IP Library Granted Patent US 9,364,463
Granted Patent B2
US 9,364,463 · App. 14/359,213 · Granted Jun 14, 2016

Use of amino acid supplementation for improved muscle recovery

Inventors: Arny Ferrando (Little Rock, AR); Robert R. Wolfe (Little Rock, AR)
Assignee: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
A61K31/4172A23L1/3051A61K31/198A61K31/405A23V2002/00
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Quick Facts
Patent No.
US 9,364,463
App. No.
14/359,213
Granted
Jun 14, 2016
Kind
B2
Abstract

The present invention encompasses an amino acid composition for recovery of muscle strength and function.

Claims (18)

1. A method for improving recovery of muscle strength, the method comprising administering to a subject a composition comprising the following concentrations of amino acids in terms of w/w %: about 1 to 2% of histidine, about 9 to 11% of isoleucine, about 35 to 38% of leucine, about 14 to 17% of lysine, about 2 to 4% of methionine, about 5 to 7% of phenylalanine, about 8 to 9% of threonine, about 9 to 11% of valine, about 0.01 to 0.2% of tryptophan, and about 8 to 11% of arginine, wherein recovery of muscle strength of the subject is improved relative to recovery of muscle strength in a subject not administered said amino acid composition.

2. The method of claim 1 , wherein muscle strength recovery is improved during rehabilitation from a post-surgical trauma.

3. The method of claim 2 , wherein the subject is a human 40 years of age or older.

4. The method of claim 2 , wherein the post-surgical trauma is selected from the group consisting of hip surgery trauma and knee surgery trauma.

5. The method of claim 1 , wherein muscle strength and recovery is improved after physical exercise.

6. The method of claim 5 , wherein a 15 g dose of the composition is administered to a human subject one, two, or three times a day.

7. The method of claim 1 , wherein muscle strength improves about 4%/day over pre-trauma levels when measured using maximal voluntary contraction at 8 weeks post surgery.

8. The method of claim 1 , wherein the composition comprises the following concentrations of amino acids in terms of w/w %: 1.5% of histidine, 9.7% of isoleucine, 36.4% of leucine, 15.2% of lysine, 3% of methionine, 6.1% of phenylalanine, 8.5% of threonine, 10% of valine, 0.06% of tryptophan, and 9% of arginine.

9. A method for improving muscle strength, the method comprising administering to a subject a composition comprising the following concentrations of amino acids in terms of w/w %: about 1 to 2% of histidine, about 9 to 11% of isoleucine, about 35 to 38% of leucine, about 14 to 17% of lysine, about 2 to 4% of methionine, about 5 to 7% of phenylalanine, about 8 to 9% of threonine, about 9 to 11% of valine, about 0.01 to 0.2% of tryptophan, and about 8 to 11% of arginine, wherein muscle strength of the subject is improved relative to muscle strength in a subject not administered said amino acid composition.

10. The method of claim 9 , wherein muscle strength is improved during rehabilitation from a post-surgical trauma.

11. The method of claim 9 , wherein muscle strength is improved after physical exercise.

12. The method of claim 11 , wherein a 15 g dose of the composition is administered to a human subject one, two, or three times a day.

13. The method of claim 9 , wherein the composition comprises the following concentrations of amino acids in terms of w/w %: 1.5% of histidine, 9.7% of isoleucine, 36.4% of leucine, 15.2% of lysine, 3% of methionine, 6.1% of phenylalanine, 8.5% of threonine, 10% of valine, 0.06% of tryptophan, and 9% of arginine.

14. A method for maintaining muscle strength, the method comprising administering to a subject a composition comprising the following concentrations of amino acids in terms of w/w %: about 1 to 2% of histidine, about 9 to 11% of isoleucine, about 35 to 38% of leucine, about 14 to 17% of lysine, about 2 to 4% of methionine, about 5 to 7% of phenylalanine, about 8 to 9% of threonine, about 9 to 11% of valine, about 0.01 to 0.2% of tryptophan, and about 8 to 11% of arginine, wherein muscle strength of the subject is maintained relative to muscle strength in a subject not administered said amino acid composition.

15. The method of claim 14 , wherein muscle strength is maintained during rehabilitation from a post-surgical trauma.

16. The method of claim 14 , wherein muscle strength is maintained after physical exercise.

17. The method of claim 16 , wherein a 15 g dose of the composition is administered to a human subject one, two, or three times a day.

18. The method of claim 14 , wherein the composition comprises the following concentrations of amino acids in terms of w/w %: 1.5% of histidine, 9.7% of isoleucine, 36.4% of leucine, 15.2% of lysine, 3% of methionine, 6.1% of phenylalanine, 8.5% of threonine, 10% of valine, 0.06% of tryptophan, and 9% of arginine.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 4, 2018
From: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
To: BIOVENTURES, LLC
Reel/Frame 047667/0515 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 4, 2014
From: FERRANDO, ARNY; WOLFE, ROBERT R.
To: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
Reel/Frame 033029/0185 →
Continuity (3)
Provisional Application 61598586 · Feb 14, 2012
Provisional Application 61561524 · Nov 18, 2011
Related Publication 20140343112A1 · Nov 20, 2014