Cosmetic composition comprising a synergistic TRF2 protein activation system consisting of a combination of a peptidic soybean and yeast extract and the uses thereof
View Patent ↗A cosmetic composition having a synergistic TRF2 protein activation system consisting essentially of a combination of a peptidic soybean and yeast extract in a physiologically acceptable medium is disclosed and protecting or treating damage to the DNA of skin cells associated with aging by applying the cosmetic composition thereto, typically topically. The peptidic soybean and yeast extract is obtained by hydrolyzing at least 80% of soybeans by weight of the total weight of raw materials and at most 20% of yeast by weight of the total weight of raw materials.
1. A cosmetic composition comprising a physiologically acceptable medium, and a synergistic TRF2 protein activation system consisting essentially of a combination of a peptidic soybean and yeast extract obtained by hydrolyzing at least 80 % of soybean by weight of the total weight of raw materials and at most 20 % of yeast by weight of the total weight of raw materials and, after purification having a dry weight of about 18 to about 20 g/kg with a peptidic compound content of about 16 to about 18 g/L by weight of dry extract and a sugar content of about 0.3 to 0.5 g/L by weight of dry extract; wherein, the peptidic soybean and yeast extract is diluted to contain between 0.5 and 5.5 g/L of peptidic compounds by weight of dry extract; and
wherein the synergistic TRF2 protein activation system comprises 1% of the total weight of the cosmetic composition.
2. The composition according to claim 1 , wherein the peptidic soybean and yeast extract is obtained by hydrolyzing 90 % of soybean by weight of the total weight of raw materials and 10 % of yeast by weight of the total weight of raw materials.
3. The composition according to claim 1 , wherein the peptidic soybean and yeast extract is obtained by hydrolyzing soybeans of the class Glycine Max L . and biomass of yeasts of the Saccharomyces genus.
4. The composition according to claim 1 , wherein the peptidic soybean and yeast extract is obtained by hydrolyzing soybean and yeasts concomitantly.
5. The composition according to claim 1 , wherein the peptidic soybean and yeast extract comprises peptidic compounds consisting essentially of peptidic compounds with a molecular weight of less than 5 kDa.
6. The composition according to claim 1 , wherein the composition is in a form suitable for topical application selected from the group consisting of a cream, oil-in-water emulsion, water-in-oil emulsion, multiple emulsion, solution, suspension, microemulsion, aqueous gel, anhydrous gel, serum, vesicular dispersion, patch, spray, unguent, ointment, lotion, colloid, milk, stick and powder.
7. A method for cosmetic treatment for protecting from and/or repairing damage to the DNA of skin cells associated with aging by increasing the quantity of TRF2 in the cells without modifying the quantity and/or activity of telomerase, the method comprising: providing a cosmetic composition comprising a physiologically acceptable medium, and a synergistic TRF2 protein activation system consisting essentially of a combination of a peptidic soybean and yeast extract obtained by hydrolyzing at least 80% of soybean by weight of the total weight of raw materials and at most 20% of yeast by weight of the total weight of raw materials, after purification having a dry weight of about 18 to about 20 g/kg with a peptidic compound content of about 16 to about 18 g/L by weight of dry extract and a sugar content of about 0.3 to 0.5 g/L by weight of dry extract, wherein, the peptidic soybean and yeast extract is diluted to contain between 0.5 and 5.5 g/L of peptidic compounds by weight of dry extract; wherein the synergistic TRF2protein activation system comprises 1% of the total weight of the cosmetic composition; and topically applying the composition to a portion of the skin of the face or body to be treated.
8. The method of claim 7 , wherein the composition protects from and/or repairs double-strand breaks on the DNA of skin cells.
9. The method of claim 7 , wherein the composition protects from and/or treats the skin signs of aging.
10. The method of claim 7 , wherein the composition protects from and/or treats the skin signs of photo-aging induced by ultraviolet (UV) radiation.
11. The method of claim 9 , wherein the skin signs of aging comprise one or more of wrinkles, deep wrinkles, lines, cracks, slackening of the cutaneous and subcutaneous tissue, loss of skin elasticity and atony, loss of firmness and tone, and dermal atrophy.
12. The method of claim 7 , wherein the composition is applied in the morning as an anti-aging day care and/or at bedtime as a repairing night care.
13. The method of claim 7 , wherein the composition is applied before sun exposure, as a pre-sun care and/or after sun exposure, as an after-sun care.