Piperidino-pyrimidine derivatives for the treatment of viral infections
View Patent ↗This invention relates to piperidino-pyhmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
1. A compound of formula (I)
or a pharmaceutically acceptable salt, tautomer, or solvate thereof, wherein
A is selected from the group consisting of CH 2 , NCOR 2 , CHR 3 and CR 3 R 3 in any stereo chemical configuration,
B is selected from the group consisting of CH 2 , NCOR 4 , CHR 3 and CR 3 R 3 in any stereo chemical configuration,
with the proviso that when A is NCOR 2 then B is not NCOR 4 and with the proviso that A and B are not both selected from CH 2 , CHR 3 or CR 3 R 3 ,
X is selected from CH 2 or CHR 5 in any stereo chemical configuration,
R 1 is selected from C 1-8 alkyl optionally substituted with one or more of the following: C 1-6 alkyl, C 3-7 cycloalkyl, hydroxyl, hydroxyalkyl, amino, nitrile, alkoxy and alkoxy-(C 1-4 )alkyl,
R 2 is selected from substituted and unsubstituted C 1-6 alkyl, C 3-7 cycloalkyl, heterocycle, aryl, heteroaryl, heteroarylalkyl, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, C 1-6 alkyl, di-(C 1-6 )alkylamino, C 1-6 alkylamino, C 1-6 alkoxy, C 3-6 cycloalkyl, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or nitrile,
R 3 is selected from hydrogen, substituted and unsubstituted C 1-6 alkyl, alkoxy, alkoxy-(C 1-4 )alkyl, C 3-7 cycloalkyl, C 4-7 heterocycle, aromatic, bicyclic heterocycle, arylalkyl, heteroaryl, heteroarylalkyl each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, C 1-6 alkyl, di-(C 1-6 )alkylamino, C 1-6 alkylamino, C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyl, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or nitrile,
R 4 is selected from substituted or unsubstituted alkoxy, alkoxy-(C 1-4 )alkyl, aryl or C 3-7 cycloalkyl each of which is optionally substituted by heterocycle, nitrile, heteroarylalkyl or heteroaryl and wherein
R 5 is selected from aromatic, bicyclic heterocycle, aryl, heteroaryl, each of which is optionally substituted by one or more substituents independently selected from halogen, hydroxyl, amino, C 1-6 alkyl, di-(C 1-6 )alkylamino, C 1-6 alkylamino, C 1-6 alkyl, C 1-6 alkoxy, C 3-6 cycloalkyl, heterocycle, aryl, alkenyl, alkynyl, arylalkyl, heteroaryl, heteroarylalkyl or nitrile.
2. A compound of formula (I) as claimed in claim 1 wherein R 1 is butyl.
3. A compound of formula (I) as claimed in claim 1 wherein R 1 is C 4-8 alkyl substituted with hydroxyl.
4. A compound of formula (I) as claimed in claim 3 wherein R 1 selected from the group consisting of:
5. A compound of formula (I) as claimed in claim 1 wherein X is CH 2 .
6. A compound of formula (I) as claimed in claim 1 wherein X is CH 2 and A is CH 2 .
7. A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt, tautomer or solvate thereof as claimed in claim 1 together with one or more pharmaceutically acceptable excipients, diluents or carriers.