Compounds and compositions for modulating EGFR Activity

1. A compound having Formula (3A) or (3B) or a tautomer thereof:

wherein Ring A is a 5-10 membered heteroaryl comprising 1-4 heteroatoms selected from N, O and S;

Ring B is phenyl;

R 1 and R 1′ are independently hydrogen; halo; cyano; C 1-6 alkyl; C 1-6 haloalkyl; —X 1 —NR 4 R 5 ; —X 1 —OR 3 ; —X 1 —S(O) 0-2 R 6 ; —X 1 —P(O)R 6a R 6b ; phenyl unsubstituted or substituted by C 1-6 alkyl; or a 5-6 membered heteroaryl comprising 1-4 heteroatoms selected from N, O and S;

R 2 is selected from hydrogen, halo; cyano; C 1-6 alkyl; C 1-6 haloalkyl; —X 1 —C(O)OR 3 ; —X 1 —C(O)R 3 ; —X 1 —C(O)NR 4 R 5 ; —X 1 —C(O)NR 4 —X 3 —C(O)OR 3 ; —X 1 —C(O)NR 4 —X 3 —S(O) 0-2 R 6 ; —X 1 —NR 4 R 5 ; —X 1 —NR 4 —X 2 —C(O)R 3 ; —X 1 —NR 4 —X 3 —S(O) 0-2 R 6 ; —X 1 —OR 3 ; —X 1 —O—X 1 —OR 3 ; —X 1 —S(O) 0-2 R 6 ; —X 1 —O—X 4 —NR 4 R 5 ; or a 5-6 membered heteroaryl comprising 1-4 heteroatoms selected from N, O and S and is unsubstituted or substituted by C 1-6 alkyl;

X 1 and X 2 are independently a bond or C 1-6 alkyl;

X 3 is C 1-6 alkyl;

X 4 is C 2-6 alkyl;

R 3 , R 4 and R 5 are independently hydrogen, C 1-6 alkyl or C 1-6 haloalkyl; or wherein R 4 and R 5 together with N in NR 4 R 5 may form a 4-7 membered ring containing 1-2 heteroatoms selected from N, O, and S, and optionally substituted with 1-4 R 7 groups;

R 6 , R 6a and R 6b are C 1-6 alkyl;

R 8 is

R 12 , R 13 , R 16 and R 17 are independently hydrogen or C 1-6 alkyl;

R 14 and R 15 are independently hydrogen; C 1-6 alkyl; —C(O)O—(C 1-6 alkyl); C 3-7 cycloalkyl unsubstituted or substituted with C 1-6 alkyl; or R 14 and R 15 together with N in NR 14 R 15 may form may form a 4-7 membered ring containing 1-2 heteroatoms selected from N, O and S, and optionally substituted with 1-4 R 18 groups;

R 7 and R 18 are independently oxo, halo, hydroxy, C 1-6 alkyl or C 1-6 alkoxy;

n is independently 1-3; and

m and q are independently 1-2;

or a pharmaceutically acceptable salt thereof.

2. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein: Ring A is pyridyl, pyrimidinyl, pyridazinyl, pyrazinyl, oxazolyl, furanyl, thiazolyl, imidazole[2,1-b][1,3]thiazolyl, imidazo[1,2-a]pyridinyl, imidazo[1,5-a]pyridinyl, each of which is unsubstituted or substituted by (R 1 ) n and R 1′ ; and

R 1 , R 1′ and n are as defined in claim 1 .

3. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein said compound is of Formula (5):

wherein one of W 1 and W 2 is CR 1 and the other is N; and

R 1 , R 1′ , R 2 , R 8 and m are as defined in claim 1 .

4. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 and R 1′ are independently hydrogen; halo; cyano; C 1-6 alkyl; C 1-6 haloalkyl; —X 1 —NR 4 R 5 ; —X 1 —OR 3 ; —X 1 —S(O) 0-2 R 6 ; phenyl unsubstituted or substituted by C 1-6 alkyl; tetrazolyl or pyrrolyl;

each X 1 is a bond or CH 2 ;

R 3 , R 4 and R 5 are independently hydrogen, C 1-6 alkyl or C 1-6 haloalkyl; or wherein R 4 and R 5 together with N in NR 4 R 5 form piperidinyl; and

R 6 is as defined in claim 1 .

5. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 is hydrogen, halo, cyano, C 1-6 alkyl, C 1-6 haloalkyl, tetrazolyl, pyrrolyl, —X 1 —NR 4 R 5 , —X 1 —OR 3 , —X 1 —S(O) 0-2 R 6 or phenyl unsubstituted or substituted by C 1-6 alkyl;

R 1′ is hydrogen, halo or C 1-6 alkyl;

R 3 , R 4 and R 5 are independently hydrogen, C 1-6 alkyl or C 1-6 haloalkyl; or wherein R 4 and R 5 together with N in NR 4 R 5 form piperidinyl;

X 1 is a bond or CH 2 ; and

R 6 is as defined in claim 1 .

6. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 1 and R 1′ are independently hydrogen; methyl; t-butyl; trifluoromethyl; methoxy; ethoxy; trifluoromethoxy; difluoromethoxy; fluoro; chloro; cyano; dimethylamino; methylsulfonyl; dimethylphosphoryl; tetrazolyl; pyrrolyl; phenyl unsubstituted or substituted by methyl; or piperidin-1-yl.

7. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein:

R 2 is hydrogen; chloro; methyl; trifluoromethyl; methoxy; isoproproxy; cyano; hydroxymethyl; methoxymethyl; ethoxymethyl; methylsulfonyl; methylcarbonyl; carboxy; methoxycarbonyl; carbamoyl; dimethylaminomethyl; pyrrolidin-1-ylmethyl unsubstituted or substituted by 1-2 hydroxy, halo or methoxy; morpholin-4-ylmethyl; azetidin-1-ylmethyl unsubstituted or substituted by 1-2 halo or methoxy; piperidin-1-ylmethyl; ((4-methyl-3-oxo-piperazin-1-yl)methyl); (1,1-dioxidothiomorpholine-4-carbonyl); pyrrolidin-1-yl carbonyl unsubstituted or substituted by 1-2 hydroxy; pyrrolidin-1-ylethoxy; (1,1-dioxido-thiomorpholin-4-yl)methyl; or 1,2,4-oxadiazolyl unsubstituted or substituted by C 1-6 alkyl;

alternatively, R 2 is —CH 2 —N(CH 3 )—C(O)—CH 3 ; —CH 2 —O—(CH 2 ) 2 —OCH 3 ;

—CH 2 —N(CH 3 )—(CH 2 ) 2 —SO 2 (CH 3 ); —C(O)NH—(CH 2 ) 1-2 —C(O)—OCH 3 ;

—C(O)NH—(CH 2 ) 1-2 —C(O)OH; or —C(O)NH—(CH 2 ) 2 —SO 2 (CH 3 ).

8. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein R 8 is

wherein R 14 and R 15 are independently hydrogen, C 1-6 alkyl or C 3-7 cycloalkyl; or R 14 and R 15 together with N in NR 14 R 15 may form an azetidinyl, piperidyl, pyrrolidinyl or morpholinyl; where said azetidinyl or pyrrolidinyl can be optionally substituted with 1-2 halo, methoxy or hydroxyl; and

R 12 , R 13 , R 16 , R 17 and q are as defined in claim 1 .

9. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein said compound is selected from:

N-{7-chloro-1-[(3R)-1-[4-(pyrrolidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[4-(pyrrolidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[4-(3-fluoroazetidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[4-(3-fluoroazetidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-{4-[(3R)-3-fluoropyrrolidin-1-yl]but-2-enoyl}azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-{4-[3-fluoropyrrolidin-1-yl]but-2-enoyl}azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-{4-[(3S)-3-fluoropyrrolidin-1-yl]but-2-enoyl}azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[4-(3,3-difluoropyrrolidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[4-(3,3-difluoropyrrolidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-{4-[(3R)-3-methoxypyrrolidin-1-yl]but-2-enoyl}azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-{4-[3-methoxypyrrolidin-1-yl]but-2-enoyl}azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-{4-[(3S)-3-methoxypyrrolidin-1-yl]but-2-enoyl}azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-{4-[(3R)-3-hydroxypyrrolidin-1-yl]but-2-enoyl}azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-{4-[3-hydroxypyrrolidin-1-yl]but-2-enoyl}azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-[(3S)-3-hydroxypyrrolidin-1-yl]but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-[3-hydroxypyrrolidin-1-yl]but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-(pyrrolidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-(pyrrolidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

2-methyl-N-{7-methyl-1-[(3R)-1-[(2E)-4-(pyrrolidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

2-methyl-N-{7-methyl-1-[1-[(2E)-4-(pyrrolidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-[(3R)-3-fluoropyrrolidin-1-yl]but-2-enoyl]azepan-3-yl]-7-methyl-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[1-[(2E)-4-[3-fluoropyrrolidin-1-yl]but-2-enoyl]azepan-3-yl]-7-methyl-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-[(3R)-3-fluoropyrrolidin-1-yl]but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-[3-fluoropyrrolidin-1-yl]but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[(3R)-1-[4-(azetidin-1-yl)but-2-enoyl]azepan-3-yl]-7-chloro-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[1-[4-(azetidin-1-yl)but-2-enoyl]azepan-3-yl]-7-chloro-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[4-(3-hydroxyazetidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[4-(3-hydroxyazetidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-(3-methoxyazetidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-(3-methoxyazetidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-(3,3-difluoroazetidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-(3,3-difluoroazetidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-(trifluoromethyl)pyridine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-(trifluoromethyl)pyridine-4-carboxamide;

N-{7-chloro-6-methoxy-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-chloro-6-methoxy-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-6-methoxy-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-6-methoxy-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-1,3-oxazole-5-carboxamide;

N-{7-chloro-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-chloro-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyridine-3-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyridazine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyridine-2-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyridine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyrimidine-2-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyrimidine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyrazine-2-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyridazine-3-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-6-methoxypyridine-3-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-6-(trifluoromethyl)pyridine-3-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-6-methylpyridine-3-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-2-methoxypyridine-4-carboxamide;

2-(dimethylamino)-N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyridine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)imidazo[2,1-b][1,3]thiazole-6-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-2-methylpyrimidine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)imidazo[1,2-a]pyridine-6-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)furan-2-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-2-(piperidin-1-yl)pyridine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-2-fluoropyridine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-4,5-dimethylfuran-2-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-2-(1H-1,2,3,4-tetrazol-1-yl)pyridine-4-carboxamide;

2-tert-butyl-N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)pyridine-4-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-2-methylpyridine-3-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)imidazo[1,5-a]pyridine-7-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-2-methyl-1,3-thiazole-5-carboxamide;

N-(1-{1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl}-7-methyl-H-1,3-benzodiazol-2-yl)-2-ethoxypyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-(trifluoromethyl)pyridine-3-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-(trifluoromethyl)pyridine-3-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-methylpyridine-3-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-methylpyridine-3-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-fluoropyridine-3-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-fluoropyridine-3-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-(1H-pyrrol-1-yl)pyridine-3-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-(1H-pyrrol-1-yl)pyridine-3-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-methoxypyridine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-methoxypyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

2-chloro-N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

2-chloro-N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

2-chloro-N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-6-methylpyridine-4-carboxamide;

2-chloro-N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-6-methylpyridine-4-carboxamide;

2-chloro-N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-6-methoxypyridine-4-carboxamide;

2-chloro-N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-6-methoxypyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-phenylpyridine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-phenylpyridine-4-carboxamide;

6-chloro-N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridine-3-carboxamide;

6-chloro-N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridine-3-carboxamide;

5,6-dichloro-N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-1H-1,3-benzodiazol-2-yl}pyridine-3-carboxamide;

5,6-dichloro-N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-1H-1,3-benzodiazol-2-yl}pyridine-3-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-methoxypyridine-3-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-5-methoxypyridine-3-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-(2-methylphenyl)pyridine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-(2-methylphenyl)pyridine-4-carboxamide;

6-methyl-N-{7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

6-methyl-N-{7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-6-methylpyridazine-4-carboxamide;

N-{1-[I-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-6-methylpyridazine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methoxy-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methoxy-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methoxy-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methoxy-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-(propan-2-yloxy)-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-(propan-2-yloxy)-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-7-(propan-2-yloxy)-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[1-(prop-2-enoyl)azepan-3-yl]-7-(propan-2-yloxy)-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[(3R)-1-[4-(dimethylamino)but-2-ynoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[1-[4-(dimethylamino)but-2-ynoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

(R)—N-(7-methyl-1-(1-(2-methyl-4,4-dioxido-5,6-dihydro-1,4-oxathiine-3-carbonyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)pyridazine-4-carboxamide;

N-(7-methyl-1-(1-(2-methyl-4,4-dioxido-5,6-dihydro-1,4-oxathiine-3-carbonyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)pyridazine-4-carboxamide;

N-{1-[(3R)-1-[(5,6-dihydro-1,4-dioxin-2-yl)carbonyl]azepan-3-yl]-7-methyl-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[1-[(5,6-dihydro-1,4-dioxin-2-yl)carbonyl]azepan-3-yl]-7-methyl-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methyl-1-[(3R)-1-[2-(piperidin-1-ylmethyl)prop-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methyl-1-[1-[2-(piperidin-1-ylmethyl)prop-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methyl-1-[(3R)-1-[2-(pyrrolidin-1-ylmethyl)prop-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methyl-1-[1-[2-(pyrrolidin-1-ylmethyl)prop-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[(3R)-1-{2-[(diethylamino)methyl]prop-2-enoyl}azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[1-{2-[(diethylamino)methyl]prop-2-enoyl}azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methyl-1-[(3R)-1-[2-(morpholin-4-ylmethyl)prop-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methyl-1-[1-[2-(morpholin-4-ylmethyl)prop-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-(trifluoromethoxy)pyridine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-(trifluoromethoxy)pyridine-4-carboxamide;

2-(difluoromethoxy)-N-{1-[(3R)-1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-1H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

2-(difluoromethoxy)-N-{1-[1-[4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

2-chloro-N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-6-(trifluoromethoxy)pyridine-4-carboxamide;

2-chloro-N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-6-(trifluoromethoxy)pyridine-4-carboxamide;

2,6-dimethyl-N-{7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-5-(pyrrolidin-1-ylmethyl)-1H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

2,6-dimethyl-N-{7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-5-(pyrrolidin-1-ylmethyl)-1H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

2-methyl-N-{7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-5-(pyrrolidin-1-ylmethyl)-1H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

2-methyl-N-{7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-5-(pyrrolidin-1-ylmethyl)-1H-1,3-benzodiazol-2-yl}pyridine-4-carboxamide;

2-methyl-N-[7-methyl-5-(piperidin-1-ylmethyl)-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl]pyridine-4-carboxamide;

2-methyl-N-[7-methyl-5-(piperidin-1-ylmethyl)-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl]pyridine-4-carboxamide;

N-[5-(azetidin-1-ylmethyl)-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl]-2-methylpyridine-4-carboxamide;

N-[5-(azetidin-1-ylmethyl)-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl]-2-methylpyridine-4-carboxamide;

N-(5-{[(3S)-3-hydroxypyrrolidin-1-yl]methyl}-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2-methylpyridine-4-carboxamide;

N-(5-{[3-hydroxypyrrolidin-1-yl]methyl}-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2-methylpyridine-4-carboxamide;

N-(5-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2-methylpyridine-4-carboxamide;

N-(5-{[3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2-methylpyridine-4-carboxamide;

N-(5-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2-methylpyridine-4-carboxamide;

N-(5-{[(3S)-3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2-methylpyridine-4-carboxamide;

N-(5-{[3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2-methylpyridine-4-carboxamide;

N-(5-{[(3R)-3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2-methylpyridine-4-carboxamide;

N-{5-[(3,3-difluoropyrrolidin-1-yl)methyl]-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{5-[(3,3-difluoropyrrolidin-1-yl)methyl]-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{5-[(3-fluoroazetidin-1-yl)methyl]-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{5-[(3-fluoroazetidin-1-yl)methyl]-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{5-[(3,3-difluoroazetidin-1-yl)methyl]-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{5-[(3,3-difluoroazetidin-1-yl)methyl]-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{5-[(3-methoxyazetidin-1-yl)methyl]-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{5-[(3-methoxyazetidin-1-yl)methyl}-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl-2-methylpyridine-4-carboxamide;

N-(5-{[(3S)-3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2,6-dimethylpyridine-4-carboxamide;

N-(5-{[3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2,6-dimethylpyridine-4-carboxamide;

N-(5-{[(3R)-3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2,6-dimethylpyridine-4-carboxamide;

N-(5-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2,6-dimethylpyridine-4-carboxamide;

N-(5-{[3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2,6-dimethylpyridine-4-carboxamide;

N-(5-{[(3R)-3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2,6-dimethylpyridine-4-carboxamide;

6-methyl-N-{7-methyl-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-5-(pyrrolidin-1-ylmethyl)-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

6-methyl-N-{7-methyl-1-[1-(prop-2-enoyl)azepan-3-yl]-5-(pyrrolidin-1-ylmethyl)-1H-1,3-benzodiazol-2-yl}pyridazine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-but-2-enoyl]azepan-3-yl]-5-{[(3S)-3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

N-{1-[1-[(2E)-but-2-enoyl]azepan-3-yl]-5-{[3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-but-2-enoyl]azepan-3-yl]-5-{[(3R)-3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[1-[(2E)-but-2-enoyl]azepan-3-yl]-5-{[3-methoxypyrrolidin-1-yl]methyl}-7-methyl-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-but-2-enoyl]azepan-3-yl]-7-methyl-5-(pyrrolidin-1-ylmethyl)-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[1-[(2E)-but-2-enoyl]azepan-3-yl]-7-methyl-5-(pyrrolidin-1-ylmethyl)-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-but-2-enoyl]azepan-3-yl]-5-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

N-{1-[1-[(2E)-but-2-enoyl]azepan-3-yl]-5-{[3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-but-2-enoyl]azepan-3-yl]-5-{[(3S)-3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[1-[(2E)-but-2-enoyl]azepan-3-yl]-5-{[3-fluoropyrrolidin-1-yl]methyl}-7-methyl-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-(5-{[(3S)-3-methoxypyrrolidin-1-yl]methyl}-1-[(3R)-1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2,6-dimethylpyridine-4-carboxamide;

N-(5-{[3-methoxypyrrolidin-1-yl]methyl}-1-[1-(prop-2-enoyl)azepan-3-yl]-1H-1,3-benzodiazol-2-yl)-2,6-dimethylpyridine-4-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methoxy-H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methoxy-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-6-methoxy-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{7-chloro-1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-6-methoxy-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{6-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-5-methoxy-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{6-chloro-1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-5-methoxy-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

N-{6-chloro-1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-5-methoxy-1H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

N-{6-chloro-1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-5-methoxy-1H-1,3-benzodiazol-2-yl}-2,6-dimethylpyridine-4-carboxamide;

N-{1-[(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-(trifluoromethyl)pyridine-4-carboxamide;

N-{1-[(3S)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-methyl-1,3-thiazole-5-carboxamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-methyl-1,3-thiazole-5-carboxamide;

N-{1-[1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-methyl-1,3-thiazole-5-carboxamide;

(R)—N-(7-chloro-1-(1-(1-methyl-1,2,5,6-tetrahydropyridine-3-carbonyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(N-(7-chloro-1-(1-(1-methyl-1,2,5,6-tetrahydropyridine-3-carbonyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R)—N-(7-chloro-1-(1-(1-methyl-1,2,3,6-tetrahydropyridine-4-carbonyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(7-chloro-1-(1-(1-methyl-1,2,3,6-tetrahydropyridine-4-carbonyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)-4-methylpent-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(7-chloro-1-(1-(4-(dimethylamino)-4-methylpent-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R)—N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(2-(pyrrolidin-1-yl)ethoxy)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(2-(pyrrolidin-1-yl)ethoxy)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

(R,E)-N-(7-chloro-1-(1-(4-(dicyclopropylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(7-chloro-1-(1-(4-(dicyclopropylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R)—N-(1-(1-acryloylazepan-3-yl)-7-methyl-5-((4-methyl-3-oxopiperazin-1-yl)methyl)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

N-(1-(1-acryloylazepan-3-yl)-7-methyl-5-((4-methyl-3-oxopiperazin-1-yl)methyl)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

(E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-(dimethylphosphoryl)-6-methylisonicotinamide;

N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-(dimethylphosphoryl)-6-methylisonicotinamide;

(R,E)-tert-butyl 4-(3-(7-chloro-2-(2-methylisonicotinamido)-1H-benzo[d]imidazol-1-yl)azepan-1-yl)-4-oxobut-2-enyl(methyl)carbamate;

tert-butyl 4-(3-(7-chloro-2-(2-methylisonicotinamido)-1H-benzo[d]imidazol-1-yl)azepan-1-yl)-4-oxobut-2-enyl(methyl)carbamate;

(R,E)-N-(7-chloro-1-(1-(4-(methylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(7-chloro-1-(1-(4-(methylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R,E)-N-(7-chloro-1-(1-(4-(methylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

N-(7-chloro-1-(1-(4-(methylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

(R,E)-N-(1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-7-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-7-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R,E)-N-(1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-7-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

N-(1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-7-(trifluoromethyl)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

(R,E)-N-(7-chloro-1-(1-(4-(cyclopropylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(7-chloro-1-(1-(4-(cyclopropylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R,E)-N-(1-(1-(4-(tert-butylamino)but-2-enoyl)azepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(1-(1-(4-(tert-butylamino)but-2-enoyl)azepan-3-yl)-7-chloro-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R,E)-N-(7-chloro-1-(1-(4-(1-methylcyclopropylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(7-chloro-1-(1-(4-(1-methylcyclopropylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R)—N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(2-(pyrrolidin-1-yl)ethoxy)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(2-(pyrrolidin-1-yl)ethoxy)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R,E)-N-(1-(1-but-2-enoylazepan-3-yl)-7-chloro-6-(2-(pyrrolidin-1-yl)ethoxy)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(1-(1-but-2-enoylazepan-3-yl)-7-chloro-6-(2-(pyrrolidin-1-yl)ethoxy)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R,E)-N-(1-(1-but-2-enoylazepan-3-yl)-7-chloro-6-(2-(pyrrolidin-1-yl)ethoxy)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

N-(1-(1-but-2-enoylazepan-3-yl)-7-chloro-6-(2-(pyrrolidin-1-yl)ethoxy)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-(dimethylphosphoryl)-6-methylisonicotinamide;

N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl) 1H-benzo[d]imidazol-2-yl)-2-(dimethylphosphoryl)isonicotinamide; and

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-(dimethylphosphoryl)isonicotinamide.

10. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein said compound is N-{7-chloro-1-[(3R)-1-[4-(pyrrolidin-1-yl)but-2-enoyl]azepan-3-yl]-1H-1,3-benzodiazol-2-yl}-2-methylpyridine-4-carboxamide;

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide;

(R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide;

N-{1-[(3R)-1-[(2E)-4-(dimethylamino)but-2-enoyl]azepan-3-yl]-7-methyl-H-1,3-benzodiazol-2-yl}-2-(trifluoromethyl)pyridine-4-carboxamide;

(R)—N-(1-(1-acryloylazepan-3-yl)-7-chloro-6-(2-(pyrrolidin-1-yl)ethoxy)-1H-benzo[d]imidazol-2-yl)-2,6-dimethylisonicotinamide; or

(R,E)-N-(7-chloro-1-(1-(4-(methylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide.

11. The compound of claim 1 or a pharmaceutically acceptable salt thereof, wherein said compound is (R,E)-N-(7-chloro-1-(1-(4-(dimethylamino)but-2-enoyl)azepan-3-yl)-1H-benzo[d]imidazol-2-yl)-2-methylisonicotinamide.

12. The compound of claim 11 , wherein said compound is in the form of a salt selected from hydrochloric acid salt, mesylate, tosylate, bromide, maleate and nitrate.

13. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

14. A pharmaceutical composition comprising a compound of claim 9 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

15. A pharmaceutical composition comprising a compound of claim 10 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

16. A pharmaceutical composition comprising a compound of claim 11 or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

17. A method for treating a condition mediated by epidermal growth factor receptor (EGFR), comprising administering to a subject in need of treatment an effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof; wherein said condition mediated by EGFR is non-small cell lung cancer (NSCLC), head and neck cancer, colorectal cancer, breast cancer, pancreatic cancer, ovarian cancer, gastric cancer, glioma, prostate cancer or a solid tumor.

18. The method of claim 17 , wherein said condition mediated by EGFR is non-small cell lung cancer (NSCLC).

19. The method of claim 17 , wherein said condition mediated by EGFR is colorectal cancer.

20. The method of claim 17 , wherein said EGFR is a mutant EGFR comprising G719S, G719C, G719A, L858R, L861Q, an exon 19 deletion mutation or an exon 20 insertion mutation.

21. The method of claim 20 , wherein said EGFR is a mutant EGFR comprising an EGFR T790M, T854A or D761Y resistance mutation.