Methods for treating cardiac conditions
Described herein are compositions and methods of treating a cardiac condition using modified placental tissue or an extract of a placental tissue, capable of recruiting stem cells or promoting healing in vivo and in vitro.
1. A method for treating a cardiac condition in a patient in need thereof, comprising administering to said patient a sufficient amount of a composition comprising a modified placental tissue or an extract of a placental tissue to an area proximate to the heart of the patient, wherein the amount of said modified placental tissue or extract is sufficient to promote stem cell recruitment to said area;
wherein the modified placental tissue comprises an amnion having an epithelial cell layer and/or a fibroblast cell layer; wherein the composition is micronized.
2. The method of claim 1 , wherein said cardiac condition is an inflammatory heart condition, which method comprises placing an effective amount of said composition at or adjacent to an inflammatory cardiac tissue without obstructing the function thereof, wherein the modified placenta tissue or extract is placed under conditions that promote treatment of the inflammation in said cardiac tissue.
3. The method of claim 1 , wherein the cardiac condition is selected from the group consisting of acute myocardial infarction, myocardial infarction, cardiomyopathy, unstable angina, refractory angina, heart attack, heart failure, cor pulmonale, vein graft diseases, coronary heart diseases, occlusive coronary thrombus, valvular heart diseases, inflammatory cardiomegaly, atherosclerosis, acute pericarditis, Dressler syndrome, an inflammatory heart condition and a necrotizing heart condition.
4. The method of claim 1 , wherein the composition comprises an effective amount of stem cell recruiting factors.
5. The method of claim 1 , wherein the composition comprises an effective amount of growth factors.
6. The method of claim 1 , wherein the composition comprises an effective amount of angiogenesis inducing factors.
7. The method of claim 1 , wherein the composition comprises one or more of PDGF-AA, PDGF-BB, TGFa, TGFβ, bFGF, EGF, VEGF, IL-10, IL-4, P1GF, TIMP-2, and TIMP-4.
8. The method of claim 7 , wherein stem cells are recruited by the composition.
9. The method of claim 1 , wherein the placental tissue has a mass sufficient to recruit stem cells to an area to be treated.
10. The method of claim 1 , wherein the cardiac condition is a necrotizing heart condition.
11. The method of claim 1 , wherein the cardiac condition is selected from the group consisting of heart failure, cor pulmonale, vein graft diseases, coronary heart diseases, occlusive coronary thrombus, valvular heart diseases, inflammatory cardiomegaly, atherosclerosis, inflammation of a heart valve, inflammatory cardiomyopathy, myocarditis, endocarditis, a necrotizing condition, chronic pericarditis, acute pericarditis and Dressler syndrome.
12. The method of claim 1 , wherein the composition is in an injectable form.
13. The method of claim 1 , wherein the composition is a patch.
14. The method of claim 1 , wherein the composition is in sustained or continuous release form.
15. The method of claim 1 , wherein the composition comprises a modified placental tissue.
16. The method of claim 1 , wherein the composition comprises an extract of a placental tissue.