Water-based organic bismuth, elemental sulfur and lithium carbonate sterilization indicator composition
View Patent ↗Water-based formulations comprising an indicating composition dispersed in water are described. The water-based indicating compositions include an organic Bi(III) compound, a sulfur source, and a carbonate salt. Formulations further including a resin and/or an acidic additive are also described.
1. An indicator formulation comprising an indicating composition dispersed in water, wherein the indicating composition comprises
(a) an organic Bi(III) compound;
(b) elemental sulfur; and
(c) lithium carbonate;
wherein the organic Bi(III) compound has a solubility in water at 20° C. of less than 5 grams/100 ml.
2. The indicator formulation of claim 1 , wherein the indicating composition comprises bismuth subcarbonate formed in situ.
3. The indicator formulation of claim 1 , wherein the organic Bi(III) compound has a solubility in water at 20° C. of less than 1 gram/100 ml.
4. The indicator formulation of claim 1 wherein the organic Bi(III) is selected from the group consisting of bismuth subsalicylate, bismuth citrate, bismuth tartrate, and combinations thereof.
5. The indicator formulation of claim 1 , further comprising an acidic compound.
6. The indicator formulation of claim 5 , wherein the acidic compound is non-polymeric.
7. The indicator formulation of claim 6 , wherein the acidic compound is selected from the group consisting of citric acid, gallic acid, oxalic acid, and combinations thereof.
8. The indicator formulation of claim 1 , further comprising a resin.
9. The indicator formulation of claim 8 , wherein the resin comprises an acrylic resin.
10. An indicator tape comprising a substrate and an indicator composition on a portion of at least one surface of the substrate, wherein the indicator tape was prepared by the process of applying the indicator formulation according to any one of the preceding claims to the surface of the substrate and drying the formulation.
11. A method of preparing an indicator formulation comprising combining an organic Bi(III) compound; elemental sulfur; and lithium carbonate in water; wherein the organic Bi(III) compound has a solubility in water at 20° C. of less than 5 grams/100 ml, and reacting the organic Bi(III) compound with the lithium carbonate to form bismuth subcarbonate.