Molecular discriminators using carbon nanotubes
View Patent ↗Methods including contacting, in the solid state, a sample comprising a first organic molecule with a composition comprising: a carbon nanotube, such that an interface forms between the sample and the composition; observing any movement of the interface; and characterizing the first organic molecule based on the observed movement are described.
1. A method comprising:
contacting, in the solid state, a sample comprising a first organic molecule with a composition comprising a carbon nanotube, such that an interface forms between the sample and the composition;
observing any movement of the interface; and
characterizing the first organic molecule based on the observed movement.
2. The method of claim 1 , wherein the first organic molecule is a lipid.
3. The method of claim 2 , wherein the lipid comprises a linear hydrophobic group.
4. The method of claim 2 , wherein the lipid comprises a branched hydrophobic group.
5. The method of claim 1 , wherein the first organic molecule is a phospholipid, glycolipid, sphingolipid, steroid, or a combination of any two or more thereof.
6. The method of claim 1 , wherein the carbon nanotube is a single wall carbon nanotube.
7. The method of claim 1 , wherein the carbon nanotube is a multiwall carbon nanotube.
8. The method of claim 1 , wherein the carbon nanotube is not chemically functionalized prior to contact with the sample.
9. The method of claim 1 , wherein the contacting comprises contacting the sample with the composition at room temperature.
10. The method of claim 1 , wherein the contacting comprises contacting the sample with the composition at about 1 atmosphere pressure.
11. The method of claim 1 , wherein observing any movement comprises observing the movement of the interface via optical microscopy, fluorescence microscopy, Raman microscopy, infra-red imaging, thermal imaging, or a combination of any two or more thereof.
12. The method of claim 1 , wherein observing any movement comprises observing the rate of the movement of the interface.
13. The method of claim 1 , wherein observing any movement of the interface comprises observing the composition moving towards the first organic molecule.
14. The method of claim 1 , further comprising:
contacting, in the solid state, a second sample comprising a second organic molecule with a composition comprising a carbon nanotube, such that a second interface forms between the second sample and the composition;
observing any movement of the second interface; and
distinguishing the second organic molecule from the first organic molecule based on observations of the movements associated with the respective interfaces.
15. A method comprising:
contacting, in the solid state, a sample comprising at least one of (i) an amphiphilic organic molecule and (ii) a non-amphiphilic organic molecule with a composition comprising a carbon nanotube, such that an interface forms between the sample and the composition;
observing any movement of the interface; and
characterizing at least one of the amphiphilic organic molecule and the non-amphiphilic organic molecule based on the observed movement.
16. The method of claim 15 , wherein observing any movement comprises observing diffusion of at least one of (i) the amphiphilic or non-amphiphilic organic molecule and (ii) the composition.
17. The method of claim 15 , wherein the amphiphilic or non-amphiphilic organic molecule is lecithin, dipalmitoyl phosphatidylcholine (DPPC), sphingomyelins, or sphingosine.
18. The method of claim 15 , wherein observing any movement of the interface comprises observing by fluorescence spectroscopy.
19. The method of claim 18 , wherein the observing by fluorescence spectroscopy comprises observing the interface by fluorescence spectroscopy wherein the amphiphilic or non-amphiphilic organic molecule and the composition not at the interface are substantially free of fluorescence.
20. The method of claim 15 , wherein the interface exhibits quantum confinement.
21. The method of claim 15 , wherein the carbon nanotube has a diameter of about 2 to about 3 nm.