Formulations Comprising Idebenone, N-Acetyl-S-Farnesyl-L-Cysteine and Ergothioneine and Uses Thereof
Compositions that mitigate damage caused by environmental stressors are provided. The stressors include, but are not limited to, damage caused by ultra-violet radiation. The compositions comprise an effective amount of idebenone or a derivative thereof, N-acetyl-S-farnesyl-L-cysteine or a pharmaceutically acceptable salt or ester thereof and ergothioneine or a pharmaceutically acceptable salt or ester thereof. In some embodiments these compositions are applied topically to a person's skin.
1 . A formulation comprising: idebenone or a derivative thereof, N-acetyl-S-farnesyl-L-cysteine or a pharmaceutically acceptable salt or ester thereof and ergothioneine or a pharmaceutically acceptable salt or ester thereof.
2 . The formulation of claim 1 , wherein
(a) the idebenone or the derivative thereof is present in an amount of 0.0001-5.0 wt. % based on the total weight of the formulation;
(b) the N-acetyl-S-farnesyl-L-cysteine or the pharmaceutically acceptable salt or ester thereof is present in an amount of 0.0001-10.0 wt. % based on the total weight of the formulation; and
(c) the ergothioneine or the pharmaceutically acceptable salt or ester thereof is present in an amount of 0.0001-10.0 wt. % based on the total weight of the formulation.
3 . The formulation of claim 2 , wherein the idebenone or the derivative thereof is:
4 . A method for preventing a skin change, said method comprising applying a topical preparation to the skin, the preparation comprising an effective amount of idebenone or a derivative thereof, N-acetyl-S-farnesyl-L-cysteine or a pharmaceutically acceptable salt or ester thereof and ergothioneine or a pharmaceutically acceptable salt or ester thereof.
5 . A method of inhibiting UV induction of pro-inflammatory cytokines, said method comprising administering a formulation of claim 1 to an organism, wherein said organism has been exposed to UV radiation.
6 . The method of claim 5 , wherein said administering is by topically applying the formulation to the organism.
7 . The method of claim 6 , wherein the formulation is applied to a region of skin of the organism.
8 . The method of claim 5 , wherein the cytokines comprise IL-6 or TNF-α or a combination thereof.
9 . A method for reducing sun burn cell formation, said method comprising administering an effective amount of a formulation of claim 1 to an organism, wherein said organism has been exposed to UV radiation.
10 . A method for treating inflammation comprising administering an effective amount of a formulation according to claim 1 to a person in need thereof.
11 . A method for repairing DNA damage comprising administering an effective amount of a formulation according to claim 1 to a person in need thereof.
12 . A method for treating human skin comprising topically applying to the human skin an effective amount of a composition comprising the formulation of claim 1 , wherein said treating comprises scavenging for free radicals.
13 . A method for treating human skin comprising topically applying to the human skin an effective amount of a composition comprising the formulation of claim 1 , wherein said treating comprises an anti-oxidant effect.
14 . The method according to claim 13 , wherein said anti-oxidant effect protects against skin aging.
15 . A method for treating human skin comprising topically applying to the human skin an effective amount of a composition comprising the formulation of claim 1 , wherein said treating mitigates against at least one of UV-induced pro-inflammatory cytokines and MMP production.
16 . The method according to claim 15 , wherein said treating mitigates against both of UV-induced pro-inflammatory cytokines and MMP production.