Biophotonic compositions, kits and methods
The present disclosure provides biophotonic topical compositions, kits and their uses. In particular, the biophotonic compositions of the present disclosure are substantially resistant to leaching such that very low amounts of chromophore(s) present in the biophotonic composition leach out of the composition. The biophotonic compositions and their uses are useful for promoting wound healing and skin rejuvenation, as well as treating acne and various skin disorders.
1. A biophotonic composition comprising:
a first chromophore; wherein the first chromophore is a xanthene dye having an absorption wavelength of between about 200 nm and about 500 nm; and
a carbomer present in the biophotonic composition in an amount of between about 1.0% and about 2.0% by weight of the final composition, such that the biophotonic composition has a viscosity ranging from about 15,000 cP and about 50,000 cP, and to render the biophotonic composition substantially resistant to leaching such that less than 15% by weight of the total chromophore amount leaches out of the biophotonic composition;
wherein the first chromophore is dispersed throughout the biophotonic composition;
wherein the biophotonic composition does not comprise an oxidant; and
wherein the biophotonic composition is photoactivatable after a period of illumination of between about 1 second and about 30 seconds with an actinic light delivering a power density of less than about 150 mW/cm 2 when located at 5 cm from the biophotonic composition; and when photoactivated, the biophotonic composition emits light having a wavelength ranging from about 490 nm to about 800 nm.
2. The biophotonic composition of claim 1 , wherein the substantial resistance to leaching comprises less than 15% by weight of the total chromophore amount leaching out of the biophotonic composition into a phosphate saline buffer solution contained in a receptor compartment, through a 2.4-3 cm diameter polycarbonate (PC) membrane with a thickness of 10 microns and a pore size of 3 microns, having a top side onto which a 2 mm thick layer of the biophotonic composition is placed for 5 minutes at room temperature and pressure, and a bottom side which is in direct contact with the phosphate saline buffer solution.
3. The biophotonic composition of claim 1 , wherein the biophotonic composition is translucent.
4. The biophotonic composition of claim 3 , wherein the translucency comprises at least 20%, 30%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 85%, 90%, 95% or 100% transmittance of light through a 2 mm thick composition.
5. The biophotonic composition of claim 1 , further comprising a humectant.
6. The biophotonic composition of claim 5 , wherein the humectant is glycerine.
7. The biophotonic composition of claim 1 , wherein the first chromophore is selected from the group consisting of Eosin Y, Eosin B, Fluorescein, Rose Bengal and Phloxin B.
8. The biophotonic composition of claim 1 , wherein the first chromophore is present in an amount of about 0.001% to about 40% by weight of the total composition.
9. The biophotonic composition of claim 1 , wherein the biophotonic composition further comprises a second chromophore.
10. The biophotonic composition of claim 9 , wherein the first chromophore has an emission spectrum that overlaps at least 20% with an absorption spectrum of the second chromophore.
11. The biophotonic composition of claim 9 , wherein the first chromophore is Eosin Y, and the second chromophore is Fluorescein, and/or Phloxine B.
12. The biophotonic composition of claim 9 , wherein the first chromophore is Fluorescein, and the second chromophore is Eosin Y.
13. The biophotonic composition of claim 1 , wherein the light emitted by the biophotonic composition has a power density of between 0.005 to about 10 mW/cm 2 .
14. A method for providing cosmetic treatment, comprising:
applying topically the biophotonic composition according to claim 1 to a skin; and
illuminating said biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.
15. A method for biophotonic treatment of a skin disorder, comprising:
applying topically the biophotonic composition according to claim 1 , to a target skin tissue afflicted with the skin disorder; and
illuminating said biophotonic biophotonic composition with light having a wavelength that overlaps with an absorption spectrum of the first chromophore.
16. The method of claim 15 , wherein the skin disorder is acne.
17. The method of claim 15 , wherein the biophotonic composition is illuminated for about 1 minute to about 30 minutes.
18. The method of claim 15 , wherein the biophotonic composition is illuminated with visible non-coherent light.