Method for producing sepiapterin and tetrahydrolactoylpterin
To provide a method for producing sepiapterin, lactoylpterin or tetrahydrolactoylpterin. Sepiapterin, lactoylpterin and tetrahydrolactoylpterin are produced at high yield through the following reaction scheme.
1. A method for producing sepiapterin represented by formula (3):
or a salt thereof, the method comprising:
subjecting lactoylpterin represented by formula (2):
or a salt thereof to reduction by use of a sulfite, a hyposulfite or a thiosulfate, or catalytic reduction under basic conditions.
2. A method for producing sepiapterin represented by formula (3):
or a salt thereof, the method comprising:
subjecting tetrahydrolactoylpterin represented by formula (4):
or a salt thereof to oxidation by use of a peracid, or air oxidation under neutral or basic conditions.
3. A method for producing tetrahydrolactoylpterin represented by formula (4):
or a salt thereof, the method comprising:
subjecting lactoylpterin represented by formula (2):
or a salt thereof to reduction by use of a BH 3 -based reducing agent, or catalytic reduction under basic conditions.
4. The method according to claim 3 , wherein the reduction reaction is reduction by use of a BH 3 -based reducing agent under acidic conditions, or catalytic reduction under basic conditions.
5. A method for producing sepiapterin represented by formula (3):
or a salt thereof, the method comprising:
subjecting lactoylpterin represented by formula (2):
or a salt thereof to reduction by use of a BH 3 -based reducing agent, or catalytic reduction under basic conditions, to thereby form tetrahydrolactoylpterin represented by formula (4):
or a salt thereof, and
subsequently subjecting the compound (4) to oxidation by use of a peracid, or air oxidation under neutral or basic conditions.
6. The method according to claim 5 , wherein the reduction reaction is reduction by use of a BH 3 -based reducing agent under acidic conditions, or catalytic reduction under basic conditions.