibiotic.
11. A method for inhibiting a microbial infection in a subject in need thereof, said method comprising administering to said subject the composition of claim 9 .
12. The method of claim 11 , further comprising the administration of at least one additional antibiotic.
13. The method of claim 11 , wherein said microbial infection is a staphylococcal infection.
14. The method of claim 13 , wherein said infection is a methicillin-resistant Staphylococcus aureus (MRSA) infection.