Modified polynucleotides for the production of cosmetic proteins and peptides
View Patent ↗The invention relates to cosmetic mRNAs encoding elastin, and methods of using such mRNAs.
1. A cosmetic mRNA encoding SEQ ID NO: 1245, wherein said mRNA comprises a coding region, said coding region having at least 80% identity to SEQ ID NO: 1973.
2. The cosmetic mRNA of claim 1 , wherein the cosmetic mRNA comprises a poly-A tail.
3. The cosmetic mRNA of claim 1 , wherein the cosmetic mRNA comprises at least one 5′ terminal cap.
4. The cosmetic mRNA of claim 1 where the cosmetic mRNA is substantially purified.
5. The cosmetic mRNA of claim 1 , wherein the coding region is codon optimized.
6. The cosmetic mRNA of claim 1 , wherein the cosmetic mRNA comprises a 5′ untranslated region (UTR) at the 5′ terminus of the coding region and a 3′ UTR at the 3′ terminus of the coding region.
7. The cosmetic mRNA of claim 6 , wherein the 5′UTR and the 3′UTR are not derived from the same species.
8. The cosmetic mRNA of claim 6 , wherein at least one of the 5′UTR or the 3′UTR is not derived from beta-globin.
9. The cosmetic mRNA of claim 1 , wherein the coding region is selected from the group consisting of SEQ ID NO: 1973, 1974, 1987, 1976, 1975, 1986, 1978, 1981, 1977, 1985, 3423, 3437, 3428, 3436, 3424, 3431, 3425, 3427, and 4148.