Temperature controlled support surfaces for single use flexible wall systems

1. A heat exchange module for use in a chemical, pharmaceutical or biological reactor system having a single use flexible container, the module comprising:

a body having a central chamber configured for receiving the single use flexible container and configured to be disposed in a reactor vessel, the body comprising:

an outer surface configured to conform to a shape of the reactor vessel;

at least one thermally conductive surface adapted to contact the flexible container to facilitate heat transfer; and

at least one integral baffle forming a protrusion into the central chamber such that when the flexible container is inserted into the chamber, a fluid within the flexible container is baffled by the at least one baffle,

wherein the body is an elongate body having a top end and a bottom end and is adapted to be inserted into the reactor vessel such that the body extends at least a substantial portion of the distance between a top and a bottom of the reactor vessel; and

a heat exchanger disposed at the outer surface of the body, the heat exchanger comprising a fluid circulation path through which a heat exchange fluid can be circulated around the circumference of the body and into and out of a channel in the at least one baffle, such that when the flexible container is inserted into the chamber, a fluid within the flexible container is heated or cooled by the heat exchange fluid and baffled by the at least one baffle.

2. The heat exchange module of claim 1 , wherein the fluid circulation path comprises:

an elongate tube or channel axially positioned at the outer surface of the body and extending substantially the length of the body, the elongate tube or channel configured for delivering the heat exchange fluid through the elongate tube or channel; and

a flow path of the heat exchange fluid from the opening at the bottom of the elongate tube or channel to an outlet or an outlet tube at the top end of the body.

3. The heat exchange module of claim 1 , wherein the body is configured to extend to a position opposite an impeller positioned at or near the bottom of the single use flexible container, and the at least one integral baffle configured to baffle a shear field produced by the impeller.

4. The heat exchange module of claim 1 , wherein the heat exchange module is integrally formed as a part of the reactor vessel and wherein the at least one baffle comprises the thermally conductive surface adapted to contact the single use flexible container and to facilitate heat transfer.

5. The heat exchange module of claim 4 , wherein the heat exchange module is integrally formed as part of the reactor vessel and the fluid circulation path further comprises at least one non-linear channel disposed within a wall of the reactor vessel.

6. The heat exchange module of claim 5 , wherein the non-linear channel further comprises at least one of spiral, serpentine and maze-like pathways configured to maintain the thermally conductive surface at a desired temperature.

7. The heat exchange module of claim 1 , wherein:

the at least one baffle includes a separator plate positioned within the channel in the baffle;

wherein the at least one separator plate is configured to prevent the heat exchange fluid from flowing vertically within the channel in the baffle.

8. The heat exchange module of claim 7 , wherein:

the at least one separator plate is a plurality of separator plates disposed within the channel in the baffle.