IP Library › Granted Patent US 9,376,432
Granted Patent B2
US 9,376,432 · App. 14/414,209 · Granted Jun 28, 2016

Use of VEGFR-3 inhibitors for treating hepatocellular carcinoma

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Quick Facts
Patent No.
US 9,376,432
App. No.
14/414,209
Granted
Jun 28, 2016
Kind
B2
Abstract

This invention is related to the use of inhibitors of vascular endothelial growth factor receptor 3 for treating hepatocellular carcinoma.

Claims (7)

1. A method of treating hepatocellular carcinoma comprising administering to a patient in need thereof a pharmaceutically effective amount of a compound of formula (I),

or a pharmaceutically acceptable salt thereof,

wherein R is a methoxy or hydroxyl group.

2. The method according to claim 1 , wherein R is a methoxy group.

3. The method according to claim 1 , wherein R is a hydroxyl group.

4. The method according to any one of claims 1 and 2 , wherein the compound of formula (I) is 2-amino-1-ethyl-7-((3R)-3-hydroxy-4-methoxy-3-methyl-but-1-ynyl)-3-(1H-imidazol-2-yl)-1H-[1,8]-naphthyridin-4-one.

5. The method according to any one of claims 1 and 3 , wherein the compound of formula (I) is 2-amino-7-((3R)3,4-dihydroxy-3-methyl-but-1-ynyl)-1-ethyl-3-(1H-imidazol-2-yl)-1,8-naphthyridin-4(1H)-one.

Assignments (2)
CHANGE OF ADDRESS Recorded Jul 3, 2024
From: SANOFI
To: SANOFI
Reel/Frame 068105/0767 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 24, 2015
From: ALAM, ANTOINE; BLANC, ISABELLE
To: SANOFI
Reel/Frame 035014/0609 →