Treatment of helicobacter pylori infections
Methods of treating infections due to Helicobacter pylori ( H. pylori ), in particular in subjects having a peptic ulcer, are disclosed where the methods comprise administering to the subject an inhibitor of H. pylori MTAN (5′-methylthioadenosine nucleosidase) having the structure of formula (I)
1. A compound selected from the group consisting of
or a pharmaceutically acceptable salt thereof, or an ester thereof.
2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
3. A method of treating a Helicobacter pylori ( H. pylori ) infection in a subject in need thereof comprising administering to the subject a compound of claim 1 in an amount effective to inhibit growth of H. pylori.
4. The method of claim 3 , wherein the subject has a peptic ulcer.
5. The method of claim 3 , wherein the subject has a gastric ulcer or a duodenal ulcer.
6. The method of claim 3 , wherein the compound is administered orally.