Protein kinase inhibitors

1. A compound of Formula 1:

wherein

R is selected from the group consisting of:

1) hydrogen,

2) alkyl,

3) heteroalkyl,

4) carbocyclyl,

5) heterocyclyl,

wherein the alkyl, heteroalkyl, carbocyclyl and heterocyclyl may be further substituted;

Y is

E is oxygen,

Z is

wherein Y-E-Z-W is

X 1 and X 2 are independently selected from hydrogen and halogen;

n is an integer from 0 to 2;

m is an integer from 0 to 2;

m′ is an integer from 0 to 2;

W is selected from the group consisting of:

1) halogen,

2) aralkyl,

3) heteroaralkyl,

4) —OR 3 ,

5) —OC(O)R 4 ,

6) —OC(O)NR 5 R 6 ,

7) —CH 2 O—R 4 ,

8) —NR 5 R 6

9) —NR 2 C(O)R 4 ,

10) —NR 2 S(O) n R 4 ,

11) —NR 2 C(O)NR 5 R 6 ,

wherein the aralkyl and heteraralkyl may be further substituted;

R 2 is selected from the group consisting of hydrogen and alkyl;

R 3 is selected from the group consisting of substituted alkyl, unsubstituted alkyl, alkenyl, alkynyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, aralkyl, and heteroaralkyl;

R 4 is selected from the group consisting of substituted alkyl, unsubstituted alkyl, alkenyl, alkynyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl; and

R 5 and R 6 are (i) independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, heteroalkyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl; or

(ii) fused to form a 3 to 8 membered heterocyclyl ring system; or

a pharmaceutically acceptable salt, solvate or solvate of a salt thereof.

2. The compound according to claim 1 , wherein W is —OR′ and R 3 is selected from the group consisting of substituted aralkyl, unsubstituted aralkyl, substituted heteroaralkyl and/or unsubstituted heteroaralkyl.

3. The compound according to claim 1 , wherein R is selected from the group consisting of:

4. The compound according to claim 1 , wherein Z is selected from the group consisting of:

5. The compound according to claim 2 , wherein W is selected from the group consisting of:

6. The compound according to claim 1 selected from the group consisting of:

7. A pharmaceutical composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt, or solvate thereof, and at least one pharmaceutically acceptable excipient.