Radiopharmaceutical synthesis methods
The invention relates to products and methods that provide increased yields of certain radiopharmaceuticals.
1. A method comprising
passing a composition comprising an 18 F-bearing radiopharmaceutical through a hydrophilic regenerated cellulose filter to achieve a filtered composition, wherein recovery of the 18 F-bearing radiopharmaceutical after passage through the filter is greater than about 90%, wherein the 18 F-bearing radiopharmaceutical is:
2. The method of claim 1 , wherein the composition comprises ascorbic acid.
3. The method of claim 2 , wherein the concentration of ascorbic acid is about 50 mg/mL.
4. The method of claim 1 , wherein the composition has a pH of about 5.8.
5. The method of claim 1 , wherein the composition further comprises about 50 mg/mL ascorbic acid and has a pH of about 5.8.
6. The method of claim 1 , wherein recovery of the 18 F-bearing radiopharmaceutical after passage through the filter is greater than 95%.
7. A method comprising
passing a composition comprising an 18 F-bearing radiopharmaceutical through a hydrophilic regenerated cellulose filter to achieve a filtered composition, wherein retention of the 18 F-bearing radiopharmaceutical after passage through the filter is less than 5% wherein the 18 F-bearing radiopharmaceutical is:
8. The method of claim 7 , wherein the composition comprises ascorbic acid.
9. The method of claim 8 , wherein the concentration of ascorbic acid is about 50 mg/mL.
10. The method of claim 7 , wherein the composition has a pH of about 5.8.
11. The method of claim 7 , wherein the composition further comprises about 50 mg/mL ascorbic acid and has a pH of about 5.8.
12. The method of claim 7 , wherein retention of the 18 F-bearing radiopharmaceutical after passage through the filter is less than 4%.
13. The method of claim 7 , wherein retention of the 18 F-bearing radiopharmaceutical after passage through the filter is less than 3%.
14. The method of claim 1 , wherein the composition comprising the 18 F-bearing radiopharmaceutical is a composition of the 18 F-bearing radiopharmaceutical in an aqueous solution comprising 3-5 wt % ethanol.
15. The method of claim 7 , wherein the composition comprising the 18 F-bearing radiopharmaceutical is a composition of the 18 F-bearing radiopharmaceutical in an aqueous solution comprising 3-5 wt % ethanol.