Silicon-containing fumaric acid esters
View Patent ↗The present invention is directed to silicon-containing fumaric acid esters of the Formulae I-IV. The silicon-containing fumaric acid esters of Formulae I-IV are useful in transplantation medicine and for the treatment of autoimmune diseases and autoimmune-related diseases. (I), (II), (III) & (IV).
1. A compound having Formula II:
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is C 1 -C 24 alkyl or C 6 -C 10 aryl; R 1 being unsubstituted;
each of, independently, R 2 and R 3 , is C 1 -C 10 alkyl or C 6 -C 10 aryl;
R 2 and R 3 are the same or different, and are optionally substituted.
2. The compound of claim 1 , wherein each of R 2 and R 3 , independently, is methyl, ethyl, or isopropyl.
3. The compound of claim 1 , wherein R 1 is methyl, ethyl, or isopropyl.
4. A compound having Formula IV:
or a pharmaceutically acceptable salt thereof, wherein:
R 1 is C 1 -C 24 alkyl or C 6 -C 10 aryl; and
R 2 is C 1 -C 10 alkyl.
5. The compound of claim 4 , wherein R 2 is methyl, ethyl, or isopropyl.
6. The compound of claim 4 , wherein each R 1 , independently, is methyl, ethyl, or isopropyl.
7. The compound of claim 2 , wherein the compound is (E)-O,O′-(dimethylsilanediyl)dimethyl difumarate.
8. The compound of claim 4 , wherein the compound is trimethyl (methylsilanetriyl) trifumarate.