2-benzyl, 3-(pyrimidin-2-yl) substituted pyrazoles useful as sGC stimulators
View Patent ↗Compound of Table I are described. They are useful as stimulators of sGC, particularly NO-independent, heme-dependent stimulators. These compounds may be useful for treating, preventing or managing various disorders that are herein disclosed.
1. A compound depicted below, or a pharmaceutically acceptable salt thereof:
2. A pharmaceutical composition comprising at least one compound of claim 1 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.
3. A compound depicted below, or a pharmaceutically acceptable salt thereof:
4. A compound depicted below, or a pharmaceutically acceptable salt thereof:
5. A pharmaceutical composition comprising at least one compound of claim 3 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.
6. A pharmaceutical composition comprising at least one compound of claim 4 , or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient.