Dosing regimens for echinocandin class compounds

1. A pharmaceutical composition, comprising an effective amount of compound 22 having the formula

or pharmaceutically acceptable salt thereof, in a lyophilized composition which loses less than 5% potency when stored for three months and wherein stabilizers are not present.

2. A pharmaceutical composition, comprising an effective amount of compound 22 having the formula

or pharmaceutically acceptable salt thereof, in an aqueous solution which loses less than 5% potency when stored for four months and wherein stabilizers are not present.

3. A method of treating a fungal infection comprising reconstituting a lyophilized composition to form an aqueous solution, the lyophilized composition comprising compound 22 having the formula

or pharmaceutically acceptable salt thereof, and formulated for immediate release of compound 22 or a pharmaceutically acceptable salt thereof; and

intravenously administering the aqueous solution to the subject, the aqueous solution having an effective amount of compound 22 or pharmaceutically acceptable salt thereof,

at an interval of one dose every 5 to 8 days, wherein the lyophilized composition loses less than 5% potency when stored for three months and wherein stabilizers are not present in the lyophilized composition.

4. The method of treating a fungal infection of claim 3 , wherein the interval is one dose every one week.

5. The method of claim 3 , comprising intravenously administering for at least two intervals over a period of at least two weeks.

6. The method of claim 3 , comprising intravenously administering by infusion.

7. The method of claim 3 , comprising intravenously administering by bolus injection.

8. The method of claim 3 , comprising intravenously administering 25 ml to 500 ml of the aqueous solution by infusion.

9. The method of claim 3 , wherein the subject is infected with a pathogenic fungus.

10. The method of claim 3 , wherein the lyophilized composition comprises an acetate salt of compound 22.

11. The method of claim 3 , wherein the lyophilized composition further comprises a bulking agent.

12. The method of claim 11 , wherein the bulking agent is mannitol.

13. The method of claim 11 , further comprising a buffer.

14. The method of claim 3 , further comprising a buffer.

15. The pharmaceutical composition of claim 1 , wherein the lyophilized composition further comprises a bulking agent.

16. The pharmaceutical composition of claim 15 , wherein the bulking agent is mannitol.

17. The pharmaceutical composition of claim 15 , further comprising a buffer.

18. The pharmaceutical composition of claim 1 , further comprising a buffer.