Surface modification of implant devices
The present invention provides implant devices comprising nanoscale structures on the surface thereof and methods of manufacturing such implant devices. In some embodiments, methods of manufacturing an implant device comprise exposing a surface of the implant device to an oxidative hydrothermal environment for a duration sufficient to generate nanoscale structures on the exposed surface(s) of the implant device.
1. A method of forming nanostructures on a surface of a device, comprising:
exposing the surface of a device having an initial microstructure to an oxidative hydrothermal environment using microwave irradiation, thereby forming nanostructures on the surface of the device;
wherein the average diameter of the nanostructures is about 10 to about 100 nm;
the average height of the nanostructures is about 10 to about 200 nm; and
the mean peak to valley height of the nanostructures is about 1 to about 300 nm; and
wherein the nanostructures are formed without affecting the initial microstructure.
2. The method of claim 1 , wherein the device is an implant device.
3. The method of claim 1 , wherein the oxidative hydrothermal environment comprises an oxidizing solution.
4. The method of claim 3 , wherein the oxidizing solution comprises H 2 O 2 , H 2 O, and/or NH 4 OH.
5. The method of claim 3 , wherein the oxidizing solution is heated to a target temperature.
6. The. method of claim 5 , wherein the target temperature is in the range of about 50 to about 400° C.
7. The method of claim 5 , wherein the target temperature is about 200° C.
8. The method of claim 1 , wherein the power of the microwave irradiation is in the range of about 100 to about 1,600 W.
9. The method of claim 3 , wherein exposing the surface of the device to the oxidative hydrothermal environment comprises submerging the implant device in the oxidizing solution.
10. The method of claim 1 , wherein the surface of the device is exposed to the oxidative hydrothermal environment for about 0.1 to about 4 hours.
11. The method of claim 1 , wherein the surface of the device is substantially covered in nanostructures following exposure to the oxidative hydrothermal environment.
12. The method of claim 1 , wherein the density of the nanostructures is about 5 to about 10,000 per square micrometer.
13. The method of claim 1 , wherein the surface of the device is pretreated prior to exposure to the oxidative hydrothermal environment.
14. The method of claim 13 , wherein pretreatment of the surface of the device comprises degreasing, pickling, sand blasting, grit blasting, acid etching, machining and/or laser etching.
15. The method of claim 1 , wherein the device is a metallic device.
16. The method of claim 1 , wherein the device is a ceramic device.
17. The method of claim 1 , wherein the device comprises titanium, a titanium alloy and/or titanium dioxide.
18. The method of claim 17 , wherein the titanium alloy comprises Ti 6 Al 4 V.