Process for the preparation of substituted phenylpropanones
View Patent ↗The invention relates to a process for the preparation of a compound of formula (I) wherein the substituents are defined as in claim 1 , which process comprises adding a compound of formula (II), wherein R 1 , R 2 and R 3 have the meanings as described under formula (I), in the presence of an inert organic solvent, to a mixture comprising an organic nitrite of formula (III) R4-O—N═O, wherein R 4 is C 1 -C 8 alkyl, a compound of formula (IV), and an inert organic solvent.
1. A process for the preparation of the compound of formula I
wherein
R 1 R 2 and R 3 are halogen
which process comprises
adding a compound of formula II
wherein R 1 , R 2 and R 3 have the meanings as described under formula I, in the presence of an inert organic solvent to a mixture comprising an organic nitrite of formula III
R 4 —O—N═O (III),
wherein R 4 is C 1 -C 8 alkyl, a compound of formula IV
and an inert organic solvent.
2. A process according to claim 1 for the preparation of a compound of formula I, wherein R 1 , R 2 and R 3 are chloro.
3. A process according to claim 1 for the preparation of a compound of formula I, wherein R 4 is C 4 -C 7 alkyl.