IP Library Granted Patent US 10,575,737
Granted Patent B2
US 10,575,737 · App. 14/397,290 · Granted Mar 3, 2020

Optical coherent imaging medical device

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Quick Facts
Patent No.
US 10,575,737
App. No.
14/397,290
Granted
Mar 3, 2020
Kind
B2
Abstract

An OCI medical device includes a coherent light source, a light sensor, a first processing unit adapted to calculate OCI Data from the light sensor, a control unit which allows taking or loading of at least one Reference OCI Value, a second processing unit adapted to calculate the Intra-Individual Relative Assessment of the OCI Data of an Imaging Zone and the at least one OCI Reference Value, and display means adapted to show at least one Relative OCI Value. Uses and a method for assessing the blood flow of a body region use OCI imaging and include an Intra-Individual Relative Assessment between OCI Data of the Imaging Zone and at least one Reference OCI Value.

Claims (44)

1. An optical coherent imaging (OCI) medical device for imaging the tissue of a subject comprising:

a coherent light source configured to illuminate an imaging zone of the subject;

a light sensor with a two-dimensional array of pixels configured to capture an image from the imaging zone;

a first processing unit configured to process data received from the light sensor and calculate Absolute OCI Data corresponding to blood flow in the imaging zone;

a control unit which allows taking or loading of at least one Reference OCI Value associated with blood flow in a body part spaced from the imaging zone;

a second processing unit adapted to calculate Relative OCI Data, said Relative OCI Data being proportional to perfusion, velocity and/or concentration of the blood flow in the imaging zone, said Relative OCI data being calculated based on the calculated Absolute OCI Data from the imaging zone modified by the at least one Reference OCI Value and wherein the calculation is based on one of (a) a division of the Absolute OCI Data with the at least one Reference OCI value and (b) a difference between the at least one Reference OCI value and the Absolute OCI data; and

a display adapted to show the calculated Relative OCI Data.

2. The device according to claim 1 , wherein said two processing units are forming a single processing unit.

3. The device according to claim 1 , which is adapted for performing Laser Doppler Imaging (LDI).

4. The device according to claim 1 , which is adapted for performing a Laser Speckle Contrast Analysis (LASCA) or Laser Speckle Imaging (LSI).

5. The device according to claim 1 , further comprising a Body Mapping Factor Database including body mapping factor values for a population group, wherein each of the body mapping factor values represents a relationship of OCI values between two body areas for the population group.

6. The device according to claim 5 where the body mapping factor values are calculated based on the ratio of the OCI Values between two body areas.

7. A method for assessing the blood flow of a body region using optical coherent imaging (OCI) comprising;

illuminating an imaging zone in the body region with coherent light from a coherent light source;

capturing an image from the imaging zone with a light sensor having a two-dimensional array of pixels;

calculating in a processor Absolute OCI Data from the captured image data corresponding to blood flow;

capturing or loading at least one Reference OCI Value associated with blood flow in a body part spaced from the imaging zone;

calculating in the processor Relative OCI Data, said Relative OCI data being proportional to perfusion, velocity and/or concentration of the blood flow in the imaging zone, said Relative OCI data being calculated based on the calculated Absolute OCI Data from the imaging zone modified by the at least one Reference OCI Value and wherein the calculation is based on one of (a) a division of the Absolute OCI Data with the at least one Reference OCI value and (b) a difference between the at least one Reference OCI value and the Absolute OCI data; and

displaying the Relative OCI Data on a display.

8. The method according to claim 7 , further comprising using a Body Mapping Factor Database including body mapping factor values for a population group, wherein each of the body mapping factor values represents a relationship of OCI values between two body areas for the population group.

9. The method according to claims 7 , wherein the at least one Reference OCI Value is obtained or filtered such that pulsations of the heart beat are removed.

10. The device according to claim 1 , wherein the device is used to assess burn wounds or flap viability.

11. The device according to claim 1 , wherein the device is used to assess systemic vascular issues.

12. The device according to claim 1 wherein the device is used to assess ulcers or bedsores.

13. The device according to claim 5 , wherein the control unit is configured to select the body mapping factor value based on the locations of the imaging zone and the body part spaced from the imaging zone and modify the Relative OCI Data with the selected body mapping factor value.

14. The device according to claim 1 wherein the calculation of a Relative OCI Value is performed for each pixel in the Absolute OCI Data.

15. The method according to claim 8 further comprising:

selecting the body mapping factor value representing the relationship of the OCI values between two body areas for the population group based on the locations of the imaging zone and the body part spaced from the imaging zone and modifying the Relative OCI Data with the selected body mapping factor value.

16. An optical coherent imaging (OCI) medical device for imaging the tissue of a subject comprising:

a coherent light source configured to illuminate an imaging zone of the subject;

a light sensor with a two-dimensional array of pixels configured to capture an image from the imaging zone;

a first processing unit configured to process data received from the light sensor and calculate Absolute OCI Data corresponding to blood flow in the imaging zone;

a control unit which allows taking or loading of at least one Reference OCI Value associated with blood flow in a body part spaced from the imaging zone;

a second processing unit adapted to calculate Relative OCI Data, said Relative OCI Data being proportional to perfusion, velocity and/or concentration of the blood flow in the imaging zone, said Relative OCI data being calculated based on the calculated Absolute OCI Data from the imaging zone modified by the at least one Reference OCI Value;

a Body Mapping Factor Database including body mapping factor values for a population group, wherein each of the body mapping factor values represents a relationship of OCI values between two body areas for the population group and wherein the control unit is configured to select the body mapping factor value based on the locations of the imaging zone and the body part spaced from the imaging zone and modify the Relative OCI Data with the selected body mapping factor value; and

a display adapted to show the modified Relative OCI Data.

17. A method for assessing the blood flow of a body region using optical coherent imaging (OCI) imaging comprising;

illuminating an imaging zone in the body region with coherent light from a coherent light source;

capturing an image from the imaging zone with a light sensor having a two-dimensional array of pixels;

calculating in a processor Absolute OCI Data from the captured image data corresponding to blood flow;

capturing or loading at least one Reference OCI Value associated with blood flow in a body part spaced from the imaging zone;

calculating in the processor Relative OCI Data, said Relative OCI data being proportional to perfusion, velocity and/or concentration of the blood flow in the imaging zone, said Relative OCI data being calculated based on the calculated Absolute OCI Data from the imaging zone modified by the at least one Reference OCI Value;

using a Body Mapping Factor Database including body mapping factor values for a population group, wherein each of the body mapping factor values represents a relationship of OCI values between two body areas for the population group and selecting a body mapping factor value based on the locations of the imaging zone and the body part spaced from the imaging zone and modifying the Relative OCI Data with the selected body mapping factor value; and

displaying the modified Relative OCI Data on a display.

Assignments (18)
CHANGE OF ADDRESS Recorded Dec 18, 2024
From: STRYKER CORPORATION
To: STRYKER CORPORATION
Reel/Frame 069737/0184 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 26, 2023
From: STRYKER EUROPEAN OPERATIONS LIMITED
To: STRYKER CORPORATION
Reel/Frame 066140/0647 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 052873 FRAME: 0548. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 11/30/2017. Recorded May 3, 2021
From: NOVADAQ TECHNOLOGIES ULC
To: STRYKER EUROPEAN HOLDINGS I, LLC
Reel/Frame 056425/0616 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICAITON NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 053318 FRAME: 0612. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 09/05/2018. Recorded May 3, 2021
From: STRYKER EUROPEAN HOLDINGS I, LLC
To: STRYKER EUROPEAN HOLDINGS IV, LLC
Reel/Frame 056425/0731 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 052873 FRAME: 0597. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 09/05/2018. Recorded May 3, 2021
From: STRYKER EUROPEAN HOLDINGS IV, LLC
To: STRYKER EUROPEAN HOLDINGS III, LLC
Reel/Frame 056426/0352 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 053823 FRAME: 0445. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 11/29/2018. Recorded May 3, 2021
From: STRYKER EUROPEAN HOLDINGS III, LLC
To: STRYKER EUROPEAN HOLDINGS LLC
Reel/Frame 056426/0496 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 052860 FRAME: 0900. ASSIGNOR(S) HEREBY CONFIRMS THE NUNC PRO TUNC ASSIGNMENT EFFECTIVE 12/31/2018. Recorded May 3, 2021
From: STRYKER EUROPEAN HOLDINGS LLC
To: STRYKER EUROPEAN OPERATIONS LIMITED
Reel/Frame 056426/0585 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ERRONEOUSLY FILED AGAINST APPLICATION NO. 15/570,072 PREVIOUSLY RECORDED AT REEL: 044910 FRAME: 0507. ASSIGNOR(S) HEREBY CONFIRMS THE MERGER AND CHANGE OF NAME. Recorded May 3, 2021
From: NOVADAQ TECHNOLOGIES INC.
To: NOVADAQ TECHNOLOGIES ULC
Reel/Frame 056425/0530 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: NOVADAQ TECHNOLOGIES ULC
To: STRYKER EUROPEAN HOLDINGS I, LLC
Reel/Frame 052873/0548 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: STRYKER EUROPEAN HOLDINGS LLC
To: STRYKER EUROPEAN OPERATIONS LIMITED
Reel/Frame 052860/0900 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: STRYKER EUROPEAN HOLDINGS IV, LLC
To: STRYKER EUROPEAN HOLDINGS III, LLC
Reel/Frame 052873/0597 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: STRYKER EUROPEAN HOLDINGS I, LLC
To: STRYKER EUROPEAN HOLDINGS IV, LLC
Reel/Frame 053318/0612 →
NUNC PRO TUNC ASSIGNMENT Recorded Jun 7, 2020
From: STRYKER EUROPEAN HOLDINGS III, LLC
To: STRYKER EUROPEAN HOLDINGS LLC
Reel/Frame 053823/0445 →
MERGER AND CHANGE OF NAME Recorded Dec 19, 2017
From: NOVADAQ TECHNOLOGIES INC.; STRYKER CANADA OPERATIONS ULC
To: NOVADAQ TECHNOLOGIES ULC
Reel/Frame 044910/0507 →
RELEASE OF SECURITY INTEREST Recorded Sep 8, 2017
From: MIDCAP FUNDING IV TRUST (AS SUCCESSOR AGENT TO MIDCAP FINANCIAL TRUST)
To: NOVADAQ TECHNOLOGIES INC.; NOVADAQ CORP.
Reel/Frame 043786/0344 →
RELEASE OF SECURITY INTEREST Recorded Sep 8, 2017
From: MIDCAP FINANCIAL TRUST
To: NOVADAQ TECHNOLOGIES INC.; NOVADAQ CORP.
Reel/Frame 043788/0799 →
SECURITY AGREEMENT (REVOLVING) Recorded Jan 9, 2017
From: NOVADAQ TECHNOLOGIES; NOVADAQ CORP.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 041306/0172 →
SECURITY AGREEMENT (TERM) Recorded Jan 9, 2017
From: NOVADAQ TECHNOLOGIES; NOVADAQ CORP.
To: MIDCAP FINANCIAL TRUST, AS AGENT
Reel/Frame 041306/0189 →