Pyrrolobenzodiazepine—anti-PSMA antibody conjugates
Conjugates of an antibody that binds to PSMA with PBD dimers.
1. A conjugate of formula ConjE:
where Ab is an antibody that binds to PSMA, the antibody comprising a VH domain having the amino acid sequence according to SEQ ID NO: 3 and a VL domain having the amino acid sequence according to SEQ ID NO: 4; and wherein the drug loading of drugs to antibody is an integer from 1 to about 8.
2. The conjugate according to claim 1 wherein the antibody is an intact antibody.
3. The conjugate according to claim 1 wherein the antibody is humanised, deimmunised or resurfaced.
4. The conjugate according to claim 1 , wherein the drug loading of drugs to antibody is 1, 2, 3, or 4.
5. A mixture of conjugates according to claim 4 , wherein the average value of the drug loading of drugs to antibody is about 2 to about 5.
6. The conjugate according to claim 1 , wherein said conjugate comprises ConjE for use in treating a PSMA overexpressing cancer.
7. A pharmaceutical composition comprising the conjugate of claim 1 and a pharmaceutically acceptable diluent, carrier or excipient.
8. The pharmaceutical composition of claim 7 , further comprising a therapeutically effective amount of a chemotherapeutic agent.
9. A method of treating cancer comprising administering to a patient the pharmaceutical composition of claim 7 .
10. The method of claim 9 wherein the patient is administered a chemotherapeutic agent, in combination with the conjugate.