Aggrecanase inhibitors
View Patent ↗The present invention provides compounds having the formula: wherein R 1 is selected from methyl, ethyl, propyl, cyclopropyl, and dimethyl, or a pharmaceutically acceptable salt thereof, along with methods and intermediates for their preparation, and uses thereof.
1. A compound having the formula:
wherein R 1 is selected from methyl, ethyl, propyl, dimethyl, and cyclopropyl, or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 having the formula:
or a pharmaceutically acceptable salt thereof.
3. The compound according to claim 1 having the formula:
or a pharmaceutically acceptable salt thereof.
4. The compound according to claim 3 having the formula:
or a pharmaceutically acceptable salt thereof.
5. The compound according to claim 1 having the formula:
or a pharmaceutically acceptable salt thereof.
6. A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one of a pharmaceutically acceptable carrier, excipient, or diluent.
7. The pharmaceutical composition of claim 6 , wherein said pharmaceutical composition is adapted for oral administration.
8. A method of treating arthritis in a patient in need thereof, said method comprising administering an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, to said patient.
9. The method of claim 8 , wherein said patient is administered at least one additional active agent.
10. The method of claim 8 , wherein said patient is a human.
11. The method of claim 8 , wherein said patient is a dog.
12. The method of claim 8 , wherein said administration is oral administration.
13. A method of inhibiting cartilage erosion in a patient in need thereof, said method comprising administering an effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof, to said patient.
14. The method of claim 13 , wherein said patient is administered at least one additional active agent.
15. The method of claim 13 , wherein said patient is a human.
16. The method of claim 13 , wherein said patient is a dog.
17. The method of claim 13 , wherein said administration is oral administration.