IP Library Granted Patent US 9,487,835
Granted Patent B2
US 9,487,835 · App. 14/402,485 · Granted Nov 8, 2016

Brassica genomic assays

Inventors: Matthew Curtis Harmon (Elkton, MD); Nancy L Henderson (Landenberg, PA); Cathy Xiaoyan Zhong (Wilmington, DE)
Assignee: E I DU PONT DE NEMOURS AND COMPANY
C12Q1/6895C12Q2600/13C12Q2600/158C12Q2600/166
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Quick Facts
Patent No.
US 9,487,835
App. No.
14/402,485
Granted
Nov 8, 2016
Kind
B2
Abstract

Methods and compositions for detecting, identifying, and quantifying Brassica A genomic DNA are described. The methods are specific to the Brassica A genome and do not cross-react with other Brassica species, crops or weedy relatives that could contribute to contamination of a canola field.

Claims (9)

1. An amplicon comprising at least one of the nucleotide sequences of a genomic region selected from the group consisting of SEQ ID NOS: 26, 27, and 28 wherein the amplicon is not larger than 500 base pairs and further comprising a probe, wherein the probe comprises a fluorescent detectable label and wherein the amplicon discriminates the Brassica A genome from the Brassica B and C genomes.

2. A method of determining a trait purity of a Brassica trait, the method comprising:

a) obtaining a DNA sample of a Brassica plant containing a trait; and

b) performing a Brassica A genome specific assay, wherein the Brassica A genome specific assay comprises:

(i) amplifying a genomic DNA fragment of the Brassica A genome with two or more oligonucleotide primer sequences selected from the group consisting of SEQ ID NOS: 19-24, wherein the amplified DNA fragment comprises at least one of the nucleotide sequences of a genomic region selected from the group consisting of SEQ ID NOS: 25, 26, 27 and 28, and wherein SEQ ID NOS: 25, 26, 27 and 28 of the amplified fragment identifies the presence of Brassica A genome in the sample; and

(ii) detecting the amplified DNA fragment and quantifying the Brassica A genome from the amplified DNA fragment of the Brassica A genome

thereby determining trait purity of the Brassica trait.

3. The method of claim 2 , wherein the Brassica trait is selected from the group consisting of RT73, RT200, MON88302, DP-073496, HCN92, T45 (HCN28), 23-18-17, 23-198, OXY-235, MS1, MS3, MS6, MS8, RF1, RF2, RF3, and Topas 19/2.

4. The method of claim 2 , wherein the determination comprises performing a quantitative polymerase chain reaction.

Assignments (1)
NUNC PRO TUNC ASSIGNMENT Recorded Nov 29, 2022
From: E.I. DU PONT DE NEMOURS AND COMPANY
To: CORTEVA AGRISCIENCE LLC
Reel/Frame 063141/0155 →
Continuity (3)
Provisional Application 61650623 · May 23, 2012
Provisional Application 61777108 · Mar 12, 2013
Related Publication 20150147757A1 · May 28, 2015