CHLORHEXIDINE GLUCONATE COMPOSITIONS, RESIN SYSTEMS AND ARTICLES
Compositions containing chlorhexidine gluconate solubilized in hydrophobic vehicles are described. Resin systems containing such chlorhexidine gluconate compositions, including adhesives and articles incorporating such resin systems, including medical articles such as drapes are also described.
1 . A composition comprising chlorhexidine gluconate solubilized in a hydrophobic vehicle having a hydrophilic-lipophilic balance of no greater than 10 as determined using the HLB Method.
2 . The composition of claim 1 , wherein the hydrophobic vehicle comprises two proximate hydrogen-bonding groups, wherein at least one of the hydrogen-bonding groups is a hydrogen donor.
3 . The composition of claim 1 , wherein the hydrophobic vehicle comprises an ester group.
4 . The composition of claim 3 , wherein the hydrophobic vehicle comprises a monoacylglycerol.
5 . The composition of claim 4 , wherein the alkyl group of the monoacylglycerol is a C8 to C18 alkyl group.
6 . The composition of claim 5 , wherein the monoacylglycerol is selected from the group consisting of glycerol monocaprylate, glycerol monolaurate, glycerol monoisostearate, glycerol monooleate, and combinations thereof.
7 . The composition of claim 1 , wherein the hydrophobic vehicle comprises an ether group.
8 . The composition of claim 7 , wherein the hydrophobic vehicle comprises dipropylene glycol.
9 . The composition of claim 7 , wherein the hydrophobic vehicle comprises a glyceryl monoalkyl ether.
10 . The composition of claim 9 , wherein the glyceryl monoalkyl ether is ethylhexylglycerin.
11 . The composition of claim 1 , wherein the hydrophobic vehicle comprises an alcohol having proximate hydroxyl groups.
12 . The composition of claim 11 , wherein the alcohol is selected from the group consisting of 1,2-octane diol, 1,2-decane diol, and combinations thereof.
13 - 14 . (canceled)
15 . The composition according to claim 1 , wherein the composition comprises no greater than 0.1 parts by weight water per 1 part by weight chlorhexidine gluconate.
16 . The composition according to claim 1 , further comprising a resin system comprising a polymer.
17 . The composition of claim 16 , wherein the resin system comprises a hydrophobic phase, wherein the hydrophobic vehicle plasticizes the hydrophobic phase.
18 . The composition of claim 16 , wherein the polymer comprises an acrylate polymer.
19 . The composition of claim 16 , wherein the polymer comprises a block copolymer polymer.
20 . The composition according to claim 16 , wherein the resin system is a pressure sensitive adhesive.
21 - 22 . (canceled)
23 . An article comprising a substrate and the composition according to claim 1 bonded to at least a portion of a surface of the substrate.
24 - 26 . (canceled)
27 . The article according to claim 23 , wherein the article is a medical article.
28 . The article according to claim 27 , where in the medical article is a drape.
29 . The article according to claim 27 , where in the medical article is a dressing.