IP Library Granted Patent US 10,420,499
Granted Patent B2
US 10,420,499 · App. 14/407,249 · Granted Sep 24, 2019

Method and system of detecting seizures

Inventor: Isa Conradsen (København S, DK)
Assignee: Brain Sentinel, Inc.
A61B5/4094A61B5/04014A61B5/0488A61B5/7246
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Quick Facts
Patent No.
US 10,420,499
App. No.
14/407,249
Granted
Sep 24, 2019
Kind
B2
Abstract

A system and method for detecting and analyzing the characteristics of seizures, such as tonic-clonic seizures, comprising at least one processor unit capable of recording a signal from a sensor unit, one or more analysis modules configured to analyze the recorded signal, one or more evaluation modules configured to evaluate the output signals from the analysis modules. A first analysis module is configured to analyze the recorded signal within a first frequency band, and a second analysis module is configured to analyze the recorded signal within a second frequency band, and the evaluation module is configured to calculate the ratio between the two output signals from the analysis modules. The system includes a seizure detection module configured to detect a seizure and a time-point extraction module configured to determine at least one starting point and an end point of the seizure.

Claims (26)

1. A system for detecting seizures, such as tonic-clonic seizures, and generating an alarm signal in response to a detected seizure, the system comprising:

a portable electromyography sensor unit including surface electrodes;

at least one processor unit capable of recording an electromyography signal from said portable electromyography sensor unit, the at least one processor unit including a filter module, a first analysis module, a second analysis module, an evaluation module, and a seizure detection module;

the filter module configured to select each of a first frequency band and a second frequency band, the bandwidth of the first frequency band selected to collect muscle related signals in the tonic phase of a generalized tonic-clonic seizure, the bandwidth of the second frequency band selected to collect muscle related signals in the clonic phase of a generalized tonic-clonic seizure;

said first analysis module configured to analyze the recorded electromyography signal within said first frequency band over a range of 32-512 Hz to provide a first output signal, and said second analysis module configured to analyze the recorded electromyography signal within said second frequency band over a range of 2-16 Hz to provide a second output signal;

said evaluation module configured to calculate a ratio (HF/LF) between said first output signal of the first analysis module and said second output signal of the second analysis module; and

said seizure detection module configured to compare the ratio (HF/LF) to a first threshold value and to generate an alarm signal if the ratio (HF/LF) exceeds the first threshold value.

2. A system according to claim 1 , wherein the seizure detection module is configured to further compare one of the first or second output signals to a second threshold value and to generate the alarm signal if the first or second output signal exceeds the second threshold value.

3. A system for determining the dynamics of seizures, such as tonic-clonic seizures, the system comprising:

a portable electromyography sensor unit including surface electrodes;

at least one processor unit capable of recording an electromyography signal from said portable electromyography sensor unit, the at least one processor unit including a filter module, a first analysis module, a second analysis module, and a time-point extraction module;

the filter module configured to select each of a first frequency band and a second frequency band, the bandwidth of the first frequency band selected to collect muscle related signals in the tonic phase of a generalized tonic-clonic seizure, the bandwidth of the second frequency band selected to collect muscle related signals in the clonic phase of a generalized tonic-clonic seizure;

said first analysis module configured to analyze the recorded electromyography signal within said first frequency band over a range of 32-512 Hz to provide a first output signal, and said second analysis module configured to analyze the recorded electromyography signal within said second frequency band over a range of 2-16 Hz to provide a second output signal;

said time point extraction configured to compare one of the first or the second output signals to a threshold value and to determine a starting point of a seizure event phase in a detected seizure based on the threshold value.

4. A system according to claim 3 , wherein the time-point extraction module is further configured to apply a zero-crossing function to the other one of the first or second output signals and to count the number of crossings within a predetermined time window.

5. A system according to claim 4 , wherein the time-point extraction module is configured to compare the count to a second threshold value and to determine at least one time point of the detected seizure based on the second threshold value.

6. A system according to claim 1 , wherein a third analysis module is configured to calculate an average of the electromyography signal within a second predetermined time window, and where a second evaluation module is configured to calculate the slope of the average of the electromyography signal during the beginning of the seizure.

7. A system according to claim 1 , wherein a fourth analysis module is configured to apply a Fourier transformation function to the electromyography signal to provide a transformed electromyography signal, and where a third evaluation module is configured to calculate the median frequency within a third predetermined time window based on the transformed electromyography signal.

8. A system according to claim 1 , wherein the processor unit is configured to receive a control signal and where the processor unit is configured to record the signal for a predetermined time period at least after receiving the control signal.

9. A system according to claim 8 , wherein the time-point extraction module is configured to determine at least the length of the seizure based on the electromyography signal.

10. A method of analyzing the dynamics of seizures, such as tonic-clonic seizures, comprising:

measuring an electromyography signal using a portable electromyography sensor unit, including surface electrodes;

recording said electromyography signal from said portable electromyography sensor unit using at least one processor unit, the at least one processor unit including a filter module, a first analysis module, a second analysis module, and a time-point extraction module;

wherein the electromyography signal is filtered using said filter module to select each of a first frequency band and a second frequency band, the bandwidth of the first frequency band selected to collect muscle related signals in the tonic phase of a generalized tonic-clonic seizure, the bandwidth of the second frequency band selected to collect muscle related signals in the clonic phase of a generalized tonic-clonic seizure;

analyzing the electromyography signal using said first analysis module and said second analysis module, said first analysis module analyzing the electromyography signal within said first frequency band over a range of 32-512 Hz to provide a first output signal, and said second analysis module analyzing the electromyography signal within said second frequency band over a range of 2-16 Hz to provide a second output signal; and

comparing one of the first or the second output signals to a threshold value to determine a starting point of a seizure event phase in a detected seizure based on said threshold value using said time-point extraction module.

Assignments (5)
SECURITY INTEREST Recorded Aug 8, 2022
From: NOVELA NEUROTECHNOLOGIES, INC.
To: HCV INVESTMENTS, LLC
Reel/Frame 060746/0143 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 1, 2022
From: HCV INVESTMENTS, LLC
To: NOVELA NEUROTECHNOLOGY
Reel/Frame 060065/0971 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 27, 2022
From: BRAIN SENTINEL, INC.
To: HCV INVESTMENTS, LLC
Reel/Frame 060043/0697 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2018
From: ICTALCARE A/S
To: BRAIN SENTINEL, INC.
Reel/Frame 044759/0410 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 11, 2014
From: CONRADSEN, ISA
To: ICTALCARE A/S
Reel/Frame 034480/0310 →
Priority Claims (1)
DK 2012 70323 · Jun 12, 2012 · national
Continuity (1)
Related Publication 20150119746A1 · Apr 30, 2015