LINGO-2 antagonists for treatment of conditions involving motor neurons
View Patent ↗The invention provides methods of treating diseases, disorders or injuries involving motor neuron survival and axonal growth, including amylotrophic lateral sclerosis, by the administration of a LINGO-2 antagonist. An exemplary method for promoting survival of a motor neuron, comprising contacting said motor neuron with an effective amount of a composition comprising a LINGO-2 antagonist selected from the group consisting of: (i) a soluble LINGO-2 polypeptide; (ii) a LINGO-2 antibody or antigen-binding fragment thereof; (iii) a LINGO-2 antagonist polynucleotide; (iv) a LINGO-2 aptamer; and (v) a combination of two or more of said LINGO-2 antagonists.
1. A method for promoting survival of a motor neuron, comprising contacting said motor neuron with an effective amount of a LINGO-2 antagonist, wherein the LINGO-2 antagonist is an antibody or antigen-binding fragment thereof that binds LINGO-2 but does not bind LINGO-1.
2. A method for promoting axonal growth of a motor neuron, comprising contacting said motor neuron with a LINGO-2 antagonist, wherein the LINGO-2 antagonist is an antibody or antigen-binding fragment thereof that binds LINGO-2 but does not bind LINGO-1.
3. A method for promoting survival of a motor neuron in a human subject in need thereof, comprising administering to the human subject an effective amount of a LINGO-2 antagonist, wherein the LINGO-2 antagonist is an antibody or antigen-binding fragment thereof that binds LINGO-2 but does not bind LINGO-1.
4. The method of claim 3 wherein said human subject has been diagnosed with a disease, disorder, or injury involving motor neurons.
5. A method for promoting axonal growth of a motor neuron in a human subject in need thereof, comprising administering to the human subject an effective amount of a LINGO-2 antagonist, wherein the LINGO-2 antagonist is an antibody or antigen-binding fragment thereof that binds LINGO-2 but does not bind LINGO-1.
6. A method for treating a disease, disorder, or injury associated with survival of a motor neuron in a human subject in need thereof comprising administering to the human subject a therapeutically effective amount of a composition comprising a LINGO-2 antagonist, wherein the LINGO-2 antagonist is an antibody or antigen-binding fragment thereof that binds LINGO-2 but does not bind LINGO-1.
7. The method of claim 6 , wherein said disease, disorder, or injury is selected from the group consisting of amyotrophic lateral sclerosis (ALS), primary lateral sclerosis (PLS), progressive muscular atrophy (PMA), hereditary spastic paraparesis (HSP), X-linked spinobulbar muscular atrophy (SBMA; Kenney disease), progressive bulbar palsy, pseudo-bulbar palsy, spinal muscular atrophy (SMA), post-polio syndrome (PPS), Huntington's disease, Essential tremor (ET), motor neuron disease, paralysis, and Parkinson's disease.
8. The method of claim 7 , wherein said disease, disorder, or injury is amyotrophic lateral sclerosis (ALS).
9. A method for treating a disease, disorder, or injury associated with axonal growth of motor neurons in a human subject in need thereof comprising administering to the human subject a therapeutically effective amount of a composition comprising a LINGO-2 antagonist, wherein the LINGO-2 antagonist is an antibody or antigen-binding fragment thereof that binds LINGO-2 but does not bind LINGO-1.