System for planning radiation treatment therapy

1. A method of operating a radiation delivery system according to a radiation delivery plan, wherein the radiation delivery system comprises a movable radiation source for directing and providing radiation to a designated target region within a patient, the method comprising:

implanting an optical sensor device into the patient, within or in close proximity to at least one risk region within the patient, wherein a risk region comprises tissue not targeted by the radiation delivery plan, the optical sensor device comprising at least one orientation fiber core configured to measure an orientation of the optical sensor device relative to a point of reference, and at least one radiation fiber core configured to measure a dose of radiation received by the optical sensor device;

optically interrogating the at least one orientation fiber core to generate orientation information regarding the optical sensor device during a radiation delivery to the patient, and using the orientation information to estimate a risk region orientation during the radiation delivery;

optically interrogating the at least one radiation fiber core to generate radiation dosage information regarding the optical sensor device during the radiation delivery, and using the radiation dosage information to estimate a risk region radiation dosage during the radiation delivery; and

determining whether to modify the radiation delivery plan based on at least one of the estimated risk region orientation and the estimated risk region radiation dosage during the radiation delivery.

2. The method of claim 1 , further comprising modifying an initial radiation delivery plan to form an updated radiation delivery plan based on at least one of the estimated risk region orientation and the estimated risk region radiation dosage.

3. The method of claim 1 , wherein the patient is being treated for prostate cancer, the at least one risk region comprises rectal tissue, and the optical sensor device comprises a rectal balloon which is implanted within the patient's rectum during the radiation delivery.

4. A radiation therapy planning system for use in generating a radiation delivery plan to be implemented by a radiation delivery system comprising a movable radiation source for directing and providing radiation to a designated target region within a patient, the planning system comprising:

an optical sensor device for being implanted within or in close proximity to at least one risk region within the patient, wherein a risk region comprises tissue not targeted by the radiation delivery plan, and comprising at least one orientation fiber core configured to measure an orientation of the optical sensor device relative to a point of reference, and at least one radiation fiber core configured to measure a dose of radiation received by the optical sensor device;

an optical interrogation console for optically interrogating the at least one orientation fiber core to generate orientation information regarding the optical sensor device during a radiation delivery to the patient, and optically interrogating the at least one radiation fiber core to generate radiation dosage information regarding the optical sensor device during the radiation delivery;

an orientation reconstructor to estimate a risk region orientation based on the orientation information during the radiation delivery;

a radiation dosage calculator to estimate a risk region radiation dosage based on the radiation information during the radiation delivery; and

a processor for determining whether to modify the radiation delivery plan based on at least one of the estimated risk region orientation and the estimated risk region radiation dosage during the radiation delivery.

5. The system of claim 4 , wherein the optical interrogation console comprises a single reflectometer to optically interrogate the at least one orientation fiber core and to optically interrogate the at least one radiation fiber core.

6. The system of claim 4 , wherein the optical sensor device comprises a substrate supporting the at least one orientation fiber core and the at least one radiation fiber core.

7. The system of claim 6 , wherein the substrate comprises a balloon.

8. The system of claim 6 , wherein the optical sensor device comprises a configurable volume.

9. The system of claim 4 , wherein the radiation fiber core comprises at least one cladding for converting incoming radiation into visible light.

10. The system of claim 4 , wherein the optical sensor device comprises an intraluminal flexible body having a cross-section being comparatively small relative to a length of the device, and the orientation fiber core is configured to collect information regarding an orientation of the intraluminal structure.

11. The system of claim 4 , wherein the processor is configured to modify an initial radiation delivery plan to form an updated radiation delivery plan based on at least one of the estimated risk region orientation and the estimated risk region radiation dosage.

12. The system of claim 4 , wherein the optical sensor device further comprises a rectal balloon for insertion into the patient's rectum during the radiation delivery.

13. The system of claim 4 , wherein the orientation reconstructor uses the orientation information to generate local strain data for a plurality of positions along the at least one orientation fiber core, and to generate local curvature and torsion angle data as a function of each local strain along the orientation fiber core, and to reconstruct the three-dimensional shape of the orientation fiber core as a function of each local curvature and torsion angle.

14. An optical sensing system comprising:

an optical sensor device for being implanted within or in close proximity to at least one risk region within a patient, wherein a risk region comprises tissue not targeted by a radiation delivery plan, and comprising at least one orientation fiber core configured to measure an orientation of the optical sensor device relative to a point of reference, and at least one radiation fiber core configured to measure a dose of radiation received by the optical sensor device;

an optical interrogation console for optically interrogating the at least one orientation fiber core to generate orientation information regarding the optical sensor device during a radiation delivery to the patient, and optically interrogating the at least one radiation fiber core to generate radiation dosage information regarding the optical sensor device during the radiation delivery;

an orientation reconstructor to estimate a risk region orientation based on the orientation information during the radiation delivery;

a radiation dosage calculator to estimate a risk region radiation dosage based on the radiation information during the radiation delivery; and

a processor for monitoring the estimated risk region orientation and the estimated risk region radiation dosage during the radiation delivery.

15. The method of claim 1 , wherein determining whether to modify the radiation delivery plan comprises comparing the estimated risk region radiation dosage to a predetermined maximum value.

16. The method of claim 1 , further comprising modifying the radiation delivery based on at least one of the estimated risk region orientation and the estimated risk region radiation dosage during the radiation delivery.

17. The method of claim 1 , further comprising stopping the radiation delivery based on at least one of the estimated risk region orientation and the estimated risk region radiation dosage during the radiation delivery.

18. The method of claim 1 , further comprising:

implanting a second optical sensor device into the patient, within or in close proximity to at least one target region within the patient, wherein the target region comprises tissue targeted by the radiation delivery plan, the second optical sensor device comprising at least one orientation fiber core configured to measure an orientation of the second optical sensor device relative to a point of reference, and at least one radiation fiber core configured to measure a dose of radiation received by the second optical sensor device;

optically interrogating the at least one orientation fiber core to generate orientation information regarding the second optical sensor device during the radiation delivery to the patient, and using the orientation information to estimate a target region orientation during the radiation delivery;

optically interrogating the at least one radiation fiber core to generate radiation dosage information regarding the second optical sensor device during the radiation delivery, and using the radiation dosage information to estimate a target region radiation dosage during the radiation delivery; and

determining whether to modify the radiation delivery plan further based on at least one of the estimated target region orientation during the radiation delivery and the estimated target region radiation dosage during the radiation delivery.

19. The method of claim 18 , further comprising modifying the radiation delivery plan based on the estimated risk region radiation dosage during the radiation delivery and the estimated target region radiation dosage during the radiation delivery.

20. The system of claim 4 , further comprising:

a second optical sensor device for being implanted within or in close proximity to at least one target region within the patient, wherein the target region comprises tissue targeted by the radiation delivery plan, and comprising at least one orientation fiber core configured to measure an orientation of the second optical sensor device relative to a point of reference, and at least one radiation fiber core configured to measure a dose of radiation received by the second optical sensor device;

wherein the system optically interrogates the at least one orientation fiber core to generate orientation information regarding the second optical sensor device during the radiation delivery to the patient and optically interrogates the at least one radiation fiber core to generate radiation dosage information regarding the second optical sensor device during the radiation delivery, to estimate a target region orientation during the radiation delivery and estimate a target region radiation dosage during the radiation delivery; and

wherein the processor determines whether to modify the radiation delivery plan further based on at least one of the estimated target region orientation during the radiation delivery and the estimated target region radiation dosage during the radiation delivery.

21. The system of claim 4 , wherein a single fiber comprises the at least one orientation fiber core and the at least one radiation fiber core.

22. The system of claim 12 , wherein the rectal balloon comprises a radiation absorbing liquid to reduce radiation delivered to the risk region.

23. The system of claim 21 , wherein the risk region is a rectal wall.