IP Library › Granted Patent US 9,045,478

Granted Patent B2

US 9,045,478 · App. 14/364,451 · Granted Jun 2, 2015

Substituted pyrazolo[1,5-a] pyridine as tropomyosin receptor kinase (Trk) inhibitors

Inventors: Pradip Kumar Sasmal (Hyderabad, IN); Shahadat Ahmed (Bangalore, IN); Ashok Tehim (Ridgewood, NJ); Vidyadhar Paradkar (Branchburg, NJ); Prasanna M. Dattatreya (Hyderabad, IN); Nanjegowda Jagadeesh Mavinahalli (Bangalore, IN)

C07D471/04 C07D519/00

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Quick Facts

Patent No.: US 9,045,478
App. No.: 14/364,451
Granted: Jun 2, 2015
Kind: B2

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Abstract

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

Claims (374)

1. A compound of formula (I),

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, wherein

A is

X 1 is CH or N;

R 1 represents hydrogen or —(C 1 -C 6 )alkyl;

R 2 is independently selected from hydrogen, halogen, cyano, —(C 1 -C 6 )alkyl, -halo(C 1 -C 6 )alkyl, -halo(C 1 -C 6 )alkoxy, phenyl optionally substituted with 1 to 3 halogens or an optionally substituted —O-heterocyclyl wherein the optional substituent is selected from alkyl, —OR i or —C(O)N(R i ) 2 ;

when X 1 is CH, optionally two R 2 s present on any two adjacent carbon atoms combine to form a 5 to 7 membered heterocyclic ring;

R 3 is independently selected from halogen, cyano, —OR i , —C(O)N(R i ) 2 or two R 3 s together with the carbon atom they are attached form a (C 3 -C 7 )cycloalkyl group spiro attached to pyrrolidine; or two R 3 when they are attached to adjacent carbon atoms form a (C 3 -C 7 )cycloalkyl ring fused to the pyrrolidine;

R a is selected from

(i) a group selected from optionally substituted —(C 1 -C 6 )alkyl, -hydroxy(C 1 -C 6 )alkyl or —(C 1 -C 6 )alkyl-(C 1 -C 6 )alkoxy wherein the optional substituent is selected from cyano, halogen or —(C 6 -C 12 )aryl,

(ii) an optionally substituted —(C 3 -C 10 )cycloalkyl wherein the optional substituent is selected from cyano, —(C 1 -C 6 )alkyl, hydroxyl, halogen or —R s ,

(iii) an optionally substituted —(C 6 -C 12 )aryl wherein the optional substituent is selected from cyano, hydroxyl, halogen, —(C 1 -C 6 )alkyl or —R r

(iv) an optionally substituted 5 to 10 membered heterocyclyl wherein the optional substituent is selected from cyano, hydroxyl, halogen or —(C 1 -C 6 )alkyl,

(v) an optionally substituted 5 to 10 membered heteroaryl wherein the optional substituent is selected from cyano, oxo (═O), hydroxyl, halogen, —(C 1 -C 6 )alkyl, —(C 1 -C 6 )alkoxy, —NR c R d or —R r ,

(vi) —NR 4 R 5 ,

(vii) —(C 1 -C 6 )alkyl-(C 6 -C 12 ) aryl;

R b represents hydrogen or halogen;

R 4 is selected from hydrogen, —(C 1 -C 6 )alkyl, —(C 3 -C 10 )cycloalkyl, -hydroxy(C 1 -C 6 )alkyl, -alkoxy(C 1 -C 6 )alkyl, halogen (C 1 -C 6 )alkyl or —(C 1 -C 6 )alkyl-(C 3 -C 10 )cycloalkyl;

R 5 is selected from from hydrogen or —(C 1 -C 6 )alkyl or —(C 1 -C 6 )alkyl-(C 3 -C 10 )cycloalkyl;

alternatively R 4 and R 5 together with the nitrogen atom to which they are attached may form an optionally substituted 5 to 10 membered heterocyclic ring optionally containing 1-2 additional heteroatoms or groups selected from —O—, —S—, —N—, —C(═O)—, S(═O)— or —S(═O) 2 —, wherein the optional substituent is selected from hydroxyl, —(C 1 -C 6 )alkyl, —C(═O)—(C 1 -C 6 )alkyl, mesyl or COOR e ;

R c and R d are independently selected from hydrogen or —(C 1 -C 6 )alkyl;

R e is selected from hydrogen or alkyl;

R i is hydrogen, —(C 1 -C 6 )alkyl, -halo(C 1 -C 6 )alkyl, — (C 1 -C 6 )alkyl-(C 1 -C 6 )alkoxy, — (C 3 -C 10 )cycloalkyl, optionally substituted —(C 1 -C 6 )alkyl-(C 3 -C 10 )cycloalkyl wherein the optional substituent is halogen or —(C 1 -C 6 )alkyl substituted with 1 to 3 hydroxy groups;

R r is independently selected from a 5 to 10 membered heterocyclyl or a 5 to 10 membered heteroaryl, wherein optional substituent is selected from hydroxyl, halogen, —(C 1 -C 6 )alkyl or —(C 1 -C 6 )alkoxy;

R s is an optionally substituted —(C 1 -C 6 )alkyl-(C 6 -C 10 )aryl, wherein the optional substituent is halogen;

m is independently represents 0, 1, 2, 3 or 4; and

n is independently represents 0, 1, 2, or 3.

2. The compound of formula (I), wherein

A is

X 1 is CH or N.

3. The compound according to claim 2 , having the formula (Ia)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof.

4. The compound according to claim 3 , having the formula (Ib)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, wherein the values of all the variables are as described for compound of formula (Ib).

5. The compound according to claim 1 , having the formula (Ic)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof.

6. The compound according to claim 5 having the formula (Id):

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or

stereoisomers thereof.

7. The compound according to claim 3 , having the formula (Ie)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof.

8. The compound according to claim 4 , having the formula (If)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof.

9. The compound according to claim 1 , having the formula (Ig)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof.

10. The compound according to claim 9 , having the formula (Ih):

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or

stereoisomers thereof.

11. The compound according to claim 1 , having the formula (Ii)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof.

12. The compound according to claim 11 , having the formula (Ij)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof.

13. The compound according to claim 1 , having the formula (Ik)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or

stereoisomers thereof.

14. The compound according to claim 1 , having the formula (Il)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, wherein R 3 is fluorine, n is 1 or 2.

15. The compound according to claim 14 , having the formula (Im)

their pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof.

16. The compound according to claim 1 , wherein R b is hydrogen.

17. The compound according to claim 1 , wherein R b is fluorine.

18. The compound according to claim 1 , wherein R 2 is fluorine.

19. The compound according to claim 1 , wherein R 3 is fluorine.

20. The compound according to claim 4 , wherein R 2 is independently represents halogen, cyano or haloalkyl; R 4 and R 5 are independently represent methyl, ethyl or propyl and m is 1 or 2.

21. The compound according to claim 20 , wherein R a , independently represents methyl, ethyl, propyl, isopropyl, butyl or tert-butyl.

22. The compound according to claim 10 , wherein R 2 , in each occurrence, independently represents halogen, cyano or haloalkyl and m is 1 or 2.

23. The compound according to claim 22 , wherein R 4 and R 5 are independently represent methyl, ethyl or propyl.

24. A compound which is

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-methyl pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(cyclohexylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(cyclopentylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-4-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-5-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-4-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,4-dimethylthiazol-5-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((tetrahydro-2H-pyran-4-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2-methyltetrahydrofuran-3-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl) sulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-methoxypyridin-3-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-((6-(1H-1,2,4-triazol-1-yl)pyridin-3-yl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-4-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-morpholinophenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyridin-3-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-((5-chlorothiophen-2-yl) sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-((2,5-dichlorothiophen-3-yl) sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(cyclobutylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(benzo[d][1,3]dioxol-5-ylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2,2,2-trifluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Isomer-I),

N-(tert-butylsulfonyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Isomer-II),

N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Isomer-I),

N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Isomer-II),

(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(S)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-4-fluoro pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxyl)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((R)-2-(3,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-((6-(1H-1,2,4-triazol-1-yl) pyridin-3-yl) sulfonyl)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((R)-2-(3,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl) sulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N-((1-methyl cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl) pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl) pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethyl sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methyl sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N-(cyclopropylmethyl)-N-methylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N,N-diethylsulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N,N-dimethyl sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(morpholinosulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(pyrrolidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-methylpiperazin-1-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N,N-diethylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(piperidin-1-ylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methyl sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N-ethyl-N-methylsulfamoyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(((S)-3-hydroxypyrrolidin-1-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-sulfamoylpyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-I),

N—(N-ethyl-N-methylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-II),

N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-I),

N—(N,N-dimethylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-II),

N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-I),

N—(N-ethyl-N-methylsulfamoyl)-5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-II),

N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N—(N,N-dimethylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N—(N-ethyl-N-methylsulfamoyl)-5-((R)-2-(3-fluoro-5-(((R)-tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-sulfamoyl pyrazolo[1,5-a]pyridine-3-carboxamide,

N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-I),

N—(N,N-dimethylsulfamoyl)-5-(2-(8-fluoro-3,4-dihydro-2H-benzo[b][1,4]dioxepin-6-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-2);

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N—(N-isobutyl-N-methyl sulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N,N-dimethylsulfamoyl)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N-ethyl-N-methylsulfamoyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((2R)-2-(3-((2,2-difluorocyclopropyl)methoxy)-5-fluorophenyl)pyrrolidin-1-yl)-N—(N-ethyl-N-methylsulfamoyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N—(N,N-bis(cyclopropylmethyl)sulfamoyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N—(N-ethyl-N-methylsulfamoyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Diastereomer-II),

N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Racemic mixture);

(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropyl sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

Sodium (tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium (R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium (tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl) (N,N-dimethylsulfamoyl)amide,

Sodium (tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)-4,4-difluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl) sulfonyl)amide,

Sodium (tert-butylsulfonyl)(5-((2R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium (5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(N,N-dimethylsulfamoyl)amide,

Sodium (tert-butylsulfonyl)(4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium (R)—(N,N-dimethylsulfamoyl)(4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium (N-ethyl-N-methylsulfamoyl)(5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl) pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(o-tolylsulfonyl)amide,

Sodium (4-fluoro-5-((2R,4S)-4-fluoro-2-(3-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl) (isopropylsulfonyl)amide,

Sodium (5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl)sulfonyl)amide, or

Sodium (R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)(piperidin-1-ylsulfonyl)amide;

or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable solvate thereof or a stereoisomer thereof.

25. The compound according to claim 1 , which is

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-((3-cyanophenyl)sulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-((3-cyanophenyl) sulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-N-methylpyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-morpholinophenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(o-tolylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-fluorophenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((R)-2-(3,5-difluorophenyl)pyrrolidin-1-yl)-N-((4-((S)-3-hydroxypyrrolidin-1-yl)phenyl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl) (piperidin-1-ylsulfonyl)amide, or

Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl) (o-tolylsulfonyl)amide;

or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable solvate thereof or a stereoisomer thereof.

26. The compound according to claim 1 , which is

(R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(ethylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(methylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(propylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(isobutylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-(neopentylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(benzylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-methoxyphenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(3-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoropyridin-3-yl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-ethoxy-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-(cyclopropylmethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-chloro-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-((2R,4R)-2-(2,5-difluorophenyl)-4-hydroxypyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoro pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(4,4′-difluoro-[1,1′-biphenyl]-2-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-fluoroethoxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-((2R)-2-(5-fluoro-2-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)-4-fluoro pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)-4-fluoropyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-(difluoromethoxy)-5-fluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(2-fluoro-5-(2-methoxyethoxyl)phenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-(2-methoxyethoxyl)phenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(3-fluoro-5-(2-methoxyethoxyl)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-((2R)-2-(3-fluoro-5-((tetrahydrofuran-3-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl) pyrazolo[1,5-a]pyridine-3-carboxamide,

N-(tert-butylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide (Racemic mixture),

(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-methoxyphenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(3,5-difluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-4-fluoro-5-(2-(3-fluorophenyl)pyrrolidin-1-yl)-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(tert-butylsulfonyl)-4-fluoro-5-(2-(5-fluoro-2-((tetrahydro-2H-pyran-4-yl)oxy)phenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

Sodium(tert-butylsulfonyl)(5-((2R,4R)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium(tert-butylsulfonyl)(5-((2R,4S)-2-(2,5-difluorophenyl)-4-fluoropyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide,

Sodium(R)-(tert-butylsulfonyl)(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide, or

Sodium(R)-(tert-butylsulfonyl)(5-(2-(7-fluoro-2,3-dihydrobenzo[b][1,4]dioxin-5-yl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)amide;

or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable solvate thereof or a stereoisomer thereof.

27. The compound according to claim 1 , which is

(R)—N-(cyclopropylsulfonyl)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(cyclohexyl sulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(cyclopentyl sulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)—N-(cyclobutylsulfonyl)-5-(2-(2,5-difluorophenyl) pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-ethylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methylcyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-(4-fluorobenzyl)cyclopropyl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-4-fluoro-N-(isopropylsulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide, or

Sodium(R)-(5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carbonyl)((1-methylcyclopropyl) sulfonyl)amide;

or a pharmaceutically acceptable salt thereof, a pharmaceutically acceptable solvate thereof or a stereoisomer thereof.

28. The compound according to claim 1 , which is

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((3,5-dimethylisoxazol-4-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-4-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1,2-dimethyl-1H-imidazol-5-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-imidazol-4-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-1H-pyrazol-5-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((2,4-dimethylthiazol-5-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((1-methyl-2-oxoindolin-5-yl)sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-(dimethylamino) pyridin-3-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-N-((6-((S)-3-hydroxypyrrolidin-1-yl) pyridin-3-yl) sulfonyl)pyrazolo[1,5-a]pyridine-3-carboxamide,