Photonic probe apparatus with integrated tissue marking facility

1. A photonic probe apparatus for marking biological tissue and comprising:

a probe for transmitting light to tissue and collecting light from an illuminated tissue region in contact with the probe;

a light source operably connected to the probe for illuminating tissue;

a light sensor operably connected to the probe to receive and detect light collected from the tissue region in contact with the probe;

an analyzing unit for determining a measure of probability of a cancerous or precancerous lesion in the tissue in contact with the probe and whether a threshold for the measure of probability of a cancerous or precancerous lesion in the tissue region in contact with the probe is exceeded based on an output signal from the light sensor; and

an integrated tissue marking facility which can be activated to mark the tissue region in contact with the probe when the threshold measure is exceeded, wherein:

the tissue marking facility comprises an electric current source connected to supply an output electrode situated in the probe with sufficient current to coagulate tissue in contact with the probe, and the probe comprises a replaceable probe tip wherein the light source, light sensor, and tissue marking facility works through the replaceable tip of the probe.

2. The photonic probe apparatus according to claim 1 , wherein the analyzing unit comprises:

an electronic processor connected to receive the output signal from the light sensor; and

a memory holding a computer program configured to, when executed by the electronic processor:

determine one or more measures of probability of a cancerous or precancerous lesion in the tissue region based on the output signal from the light sensor; and

determine whether one or more of the determined measures of probability exceeds a predetermined threshold.

3. The photonic probe apparatus according to claim 1 , wherein determining a measure of probability of cancerous or precancerous lesions involves distinguishing precancerous and/or cancerous tissue from not precancerous tissue based on the output signal from the light sensor.

4. The photonic probe apparatus according to claim 2 , wherein the electronic processor is connected to control the tissue marking facility, and wherein the computer program is configured to automatically activate the tissue marking facility to mark tissue when the threshold measure is exceeded.

5. The photonic probe apparatus according to claim 2 , further comprising an audio and/or visual output connected to the electronic processor, and wherein the computer program is configured to control the audio and/or visual output to indicate to a user whether the threshold measure is exceeded.

6. The photonic probe apparatus according to claim 1 , wherein the probe further comprises an interface allowing a user to activate the integrated tissue marking facility to mark tissue.

7. The photonic probe apparatus according to claim 1 , wherein the light sensor is configured to detect an intensity of collected light at different wavelengths to record a spectrum and wherein the threshold measure is related to the size of one or more peaks in the recorded spectrum.

8. The photonic probe apparatus according to claim 1 , further comprising a scanning mechanism for moving at least part of the probe relative to tissue of a patient.

9. A replaceable tip of a probe for a photonic probe apparatus having an integrated tissue marking facility for marking biological/in vivo tissue, the tip comprises:

one or more light transmitting parts;

an output for a tissue marking facility for marking a tissue region in contact with the replaceable tip; and

the one or more light transmitting parts aligning with a light output from and a light input to the probe, wherein:

the output for the tissue marking facility comprises an electrode connected to an electric current source of the tissue marking facility, the output electrode being arranged to be in contact with the tissue region in contact with the replaceable tip when attached to the probe.

10. A method for marking a tissue region in a patient for excision, the method comprising:

providing a probe for illuminating tissue and collecting light from an illuminated tissue region through the probe and a tissue marking facility having an output comprising an output electrode integrated in the probe;

contacting tissue in the patient with the probe;

emitting light from the probe to illuminate tissue;

sensing and analyzing light collected from a tissue region in contact with the probe to determine a measure of probability of a cancerous or precancerous lesion in the tissue region in contact with the probe and whether a threshold measure of probability of a cancerous or precancerous lesion in the tissue region in contact with the probe is exceeded; and

activating the tissue marking facility to mark the tissue region through the probe if the threshold measure is exceeded;

wherein the tissue marking facility comprises an electric current source connected to supply the output electrode with sufficient current to coagulate tissue in contact with the probe;

the probe comprises a replaceable probe tip wherein the light source, light sensor, and tissue marking facility works through the replaceable tip of the probe; and

the marking step is a separate step from the sensing and analyzing steps and is performed after the sensing and analyzing steps.