Hardenable antimicrobial composition
View Patent ↗The present disclosure provides antimicrobial compositions including a polyhaloolefin polymer, a cationic antimicrobial agent, and a vehicle that includes a plasticizer and a heat stabilizer. The cationic antimicrobial agent can be partially soluble in the vehicle. The present disclosure also provides for articles formed from the composition, with cationic antimicrobial agent incorporated throughout the polymer matrix, as well as methods of manufacturing the composition.
1. A hardenable polyhaloolefin composition, the composition comprising:
a polyvinyl chloride polymer;
a cationic antimicrobial agent; and
a vehicle comprising a plasticizer and a heat stabilizer package, wherein the cationic antimicrobial is dissolved or dispersed in the vehicle to a concentration of at least 0.5 wt. % based on the total weight of the vehicle.
2. The composition of claim 1 , wherein the cationic antimicrobial agent comprises at least one of a quaternary ammonium, a polymeric cationic amine, and a biguanide, wherein the cationic antimicrobial agent is present at a concentration of at least about 0.1 wt. % and no greater than about 10 wt. %, based on the total weight of the composition.
3. The composition of claim 1 , wherein the heat stabilizer package comprises a primary heat stabilizer, wherein the primary heat stabilizer comprises an alkyl carboxylate salt of zinc, calcium, barium, strontium, magnesium, tin, quaternary amine, or combinations thereof.
4. The composition of claim 3 , wherein the primary heat stabilizer comprises zinc dioctoate, wherein the zinc dioctoate is present at a concentration of no greater than about 5 wt. % and at least about 0.5 wt. %, based on the total weight of the composition and wherein the primary heat stabilizer is present at a concentration at least equal to the concentration of the cationic antimicrobial agent.
5. An article comprising:
an exposed surface at least partially formed from a hardened antimicrobial composition, the composition comprising:
a polyhaloolefin polymer;
a heat stabilizer package;
a plasticizer; and
a cationic antimicrobial agent incorporated throughout the polyhaloolefin polymer, wherein the cationic antimicrobial is dissolved or dispersed in the vehicle to a concentration of at least 0.5 wt. % based on the total weight of the heat stabilizer package and the plasticizer.
6. The article of claim 5 , wherein the article is a medical article.
7. The article of claim 5 , wherein the cationic antimicrobial agent comprises at least one of a small molecule quaternary ammonium, a polymeric cationic amine, and a biguanide, and wherein the cationic antimicrobial agent is present at a concentration of at least about 0.1 wt. % and no greater than about 10 wt %, based on the total weight of the composition.
8. The article of claim 5 wherein the heat stabilizer package comprises a primary heat stabilizer, and wherein the primary heat stabilizer comprises a salt of zinc, tin, calcium, barium, strontium, magnesium, quaternary amine, or combinations thereof, and wherein the primary heat stabilizer is present in the composition at a concentration at least equal to the concentration of the cationic antimicrobial agent.
9. The article of claim 5 , wherein the cationic antimicrobial agent regenerates at the surface of the article after customary use.
10. The composition of claim 3 , wherein the heat stabilizer package further comprises a secondary heat stabilizer comprising, an aryl or alkyl phosphite.