Composition for anti-adhesion, surgical mesh composite with anti-adhesion property comprising the same and method for producing thereof
An anti-adhesion composition with a good anti-adhesion property as well as a good biocompatibility, a surgical mesh composite with anti-adhesion property comprising the same and method for producing the same are provided.
1. A surgical mesh composite, comprising a surgical mesh layer and an anti-adhesion layer and having an anti-adhesion property, wherein the anti-adhesion layer consists of a mixture of insoluble carboxymethylcellulose and polyhydric alcohol.
2. The surgical mesh composite according to claim 1 , wherein the carboxymethylcellulose is an alkali salt of carboxymethylcellulose.
3. The surgical mesh composite according to claim 1 , wherein the polyhydric alcohol is present at an amount of 100 parts by weight or less, with respect to 100 parts by weight of carboxymethylcellulose.
4. The surgical mesh composite according to claim 1 , wherein the polyhydric alcohol is glycerol.
5. The surgical mesh composite according to claim 1 , wherein the anti-adhesion layer is contained at 10 to 90 parts by weight, with respect to 100 parts by weight of the surgical mesh composite.
6. The surgical mesh composite according to claim 1 , wherein the thickness of surgical mesh composite ranges from 100 to 900 μm.
7. The surgical mesh composite according to claim 1 , which further comprises a biodegradable polymer adhesive layer located between the surgical mesh layer and the anti-adhesion layer.
8. The surgical mesh composite according to claim 7 , wherein the biodegradable polymer adhesive layer is contained at 0.1 to 60 parts by weight, with respect to 100 parts by weight of the surgical mesh composite.
9. The surgical mesh composite according to claim 8 , wherein the biodegradable polymer has a weight-average molecular weight of 10,000 to 200,000 D.
10. The surgical mesh composite according to claim 7 , wherein the biodegradable polymer is a homopolymer or a copolymer prepared from at least one monomer selected from the group consisting of glycolide, glycolic acid, lactide, lactic acid, ε-caprolactone, ρ-dioxanone, trimethylene carbonate, polyanhydride and polyhydroxyalkanoate.
11. A method of preparing a surgical mesh composite according to claim 1 , comprising providing a surgical mesh layer; preparing an anti-adhesion layer consisting of a mixture of insoluble carboxymethylcellulose and polyhydric alcohol, wherein the insoluble carboxymethylcellulose is formed by heat treatment of carboxymethylcellulose with a viscosity of 100 cps to 500 cps in 1 wt % of solution; and adhering the anti-adhesion layer on the surgical mesh layer.
12. The method according to claim 11 , wherein the adhering step is performed by placing a biodegradable polymer adhesive layer located between the surgical mesh layer and the anti-adhesion layer, and performing a heat-sealing.
13. The method according to claim 12 , wherein the heat-sealing is performed with a plate heated at a temperature of 50 to 200° C. under a pressure of 10 to 1,500 psi.
14. The method according to claim 11 , wherein the heat treatment is performed at a temperature of 100 to 160° C.
15. The method according to claim 11 , wherein the heat treatment is performed at a pressure of 2,000 mmHg or lower.
16. The method according to claim 11 , wherein the mixture of carboxymethylcellulose and polyhydric alcohol is a product obtained by freezing and drying the mixture of carboxymethylcellulose and polyhydric alcohol.