IP Library › Patent Application 14364320
Patent Application
App. No. 14/364,320

ANTAGONIST OF THE FIBROBLAST GROWTH FACTOR RECEPTOR 3 (FGFR3) FOR USE IN THE TREATMENT OR THE PREVENTION OF SKELETAL DISORDERS LINKED WITH ABNORMAL ACTIVATION OF FGFR3

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Quick Facts
Patent No.
US None
App. No.
14/364,320
Abstract

The present invention relates to the treatment or prevention of skeletal disorders, in particular skeletal diseases, developed by patients that display abnormal increased activation of the fibroblast growth factor receptor 3 (FGFR3), in particular by expression of a constitutively activated mutant or FGFR3.

Claims (5)

1 . A method for treating or preventing a FGFR3-related skeletal disease which comprises the step of administering at least one antagonist of the FGFR3 tyrosine kinase receptor of formula:

or a composition comprising such an antagonist, to a subject in need thereof.

2 . The method according to claim 1 , wherein the FGFR3-related skeletal disease is selected from the group consisting of thanatophoric dysplasia type I, thanatophoric dysplasia type II, severe achondroplasia with developmental delay and acanthosis nigricans, hypochondroplasia, achondroplasia and FGFR3-related craniosynostosis such as Muenke syndrome and Crouzon syndrome with acanthosis nigricans.

3 . The method according to claim 2 , wherein the FGFR3-related skeletal disease is achondroplasia.

4 - 20 . (canceled)

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2015
From: MUNNICH, ARNOLD; BUSCA, PATRICIA; BARBAULT, FLORENT
To: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE PARIS DESCARTES; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); ASSISTANCE PUBLIQUE-HOPITAUX DE PARIS; UNIVERSITE PARIS DIDEROT - PARIS 7; IMAGINE
Reel/Frame 035491/0545 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 29, 2014
From: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
To: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM); UNIVERSITE PARIS DESCARTES; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); ASSISTANCE PUBLIQUE HOPITAUX DE PARIS; UNIVERSITE PARIS DIDEROT - PARIS 7; IMAGINE
Reel/Frame 034593/0141 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 24, 2014
From: LEGEAI-MALLET, LAURENCE
To: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
Reel/Frame 034583/0733 →