Processing of fluids containing interfering particles
The invention relates to a method and a processing device for the processing of a fluid containing interfering particles (C). Magnetic particles (MP) are added to the fluid in a processing chamber and distributed, in part, using a magnetic field to provide a blocking zone (BZ) within the processing chamber to impede or prevent such migration of the interfering particles (C) through the processing chamber. The blocking zone (BZ) hence acts as a filter element by which interfering particles (C) can for example be kept away from a detection region at the surface of the processing chamber.
1. A device for processing a fluid containing interfering particles (C), the device comprising:
a processing chamber containing the fluid and magnetic particles (MP, MPB), the processing chamber comprising a blocking zone (BZ, BZ′) formed by distribution of the magnetic particles for physically imped the interfering particles to filter out and control distribution of the interfering particles within the processing chamber during the processing of the fluid to alter interference caused by the interfering particles; and
a magnetic field generator for generating a magnetic field that provides, at least in part, the distribution of the magnetic particles (MP, MPB) forming the blocking zone (BZ, BZ′) within the processing chamber,
wherein the mean distance between the magnetic particles (MP, MPB) and/or clusters (CL) of the magnetic particles of the blocking zone (BZ, BZ′) is less than or equal to about five times the mean diameter of the interfering particles (C).
2. The device according to claim 1 , wherein a surface of the processing chamber comprises a processing region in which the processing of the fluid occurs.
3. The device according to claim 2 , wherein the processing region comprises binding sites for target components (T) of the fluid.
4. The device according to claim 1 , wherein the blocking zone (BZ, BZ′) extends between opposing walls of the processing chamber, dividing the processing chamber into two disconnected volumes.
5. The device according to claim 1 , wherein the mean distance between magnetic particles (MP, MPB) and/or clusters (CL) of magnetic particles in the blocking zone (BZ, BZ′) is less than or equal to the mean diameter of the interfering particles (C).
6. The device according to claim 1 , wherein the blocking zone impedes migration of the interfering particles by maintaining distances between the magnetic particles (MP, MPB) and/or the clusters (CL) of magnetic particles through which interfering particles can not pass.
7. A device comprising:
a processing chamber that receives a fluid with target components and interfering particles, the processing chamber comprising:
a detection surface comprising at least one binding site for binding the target components; and
a blocking zone formed by distributing magnetic particles for physically impeding the interfering particles in the fluid for filtering, thereby controlling distribution of the interfering particles within the processing chamber during processing of the fluid to reduce interference caused by the interfering particles; and
a magnetic field generator that generates a magnetic field for distributing the magnetic particles to form the blocking zone within the processing chamber.
8. The device of claim 7 , wherein the mean distance between the magnetic particles and/or clusters of the magnetic particles of the blocking zone is less than or equal to about five times the mean diameter of the interfering particles.
9. The device of claim 7 , wherein the mean distance between the magnetic particles and/or clusters of the magnetic particles of the blocking zone is less than or equal to the mean diameter of the interfering particles.