Method to treat or prevent herpesvirus infections

1. A method of reducing the extent of a herpesvirus infection of a subject, comprising prophylactically administering to the subject an amount of an inhibitor of Akt effective to reduce the extent of a herpesvirus infection in a subject.

2. The method of any of claim 1 , wherein the herpesvirus is a herpes simplex virus, a cytomegalovirus, an Epstein Barr virus, a human herpesvirus-6, a human herpesvirus-7, a Varicella zoster virus, or a Kaposi's sarcoma-associated herpesvirus.

3. The method of claim 1 , wherein the herpesvirus is a herpes simplex virus-1 or is herpes simplex virus-2.

4. The method of claim 1 , wherein the subject has neonatal encephalitis, sporadic encephalitis, and/or genital ulcerative disease.

5. The method of claim 1 , wherein the subject is at risk of neonatal encephalitis or of sporadic encephalitis.

6. The method of claim 1 , wherein the subject has a herpesvirus infection that is resistant to acyclovir and/or valacyclovir.

7. The method of claim 1 , wherein the subject has neurological symptoms from a herpesvirus infection.

8. The method of claim 1 , wherein the subject has a herpesvirus infection, and the method inhibits further herpesvirus infection in the subject.

9. The method of claim 8 , wherein the subject has a latent herpesvirus infection.

10. The method of claim 1 , wherein the inhibitor of Akt, or the inhibitor of a viral glycoprotein B, C, D or H, is applied systemically to the subject.

11. The method of claim 1 , wherein the inhibitor of Akt is applied to topically the subject.

12. The method of claim 1 , wherein the inhibitor of Akt is applied to a mucous membrane of the subject.

13. The method of claim 1 , wherein the inhibitor of Ak is applied to a genitalial surface of the subject.

14. The method of claim 1 , wherein the inhibitor of Akt is a small organic molecule of 2,000 daltons or less.