Oligomer-containing benzamide-based compounds

1. A compound having the following structure:

wherein:

R 2 is lower alkyl;

(a) is an integer in the range of from 1 to 4 inclusive;

Y is either O or S;

R 3 is lower alkyl;

R 4 is selected from the group consisting of hydrogen, halo, lower alkoxy, amino, and lower alkylamino;

R 5 is selected from the group consisting of hydrogen, halo, lower alkoxy, amino, and lower alkylamino;

R 6 is selected from the group consisting of hydrogen, halo, lower alkoxy, amino, and lower alkylamino;

X is a stable or releasable linkage; and

POLY is a water-soluble, non-peptidic oligomer having a number of repeating monomers in the range of from 2 to 30,

and pharmaceutically acceptable salts thereof.

2. The compound of claim 1 , wherein the linkage is a stable linkage.

3. The compound of claim 1 , wherein the linkage is a degradable linkage.

4. The compound of claim 1 , wherein the linkage is selected from the group consisting of amine, urea, carbamate and ether.

5. The compound of claim 1 , wherein the weight average molecular weight of the water-soluble, non-peptidic oligomer is less than 400 Daltons.

6. The compound of claim 1 , having the following structure:

wherein n is in the range of 2 to 30, and pharmaceutically acceptable salts thereof.

7. The compound of claim 1 , wherein the water-soluble, non-peptidic oligomer is a poly(alkylene oxide).

8. The compound of claim 7 , wherein the poly(alkylene oxide) is a poly(ethylene oxide).

9. The compound of claim 1 , wherein the water-soluble, non-peptidic oligomer has a number of repeating monomers in the range of from 2 to 10.

10. The compound of claim 7 , wherein the poly(alkylene oxide) includes an alkoxy or hydroxyl end-capping moiety.

11. A composition comprising a compound of claim 1 , and (ii) optionally, a pharmaceutically acceptable excipient.

12. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form.