IP Library Granted Patent US 9,817,002
Granted Patent B2
US 9,817,002 · App. 14/403,124 · Granted Nov 14, 2017

Molecular discriminators using carbon nanotubes

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Quick Facts
Patent No.
US 9,817,002
App. No.
14/403,124
Granted
Nov 14, 2017
Kind
B2
Abstract

Methods including contacting, in the solid state, a sample comprising a first organic molecule with a composition comprising: a carbon nanotube, such that an interface forms between the sample and the composition; observing any movement of the interface; and characterizing the first organic molecule based on the observed movement are described.

Claims (30)

1. A method comprising:

contacting, in the solid state, a sample comprising a first organic molecule with a composition comprising a carbon nanotube, such that an interface forms between the sample and the composition;

observing any movement of the interface; and

characterizing the first organic molecule based on the observed movement.

2. The method of claim 1 , wherein the first organic molecule is a lipid.

3. The method of claim 2 , wherein the lipid comprises a linear hydrophobic group.

4. The method of claim 2 , wherein the lipid comprises a branched hydrophobic group.

5. The method of claim 1 , wherein the first organic molecule is a phospholipid, glycolipid, sphingolipid, steroid, or a combination of any two or more thereof.

6. The method of claim 1 , wherein the carbon nanotube is a single wall carbon nanotube.

7. The method of claim 1 , wherein the carbon nanotube is a multiwall carbon nanotube.

8. The method of claim 1 , wherein the carbon nanotube is not chemically functionalized prior to contact with the sample.

9. The method of claim 1 , wherein the contacting comprises contacting the sample with the composition at room temperature.

10. The method of claim 1 , wherein the contacting comprises contacting the sample with the composition at about 1 atmosphere pressure.

11. The method of claim 1 , wherein observing any movement comprises observing the movement of the interface via optical microscopy, fluorescence microscopy, Raman microscopy, infra-red imaging, thermal imaging, or a combination of any two or more thereof.

12. The method of claim 1 , wherein observing any movement comprises observing the rate of the movement of the interface.

13. The method of claim 1 , wherein observing any movement of the interface comprises observing the composition moving towards the first organic molecule.

14. The method of claim 1 , further comprising:

contacting, in the solid state, a second sample comprising a second organic molecule with a composition comprising a carbon nanotube, such that a second interface forms between the second sample and the composition;

observing any movement of the second interface; and

distinguishing the second organic molecule from the first organic molecule based on observations of the movements associated with the respective interfaces.

15. A method comprising:

contacting, in the solid state, a sample comprising at least one of (i) an amphiphilic organic molecule and (ii) a non-amphiphilic organic molecule with a composition comprising a carbon nanotube, such that an interface forms between the sample and the composition;

observing any movement of the interface; and

characterizing at least one of the amphiphilic organic molecule and the non-amphiphilic organic molecule based on the observed movement.

16. The method of claim 15 , wherein observing any movement comprises observing diffusion of at least one of (i) the amphiphilic or non-amphiphilic organic molecule and (ii) the composition.

17. The method of claim 15 , wherein the amphiphilic or non-amphiphilic organic molecule is lecithin, dipalmitoyl phosphatidylcholine (DPPC), sphingomyelins, or sphingosine.

18. The method of claim 15 , wherein observing any movement of the interface comprises observing by fluorescence spectroscopy.

19. The method of claim 18 , wherein the observing by fluorescence spectroscopy comprises observing the interface by fluorescence spectroscopy wherein the amphiphilic or non-amphiphilic organic molecule and the composition not at the interface are substantially free of fluorescence.

20. The method of claim 15 , wherein the interface exhibits quantum confinement.

21. The method of claim 15 , wherein the carbon nanotube has a diameter of about 2 to about 3 nm.

Assignments (2)
SECURITY INTEREST Recorded Jan 29, 2019
From: EMPIRE TECHNOLOGY DEVELOPMENT LLC
To: CRESTLINE DIRECT FINANCE, L.P.
Reel/Frame 048373/0217 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 9, 2014
From: DASGUPTA, ANJAN KR.; BHATTACHARYYA, TAMOGHNA
To: UNIVERSITY OF CALCUTTA
Reel/Frame 034438/0839 →