Pharmaceutical compositions and treatment of mastitis
View Patent ↗The present invention relates to a pharmaceutical composition and methods of treating and/or preventing mastitis in non-human mammals. More particularly, the present invention relates to the treatment of mastitis in cows. The pharmaceutical composition comprises a mixture of a phosphonic acid and at least one antimicrobial.
1. An intra-mammary pharmaceutical composition for use in the treatment or prevention of mastitis in a non-human mammal, comprising a pharmaceutical composition of a phosphonic acid with a dosage of 500 to about 2000 mg and at least one antimicrobial with a dosage of about 10 to about 1000 mg,
wherein the phosphonic acid is selected from the group consisting of fosfomycin, alafosfalin, and pharmaceutically acceptable salt thereof, and
wherein the antimicrobial is selected from the group consisting of enrofloxacin, moxifloxacin, pradofloxacin, β-lactams, and macrolide-streptogramin-lincosamides, or a pharmaceutically acceptable salt thereof.
2. The composition of claim 1 , wherein the antimicrobial is a β-lactam with a dosage of about 200 to about 800 mg.
3. The composition of claim 2 , wherein the β-lactam is selected from the group consisting of a penicillin, cephalosporin, carbapenem and penem, and β-lactamase inhibitor.
4. The composition of claim 3 , wherein the β-lactam is cephalosporin.
5. The composition of claim 4 , wherein the cephalosporin is cefazolin in a dosage of about 200 mg to about 800 mg.
6. The intra-mammary pharmaceutical composition according to claim 4 , wherein the phosphonic acid is fosfomycin or fosfomycin salt and wherein the cephalosporin is in a dosage of about 200 to about 800 mg.
7. The intra-mammary pharmaceutical composition according to claim 4 , wherein the cephalosporin is cefazolin or a pharmaceutically acceptable salt thereof and wherein the phosphonic acid is fosfomycin or a pharmaceutically acceptable salt thereof.
8. The intra-mammary pharmaceutical composition according to claim 4 , wherein the cephalosporin is cefazolin.
9. The composition of claim 3 , wherein the β-lactam is penicillin.
10. The composition of claim 1 , wherein the antimicrobial is a macrolide-streptogramin-lincosamide with a dosage of about 25 to about 100 mg.
11. A method for treating mastitis comprising administering to one udder quarter of a non-human mammal having mastitis the pharmaceutical composition according to claim 1 .
12. The intra-mammary pharmaceutical composition according to claim 1 , comprising a macrolide-streptogramin-lincosamide selected from the group consisting of a macrolide, lincomycin, clindamycin, and pirlimycin.
13. The intra-mammary pharmaceutical composition according to claim 1 , wherein the phosphonic acid is fosfomycin or a pharmaceutically acceptable salt thereof.
14. The intra-mammary pharmaceutical composition according to claim 13 , wherein the antimicrobial is amoxicillin or a pharmaceutically acceptable salt thereof.
15. The intra-mammary pharmaceutical composition according to claim 1 , wherein the antimicrobial is enrofloxacin or a pharmaceutically acceptable salt thereof.
16. The intra-mammary pharmaceutical composition according to claim 1 , wherein the antimicrobial is macrolide-streptogramin-lincosamide or a pharmaceutically acceptable salt thereof.
17. The intra-mammary pharmaceutical composition according to claim 16 , wherein the macrolide-streptogramin-lincosamide is pirlimycin.
18. The intra-mammary pharmaceutical composition according to claim 1 , wherein the composition has a synergistic effect.
19. The intra-mammary pharmaceutical composition according to claim 1 , wherein the phosphonic acid is alafosfalin or a pharmaceutically acceptable salt thereof.