IP Library Granted Patent US 9,597,520
Granted Patent B2
US 9,597,520 · App. 14/403,841 · Granted Mar 21, 2017

Electrical stimulation of the carotid artery

Inventors: Ivor Gillbe (Bristol, GB); Nikunj K. Patel (Bristol, GB)
Assignee: Bioinduction Limited
A61N1/3787A61N1/0551A61N1/0558A61N1/3611A61N1/36117A61N1/36125A61N1/37223
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Quick Facts
Patent No.
US 9,597,520
App. No.
14/403,841
Granted
Mar 21, 2017
Kind
B2
Abstract

In order to treat hypertension, an implantable receiving device is connected to implantable leads, which are adapted to deliver electrical energy to the carotid body or bodies of the patient. The receiving device is arranged to receive electrical energy from an external generator. The device thus enables the delivery of electrical currents, which modify the function of neural tissue, particularly where repeated treatments are needed or where positioning of a percutaneous needle is difficult.

Claims (21)

1. A device for treatment of hypertension, asthma, or chronic obstructive pulmonary disease, arranged to supply electrical energy to the carotid body or bodies in the form of a pulsed radio frequency waveform, having a frequency of 200 to 600 kHz comprising:

an external generator;

an implantable receiving device arranged to receive electrical energy from the external generator;

at least one implantable lead connected to the implantable receiving device, the at least one implantable lead being adapted to deliver electrical energy to the carotid body or bodies by means of one or more electrodes at its distal end; and wherein

the carotid body or bodies are located in a saddle of a bifurcation of an internal and an external carotid.

2. The device of claim 1 , wherein the distal end of the at least one implantable lead incorporates a semi-circular hook, in which the semi-circular hook incorporates said one or more electrodes.

3. The device of claim 2 , wherein at least one electrode is connected by an insulated wire of the least one implantable lead to the implantable receiving device such that the at least one electrode can be held in close proximity to the carotid body, such that the electrical energy supplied to the carotid body by the at least one electrode has an electrical return path provided by another electrode of said treatment device.

4. The device of claim 2 , wherein two electrodes form said one or more electrodes, and the two electrodes are present on each side of the semi-circular hook and are connected by insulated wires of the implantable lead to the implantable receiving device such that the electrodes are positioned on each side of the carotid bifurcation.

5. The device of claim 2 , wherein the semi-circular hook allows the at least one implantable lead to be adapted to sit over the bifurcation of the internal and external carotid.

6. The device of claim 5 , wherein the semi-circular shaped hook is formed by a spring so that the hook can be flexible to allow insertion via a tunneling tool.

7. The device of claim 6 , wherein the tunneling tool is one of a hollow hypodermic needle or a guide tube.

8. The device of claim 1 , wherein the implantable receiving device is inductively coupled to the external generator.

9. The device of claim 8 , wherein the implantable receiving device comprises:

a near-infrared light emitting diode for feedback of the voltage at a receiving coil; and

an external transmitting coil that has an infrared photo detector on its surface configured to detect the activation of the implanted near-infrared light emitting diode.

10. The device of claim 9 , wherein the implantable receiving device is arranged to detect the resonance frequency of the receiving coil using the feedback from the near-infrared light emitting diode, and to thereby control the voltage delivered to the electrode of the at least one implantable lead.

11. The device of claim 1 , wherein the implantable receiving device is directly coupled to the external generator.

12. The device of claim 11 , wherein the implantable receiving device incorporates an implantable port comprising a contact of conductive wire mesh enclosed in a low modulus silicone outer case, and a percutaneous needle with insulated shaft with an exposed tip which is inserted into the implantable port to make electrical contact and connected to the external generator.

13. The device of claim 2 , wherein the semi-circular hook is made from an elastic material.

14. The device of claim 1 , wherein the device does not include a temperature sensor.

15. The device of claim 10 , wherein the implantable receiving device further comprises a capacitor connected electrically in parallel to the receiving coil, said capacitor having a resonant frequency of 250-500 kHz.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 3, 2025
From: AMBER THERAPEUTICS LIMITED
To: AMBER THERAPEUTICS HOLDINGS LIMITED
Reel/Frame 070725/0538 →
CHANGE OF NAME Recorded Apr 2, 2025
From: FINETECH MEDICAL LIMITED
To: AMBER THERAPEUTICS LIMITED
Reel/Frame 070710/0848 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 1, 2025
From: BIOINDUCTION LIMITED
To: FINETECH MEDICAL LIMITED
Reel/Frame 070698/0940 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 8, 2017
From: PATEL, NIKUNJ K.
To: BIOINDUCTION LIMITED
Reel/Frame 041662/0879 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 22, 2015
From: GILLBE, IVOR STEPHEN
To: BIOINDUCTION LIMITED
Reel/Frame 034786/0158 →
Priority Claims (1)
GB 1209771.3 · Jun 1, 2012 · national
Continuity (1)
Related Publication 20150112359A1 · Apr 23, 2015