IP Library › Granted Patent US 10,736,903
Granted Patent B2
US 10,736,903 · App. 14/434,818 · Granted Aug 11, 2020

Pyrrolobenzodiazepine-anti-PSMA antibody conjugates

Inventors: Patricius Hendrikus Cornelis Van Berkel (Lausanne, CH); Philip Wilson Howard (London, GB)
Assignee: MEDIMMUNE LIMITED
A61K31/551A61K45/06A61K47/6869C07K16/18C07K2317/24C07K2317/56
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Quick Facts
Patent No.
US 10,736,903
App. No.
14/434,818
Granted
Aug 11, 2020
Kind
B2
Abstract

Conjugates of an antibody that binds to PSMA with PBD dimers.

Claims (7)

1. A conjugate of formula ConjE:

wherein Ab is an antibody that binds to PSMA and comprises a VH domain having the amino acid sequence of SEQ ID NO.1 and a VL domain having the amino acid sequence of SEQ ID NO. 9, and wherein the drug loading is from about 1 to 8.

2. The conjugate according to claim 1 , wherein the antibody is an intact antibody.

3. The conjugate according to claim 1 , wherein the antibody is humanised, deimmunised, or resurfaced.

4. The conjugate according to claim 1 , wherein the drug loading is 1, 2, 3, or 4.

5. A pharmaceutical composition comprising the conjugate of claim 1 , and a pharmaceutically acceptable diluent, carrier, or excipient.

6. The pharmaceutical composition of claim 5 , further comprising a therapeutically effective amount of a chemotherapeutic agent.

Assignments (6)
PATENT SECURITY AGREEMENT Recorded Dec 27, 2022
From: ADC THERAPEUTICS SA
To: OWL ROCK OPPORTUNISTIC MASTER FUND I, L.P.
Reel/Frame 062228/0763 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 11, 2019
From: ADC THERAPEUTICS SA
To: MEDIMMUNE LIMITED
Reel/Frame 050339/0591 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY ADDRESS PREVIOUSLY RECORDED AT REEL: 039791 FRAME: 0157. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Sep 22, 2016
From: HOWARD, PHILIP WILSON
To: MEDIMMUNE LIMITED
Reel/Frame 040107/0618 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2016
From: VAN BERKEL, PATRICIUS HENDRIKUS CORNELIS
To: A.T. DEVELOPMENT SWITZERLAND SÀRL
Reel/Frame 039790/0855 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2016
From: A.T. DEVELOPMENT SWITZERLAND SÀRL
To: ADC THERAPEUTICS S.A.
Reel/Frame 039790/0982 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 20, 2016
From: HOWARD, PHILIP WILSON
To: MEDIMMUNE LIMITED
Reel/Frame 039791/0157 →
Cited By (2)
US 12,630,838 US 12,637,690