Pyrazine kinase inhibitors

1. A compound of Formula (I); a stereoisomer thereof, or a pharmaceutically acceptable salt thereof:

wherein

X is hydrogen or halo;

V is heteroaryl optionally substituted with one to five R 1a groups; and

each R 1a is independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, C 2-8 alkynyl, C 3-8 cycloalkylC 1-8 alkylene, C 1-8 alkoxy, C 3-8 cycloalkoxy, hydroxyC 1-8 alkylene, C 1-8 alkoxyalkylene, haloC 1-8 alkylene, haloC 1-8 alkoxy, amino, hydroxy, C 1-8 alkylamino, diC 1-8 alkylamino, C 1-8 alkylthio, oxo, halo, cyano, haloC 1-8 alkylaminocarbonyl, C 1-8 alkylaminocarbonyl, diC 1-8 alkylaminocarbonyl, aminocarbonyl, heterocyclylcarbonyl, C 1-8 alkylcarbonylamino, C 1-8 alkylsulfonyl, aminosulfonyl, C 3-8 cycloalkyl, C 1-8 alkylcarbonylpiperidinyl, heterocyclyl, phenyl, heteroaryl, heteroarylsulfinyl;

C 1-8 arylalkylene, aminoC 1-8 alkylene, aminoC 3-8 cycloalkyl, and heterocyclylC 1-8 alkylene;

R 1d is selected from the group consisting of hydrogen, C 1-8 alkyl, C 1-8 alkoxyC 1-8 alkylene, haloC 1-8 alkyl, C 1-8 alkylsulfinylC 1-8 alkylene, and C 1-8 alkylsulfonylC 1-8 alkylene, wherein R 1d is optionally substituted with one to five groups independently selected from halo, C 1-8 alkyl, amino, C 1-8 alkoxy, C 1-8 alkylthio, and hydroxy;

R 1e is hydrogen or together with R 1d and the carbon atom to which they are attached to form a C 3-8 cycloalkyl ring.

2. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein X is hydrogen.

3. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1e is hydrogen.

4. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein R 1d is selected from the group consisting of hydrogen, isopropyl, sec-butyl, tert-butyl, methyl, ethyl, CF 3 CH 2 —, CHF 2 CH 2 —, methoxymethylene, methylsulfinylethylene, and methylsulfonylethylene.

5. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein each R 1a is independently selected from the group consisting of C 1-8 alkyl and C 1-8 alkoxy.

6. A compound of claim 1 , or a pharmaceutically acceptable salt thereof, wherein V is selected from the group consisting of

each of which is optionally substituted with one to three R 1a groups independently selected from the group consisting of C 1-8 alkyl, C 3-8 cycloalkylC 1-8 alkylene, C 1-8 alkoxy, C 3-8 cycloalkoxy, hydroxyC 1-8 alkylene, C 1-8 alkoxyalkylene, haloC 1-8 alkylene, haloC 1-8 alkoxy, amino, C 1-8 alkylamino, diC 1-8 alkylamino, oxo, halo, haloC 1-8 alkylaminocarbonyl, C 1-8 alkylaminocarbonyl, diC 1-8 alkylaminocarbonyl, aminocarbonyl, heterocyclylcarbonyl, C 1-8 alkylcarbonylamino, C 1-8 alkylsulfonyl, aminosulfonyl, C 3-8 cycloalkyl, C 1-8 alkylcarbonylpiperidinyl, morpholinyl, phenyl, pyridyl, and pyrimidyl.

7. A composition comprising a compound or a pharmaceutically acceptable salt thereof, of claim 1 in combination with a pharmaceutically acceptable carrier or diluent.

8. A compound selected from the group consisting of:

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(quinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(1-methyl-1H-indol-1-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxopropan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxopropan-2-ylamino)-3-(quinolin-3-ylamino)pyrazine-2-carboxamide;

5-(1-amino-4,4,4-trifluoro-1-oxobutan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(quinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(thieno[2,3-b]pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxo-3-phenylpropan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxo-3-(thiophen-2-yl)propan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(2-amino-2-oxo-1-phenylethylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(quinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(2-amino-1-cyclopropyl-2-oxoethylamino)-3-(quinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(5-fluoropyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(quinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(thieno[2,3-b]pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(2-amino-1-cyclopropyl-2-oxoethylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(5-methylpyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(2-methylpyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(6-(trifluoromethyl)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(6-methylpyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(5-methylpyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-3-(6-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-carbamoylpyrazin-2-ylamino)-5-methylpyridine 1-oxide;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(2-methylpyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-((1-amino-4,4-difluoro-1-oxobutan-2-yl)amino)-3-((3-methylisothiazol-5-yl)amino)pyrazine-2-carboxamide;

(R)-3-((1,5-naphthyridin-3-yl)amino)-5-((1-amino-4,4,4-trifluoro-1-oxobutan-2-yl)amino)pyrazine-2-carboxamide;

(R)-3-((1,5-naphthyridin-3-yl)amino)-5-((1-amino-4,4-difluoro-1-oxobutan-2-yl)amino)pyrazine-2-carboxamide;

(R)-5-((1-amino-1-oxobutan-2-yl)amino)-3-((4-bromo-3-methylisothiazol-5-yl)amino)pyrazine-2-carboxamide;

(R)-5-((1-amino-1-oxobutan-2-yl)amino)-3-((4-iodo-3-methylisothiazol-5-yl)amino)pyrazine-2-carboxamide;

(R)-5-((1-amino-1-oxobutan-2-yl)amino)-6-iodo-3-((4-iodo-3-methylisothiazol-5-yl)amino)pyrazine-2-carboxamide;

(R)-5-((1-amino-1-oxobutan-2-yl)amino)-3-((4-chloro-3-methylisothiazol-5-yl)amino)pyrazine-2-carboxamide;

(R)-5-((1-amino-3-cyclopropyl-1-oxopropan-2-yl)amino)-6-chloro-3-((3-methylisothiazol-5-yl)amino)pyrazine-2-carboxamide;

(R)-5-((1-amino-1-oxobutan-2-yl)amino)-6-chloro-3-((3-methylisothiazol-5-yl)amino)pyrazine-2-carboxamide;

5-(1-carbamoylcyclopropylamino)-3-(6-fluoroquinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(5-methylpyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(2-methylpyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(2,6-dimethylpyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(1-methyl-1H-pyrazol-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(5-fluoropyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(isoquinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(2-amino-1-cyclopropyl-2-oxoethylamino)-3-(isoquinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3,3-dimethyl-1-oxobutan-2-ylamino)-3-(quinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3,3-dimethyl-1-oxobutan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,5-naphthyridin-3-ylamino)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,6-naphthyridin-3-ylamino)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(isoquinolin-7-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(5-(trifluoromethyl)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(6-fluoroquinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(7-fluoroquinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(8-fluoroquinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(8-fluoroquinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(8-fluoroquinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(1-methyl-1H-pyrazol-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3,3-dimethyl-1-oxobutan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxopropan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(5-chloropyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(1-(cyclopropylmethyl)-1H-pyrazol-4-ylamino)pyrazine-2-carboxamide;

5-(1-carbamoylcyclopropylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(3-ethylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(5-chloropyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(5-chloropyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(3-ethylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(3-ethylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(3-tert-butylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(3-tert-butylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-fluoroquinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(7-fluoroquinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3,3-dimethyl-1-oxobutan-2-ylamino)-3-(6-fluoroquinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3,3-dimethyl-1-oxobutan-2-ylamino)-3-(quinolin-7-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3,3-dimethyl-1-oxobutan-2-ylamino)-3-(3-ethylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,5-naphthyridin-3-ylamino)-5-(1-amino-3,3-dimethyl-1-oxobutan-2-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(3-cyclopropylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxopropan-2-ylamino)-3-(3-cyclopropylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(3-isopropylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxopropan-2-ylamino)-3-(3-isopropylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxopropan-2-ylamino)-3-(6-fluoroquinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3,3-dimethyl-1-oxobutan-2-ylamino)-3-(3-cyclopropylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4,4-dimethyl-1-oxopentan-2-ylamino)-3-(quinolin-7-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,5-naphthyridin-3-ylamino)-5-(1-amino-4,4-dimethyl-1-oxopentan-2-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4,4-dimethyl-1-oxopentan-2-ylamino)-3-(5-fluoropyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(6-(1-amino-1-oxobutan-2-ylamino)-3-carbamoylpyrazin-2-ylamino)-N,N-dimethylisothiazole-3-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(3-(hydroxymethyl)isothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4,4-dimethyl-1-oxopentan-2-ylamino)-3-(5-methoxypyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(3-(morpholinomethypisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4,4-dimethyl-1-oxopentan-2-ylamino)-3-(2-methoxypyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(3-(methoxymethyl)isothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4,4-dimethyl-1-oxopentan-2-ylamino)-3-(1-cyclopropyl-1H-pyrazol-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(1-cyclopropyl-1H-pyrazol-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4,4-dimethyl-1-oxopentan-2-ylamino)-3-(thieno[2,3-c]isothiazol-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(2-fluoropyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4,4-dimethyl-1-oxopentan-2-ylamino)-3-(2-fluoropyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4,4-dimethyl-1-oxopentan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(thieno[3,2-c]isothiazol-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(benzo[c]isothiazol-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(thieno[2,3-c]isothiazol-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(6-(azetidine-1-carbonyl)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(6-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-carbamoylpyrazin-2-ylamino)picolinic acid;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-(azetidine-1-carbonyl)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-(3,3-difluoroazetidine-1-carbonyl)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(2-methoxypyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-(dimethylamino)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-methoxy-5-methylpyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(6-methoxypyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(6-(dimethylamino)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-(dimethylamino)-5-methylpyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(2-methoxypyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-(2,2,2-trifluoroethoxy)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-methoxypyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(2-(dimethylamino)benzo[d]oxazol-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-(azetidin-1-yl)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(4-methylpyridin-2-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(5-methoxypyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(5-methoxypyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(6-methoxypyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methyl-1-oxobutan-2-ylamino)-3-(6-(2,2,2-trifluoroethoxy)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-(3-cyanoazetidine-1-carbonyl)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(6-(azetidin-1-yl)pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(2-(dimethylamino)pyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-ethylpyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(6-cyclopropylpyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(2-cyclopropylpyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(2-cyclopropylpyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(6-ethylpyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)-3-(6-cyclopropylpyridin-3-ylamino)pyrazine-2-carboxamide ;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(2-(trifluoromethyppyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(2-(dimethylamino)pyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(2-cyclobutoxypyridin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-methoxy-1-oxopropan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxo-3-(pyridin-4-yl)propan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

5-(1-carbamoylcyclopropylamino)-3-(quinolin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(isoquinolin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(isoquinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(quinoxalin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(quinolin-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide ;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide ;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(quinolin-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(quinolin-7-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(isoquino lin-8-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(isoquinolin-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(isoquinolin-7-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,8-naphthyridin-3-ylamino)-5-(1-amino-1-oxobutan-2-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,6-naphthyridin-3-ylamino)-5-(1-amino-1-oxobutan-2-ylamino)pyrazine-2-carboxamide;

5-(2-amino-2-oxoethylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,5-naphthyridin-3-ylamino)-5-(1-amino-1-oxobutan-2-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,8-naphthyridin-4-ylamino)-5-(1-amino-1-oxobutan-2-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-3-(quinolin-6-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-cyclohexyl-1-oxopropan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(1-methyl-1H-indol-5-ylamino)pyrazine-2-carboxamide ;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(1-methyl-1H-indol-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(2-amino-2-oxo-1-phenylethylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(1-methyl-1H-indol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)-3-(1-methyl-1H-indol-4-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4,4,4-trifluoro-1-oxobutan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

5-((2R)-1-amino-4-(methylsulfinyl)-1-oxobutan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-4-(methylsulfonyl)-1-oxobutan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide ;

(R)-5-(1-amino-3-methoxy-1-oxopropan-2-ylamino)-3-(3-methylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(3-phenylisothiazol-5-ylamino)pyrazine-2-carboxamide;

(R)-5-(1-amino-1-oxobutan-2-ylamino)-3-(quinazolin-6-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,5-naphthyridin-3-ylamino)-5-(1-amino-3-cyclopropyl-1-oxopropan-2-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,5-naphthyridin-3-ylamino)-5-(1-amino-4-methyl-1-oxopentan-2-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,5-naphthyridin-3-ylamino)-5-(1-amino-1-oxo-3-(thiophen-2-yl)propan-2-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,5-naphthyridin-3-ylamino)-5-(1-amino-3-methoxy-1-oxopropan-2-ylamino)pyrazine-2-carboxamide;

(R)-3-(1,5-naphthyridin-3-ylamino)-5-(2-amino-2-oxo-1-phenylethylamino)pyrazine-2-carboxamide;

(R)-5-((1-amino-1-oxobutan-2-yl)amino)-3-(pyrazolo[1,5-a]pyridin-3-ylamino)pyrazine-2-carboxamide;

(R)-5-((1-amino-1-oxobutan-2-yl)amino)-3-(imidazo[1,2-a]pyridin-6-ylamino)pyrazine-2-carboxamide;

or a pharmaceutically acceptable salt thereof.