IP Library Granted Patent US 9,493,446
Granted Patent B2
US 9,493,446 · App. 14/434,997 · Granted Nov 15, 2016

Orexin receptor antagonists which are [

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Quick Facts
Patent No.
US 9,493,446
App. No.
14/434,997
Granted
Nov 15, 2016
Kind
B2
Abstract

The present invention relates to [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives of formula (I) wherein R, and the rings A 1 A 2 and A 3 are as described in the description, to pharmaceutically acceptable salts thereof, to their preparation, to pharmaceutical compositions containing one or more compounds of formula (I), and to their use as pharmaceuticals, especially to their use as orexin receptor antagonists.

Claims (451)

1. A compound of formula (I)

wherein the carbon atom at position 2 of the pyrrolidine ring is in absolute (S)-configuration;

R represents hydrogen or methyl;

ring A 3 represents a mew di-substituted 5-membered heteroarylene ring containing one, two or three heteroatoms; wherein at least one of said heteroatoms is nitrogen, and the remaining is/are independently selected from oxygen, sulfur and nitrogen;

ring A 2 represents aryl or 5- to 10-membered heteroaryl; wherein said aryl or 5- to 10-membered heteroaryl is independently unsubstituted, or mono-, di-, or tri-substituted; wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 3-6 )cycloalkyl, halogen, cyano, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, hydroxy, (C 1-4 )alkoxy-(C 1-3 )alkyl, hydroxy-(C 1-3 )alkyl, —CO—(C 1-4 )alkyl, and (C 3-6 )cycloalkyl-oxy-; or

ring A 2 represents a 2,3-dihydro-benzo[1,4]dioxinyl, a 2,3-dihydro-benzofuranyl, or a benzo[1,3]dioxolyl group optionally di-substituted with fluoro; and

ring A 1 represents phenyl or 5- or 6-membered heteroaryl, wherein said phenyl or 5- or 6-membered heteroaryl independently is mono-, di-, or tri-substituted; wherein

one of said substituents is attached in ortho-position to the point of attachment of A 1 to the rest of the molecule; wherein said substituent is phenyl or 5- or 6-membered heteroaryl; wherein said phenyl or 5- or 6-membered heteroaryl substituent is independently unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy;

and the other of said substituents, if present, is/are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy;

provided that ring A 1 is not isoxazol-4-yl, substituted in position 5 with (C 1-4 )alkyl, attached to the rest of the molecule at position 4, and carrying said further ortho-substitutent in position 3;

with the exception of the compound (1,1′-biphenyl)-2-yl-{(S)-2-[3-(3-pyridinyl)-1H-1,2,4-triazol-5-yl]-1-pyrrolidinyl}-methanone;

or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 ; wherein the ring A 3 is a meta di-substituted 5-membered heteroarylene ring selected from the group consisting of oxadiazol-diyl, triazol-diyl, isoxazol-diyl, oxazol-diyl, thiazol-diyl, pyrazol-diyl, imidazol-diyl, isothiazol-diyl, and thiadiazol-diyl;

or a pharmaceutically acceptable salt thereof.

3. The compound according to claim 1 ; which is also a compound of the formula (IV):

wherein the carbon atom at position 2 of the pyrrolidine ring is in absolute (S)-configuration;

wherein

R represents hydrogen or methyl;

the ring

represents a meta di-substituted 5-membered heteroarylene ring containing one, two or three heteroatoms at any of the positions X 1 , X 2 , X 3 , and/or X 4 ; wherein at least one of said heteroatoms is nitrogen, and the remaining, if present, is/are independently selected from oxygen, sulfur and nitrogen;

Ar 2 represents phenyl or 5- to 10-membered heteroaryl; wherein said phenyl or 5- to 10-membered heteroaryl is independently unsubstituted, or mono-, di-, or tri-substituted; wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 3-6 )cycloalkyl, halogen, cyano, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, hydroxy, (C 1-4 )alkoxy-(C 1-3 )alkyl, hydroxy-(C 1-3 )alkyl, —CO—(C 1-4 )alkyl, and (C 3-6 )cycloalkyl-oxy-; or

Ar 2 represents a 2,3-dihydro-benzo[1,4]dioxinyl, a 2,3-dihydro-benzofuranyl, or a benzo[1,3]dioxolyl group optionally di-substituted with fluoro;

(R x ) m represents one or two optional substituents independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy; and

Ar 4 represents phenyl or 5- or 6-membered heteroaryl; wherein said phenyl or 5- or 6-membered heteroaryl substituent is independently unsubstituted, mono-, di-, or tri-substituted, wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxyl;

with the exception of the compound (1,1′-biphenyl)-2-yl-{(S)-2-[3-(3-pyridinyl)-1H-1,2,4-triazol-5-yl]-1-pyrrolidinyl}-methanone;

or a pharmaceutically acceptable salt thereof.

4. The compound according to claim 3 ; wherein the ring

represents a group selected from the group consisting of [1,2,4]oxadiazol-3,5-diyl, [1,2,4]triazol-3,5-diyl, [1,2,4]triazol-1,3-diyl, 1H-pyrazol-3,5-diyl, imidazol-2,4-diyl, isoxazol-3,5-diyl, oxazol-2,4-diyl, oxazol-2,5-diyl, thiazol-2,4-diyl, [1,3,4]thiadiazol-2,5-diyl, and [1,3,4]oxadiazol-2,5-diyl;

or a pharmaceutically acceptable salt thereof.

5. The compound according to claim 4 ; wherein

Ar 4 is selected from the group consisting of unsubstituted triazolyl; unsubstituted pyrazolyl; unsubstituted oxazolyl; oxadiazolyl mono-substituted with methyl; unsubstituted pyridyl; unsubstituted pyrimidinyl; and unsubstituted or mono-substituted phenyl wherein the substituent is selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, and halogen; and

(R x ) m represents one or two optional substituents independently selected from (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy;

or a pharmaceutically acceptable salt thereof.

6. The compound according to claim 4 ; wherein

Ar 4 is unsubstituted triazolyl; or unsubstituted pyrimidinyl; and

(R x ) m represents one or two substituents independently selected from (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, cyano, (C 1-3 )fluoroalkyl, and (C 1-3 )fluoroalkoxy;

or a pharmaceutically acceptable salt thereof.

7. The compound according to claim 3 ; wherein the group

is a group independently selected from the following groups A) to D):

or a pharmaceutically acceptable salt thereof.

8. The compound according to claim 2 ; wherein the ring A 2 represents

phenyl which is unsubstituted, or mono-, di-, or tri-substituted; wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 3-6 )cycloalkyl, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy; hydroxy, (C 1-4 )alkoxy-(C 1-3 )alkyl, and hydroxy-(C 1-3 )alkyl; or

a 2,3-dihydro-benzo[1,4]dioxinyl, a 2,3-dihydro-benzofuranyl, or a benzo[1,3]dioxolyl group which is optionally di-substituted with fluoro; or

6-membered heteroaryl; wherein said heteroaryl is independently unsubstituted, or mono-, or di-substituted; wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 3-6 )cycloalkyl, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy, and (C 3-6 )cycloalkyl-oxy-; or

8- to 10-membered heteroaryl; wherein said heteroaryl is independently unsubstituted, or mono-substituted; wherein the substituent is independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, and —CO—(C 1-4 )alkyl;

or a pharmaceutically acceptable salt thereof.

9. The compound according to claim 2 ; wherein ring A 2 represents

phenyl which is unsubstituted, or mono-, di-, or tri-substituted; wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, (C 3-6 )cycloalkyl, halogen, (C 1-3 )fluoroalkyl, (C 1-3 )fluoroalkoxy; hydroxy, (C 1-4 )alkoxy-(C 1-3 )alkyl, and hydroxy- (C 1-3 )alkyl; or

2,3-dihydro-benzo[1,4]dioxin-5-yl, 2,3-dihydro-benzofuran-7-yl, benzo[1,3]dioxol-4-yl, benzo[1,3]dioxol-5-yl, or 2,2-difluoro-benzo[1,3]dioxol-5-yl; or

5- or 6-membered heteroaryl selected from pyridyl, pyrazolyl, and pyrazinyl; wherein said heteroaryl is independently mono-, or di-substituted; wherein the substituents are independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, halogen, (C 1-3 )fluoroalkoxy, and (C 3-6 )cycloalkyl-oxy-; or

8- to 10-membered heteroaryl selected from indolyl, pyrrolopyridyl, imidazothiazolyl, and indazolyl; wherein said heteroaryl is independently unsubstituted, or mono-substituted; wherein the substituent is independently selected from the group consisting of (C 1-4 )alkyl, (C 1-4 )alkoxy, and —CO—(C 1-4 )alkyl;

or a pharmaceutically acceptable salt thereof.

10. The compound according to claim 1 ; wherein the group A 3 -A 2 represents a group

independently selected from the following groups A) to H):

A): [1,2,4]oxadiazol-3,5-diyl groups selected from the groups:

B): [1,2,4]oxadiazol-3,5-diyl groups selected from the groups:

C): oxazol-2,4-diyl groups selected from:

D): oxazol-2,5-diyl groups selected from:

E): isoxazol-3,5-diyl groups selected from the groups:

F): [1,2,4]triazol-3,5-diyl groups selected from the groups:

G): imidazol-2,4-diyl groups selected from the groups:

H): 1H-[1,2,4]triazol-1,3-diyl groups selected from:

or a pharmaceutically acceptable salt thereof.

11. The compound according to claim 1 selected from the group consisting of:

{(S)-2-[3-(2-Cyclopropyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(1H-Indol-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2,3-Dihydro-benzo[,4]dioxin-5-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(1H-Indol-7-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(1-Methyl-1H-pyrrolo [2,3-b]pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(1-Methyl-1H-indol-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Isopropoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

1-(3-{5-[(S)-1-(5-Methyl-2-[1,2,3]triazol-2-yl-benzoyl)-pyrrolidin-2-yl]-[1,2,4]oxadiazol-3-yl}-indol-1-yl)-ethanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methyl-biphenyl-2-yl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methoxy-biphenyl-2-yl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-oxazol-2-yl-phenyl)-methanone;

(4-Methyl-biphenyl-2-yl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Methyl-2-pyrazol-1-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Methyl-2-pyridin-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(2-Fluoro-3-methyl-6-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4-Methoxy-biphenyl-2-yl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-pyrazol-1-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

[3-Fluoro-2-(2H-pyrazol-3-yl)-phenyl]-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Methyl-2-oxazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Difluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Difluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-pyridin-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-oxazol-2-yl-phenyl)-methanone;

(4, 5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Ethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4, 5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Ethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[l 1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Ethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Ethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4, 5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-isoxazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-isoxazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[4-(2-trifluoromethoxy-phenyl)-oxazol-2-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-[1,3,4]oxadiazol-2-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Ethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Fluoro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethyl-phenyl)-[l 1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethyl-phenyl)-[l 1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2,3-Dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2,3-Dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2,5-Dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2,3-dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2,5-dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(5-methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-chloro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-pyridin-3-yl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Ethoxy-pyridin-3-yl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-pyridin-3-yl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-pyridin-3-yl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-pyridin-3-yl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(4-chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Methoxy-phenyl)-1H-imidazol-2-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethoxy-phenyl)-1H-imidazol-2-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-1H-imidazol-2-yl]-pyrrolidin-1-yl}-methanone;

(4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-1H-imidazol-2-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Ethoxy-phenyl)-1H-imidazol-2-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-isoxazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-isoxazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-isoxazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-isoxazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-isoxazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(S)-2-(3-phenyl-[,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(S)-2-(3-m-tolyl-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-methanone;

{(S)-2-[3-(3-Methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3,5-Dimethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2,3-Dimethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(S)-2-(3-o-tolyl-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-methanone;

{(S)-2-[3-(3-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Chloro-3-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Chloro-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Difluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Difluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Methoxymethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[(S)-2-(3-Benzo[1,3]dioxol-4-yl-[1,2,4]oxadiazol-5-yl)-pyrrolidin-1-yl]-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-methyl-3-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Ethoxy-pyridin-4-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2,3-Dimethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(1-Methyl-1H-indol-4-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Fluoro-6-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(1-Methyl-1H-indol-7-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Methyl-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Difluoromethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-chloro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(2-fluoro-3-methyl-6-[1,2,3]triazol-2-yl-phenyl)-methanone;

Biphenyl-2-yl-{(S)-2-[3-(3-chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-pyrazol-1-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-pyridin-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-fluoro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-pyrazol-1-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-2-pyrazol-1-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-pyrazol-1-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-[5-fluoro-2-(2H-pyrazol-3-yl)-phenyl]-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-[3-fluoro-2-(2H-pyrazol-3-yl)-phenyl]-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(3,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(2-oxazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-chloro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-fluoro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4,5-dimethoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

Biphenyl-2-yl-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-m-Tolyl-oxazol-4-yl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(2-[1,2,3]Triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Fluoro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Methoxy-4-methyl-2-pyrazol-1-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

[5-Fluoro-2-(2H-pyrazol-3-yl)-phenyl]-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(3,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(2-Oxazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4, 5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-difluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Difluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Difluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-[3-fluoro-2-(2H-pyrazol-3-yl)-phenyl]-methanone;

{(S)-2-[3-(2-Difluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-pyridin-2-yl-phenyl)-methanone;

(3,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-fluoro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-[3-fluoro-2-(2H-pyrazol-3-yl)-phenyl]-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-pyridin-2-yl-phenyl)-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(2-[1,2,3]triazol-2-yl-4-trifluoromethyl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-fluoro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(3,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(6-methyl-3-[1,2,3]triazol-2-yl-pyridin-2-yl)-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-[3-fluoro-2-(2H-pyrazol-3-yl)-phenyl]-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-fluoro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-fluoro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-[3-fluoro-2-(2H-pyrazol-3-yl)-phenyl]-methanone;

{(S)-2-[3-(2-Ethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-[3-fluoro-2-(2H-pyrazol-3-yl)-phenyl]-methanone;

{(S)-2-[3-(3,4-Dimethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2,4-Dimethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2,5-Dimethyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-pyrimidin-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-pyrimidin-2-yl-phenyl)-methanone;

{(S)-2-[5-(2,3-Dihydro-benzofuran-7-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-fluoro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethoxy-3-fluoro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-fluoro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-fluoro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2,3-Dimethyl-phenyl)-isoxazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3,5-Dimethyl-phenyl)-isoxazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Methoxy-pyridin-3-yl)-isoxazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-isoxazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-isoxazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-[1,3,4]oxadiazol-2-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

[5-(3-Fluoro-phenyl)-2-methyl-thiazol-4-yl]-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-[1,3,4]oxadiazol-2-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-chloro-2-methyl-phenyl)-[1,3,4]oxadiazol-2-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-pyrimidin-2-yl-phenyl)-methanone;

{(S)-2-[3-(2-Ethoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-pyrimidin-2-yl-phenyl)-methanone;

(4-Fluoro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-fluoro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Fluoro-2-methyl-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Ethoxy-pyridin-3-yl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2,3-Dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2,5-Dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2,3-Dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2,5-Dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2,3-dimethyl-phenyl)-[l 1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2,5-dimethyl-phenyl)-[l 1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2,3-dimethyl-phenyl)-[l 1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2,5-dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2,5-Dimethyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(5-Methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(5-Methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(5-methoxy-2-methyl-phenyl)-1 [1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(5-methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(5-Methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(2-Methoxy-5-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(3-fluoro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(5-methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(3-methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-chloro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Methoxy-2-methyl-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(2-[1,2,3]Triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Fluoro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Fluoro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(4-Chloro-6-methoxy-pyridin-2-yl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Methoxy-phenyl)-1H-imidazol-2-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(S)-2-(5-phenyl-isoxazol-3-yl)-pyrrolidin-1-yl]-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(S)-2-(5-phenyl-isoxazol-3-yl)-pyrrolidin-1-yl]-methanone;

(4-Chloro-5-methoxy-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-isoxazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(2-Cyclobutoxy-pyridin-3-yl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(2-Fluoro-3-methoxy-6-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(5-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(4,5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(2-Methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone; and

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-[(S)-2-(1-phenyl-1H-[1,2,4]triazol-3-yl)-pyrrolidin-1-yl]-methanone;

or a pharmaceutically acceptable salt thereof.

12. The compound according to claim 1 selected from the group consisting of:

(5-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4, 5-Dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-4H-[1,2,4]triazol-3-yl]-2-methyl-pyrrolidin-1-yl}-(4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-4H-[1,2,4]triazol-3-yl]-2-methyl-pyrrolidin-1-yl}-(5-chloro-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-4H-[1,2,4]triazol-3-yl]-2-methyl-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone; and

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-4H-[1,2,4]triazol-3-yl]-2-methyl-pyrrolidin-1-yl}-(4-chloro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[5-(3-Chloro-2-methyl-phenyl)-4H-[1,2,4]triazol-3-yl]-2-methyl-pyrrolidin-1-yl}-(5-chloro-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

(5-Methyl-biphenyl-2-yl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone; and

(4-Methyl-biphenyl-2-yl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

or a pharmaceutically acceptable salt thereof.

13. A pharmaceutical composition comprising, as active principle, one or more compounds according to claim 1 , or a pharmaceutically acceptable salt thereof, and at least one therapeutically inert excipient.

14. A method of treatment of diseases or disorders relating to orexinergic disorders selected from sleep disorders, anxiety disorders, addiction disorders, cognitive dysfunctions, mood disorders, or appetite disorders; comprising administering to a patient a pharmaceutically active amount of the compound as defined in claim 1 , or a pharmaceutically acceptable salt thereof.

15. The compound according to claim 3 ; wherein the group

represents a group independently selected from the following groups A) to H):

A): [1,2,4]oxadiazol-3,5-diyl groups selected from the groups:

B): [1,2,4]oxadiazol-3,5-diyl groups selected from the groups:

C): oxazol-2,4-diyl groups selected from:

D): oxazol-2,5-diyl groups selected from:

E): isoxazol-3,5-diyl groups selected from the groups:

F) [1,2,4]triazol-3,5-diyl groups selected from the groups:

G): imidazol-2,4-diyl groups selected from the groups:

H): 1H-[1,2,4]triazol-1,3-diyl groups selected from:

or a pharmaceutically acceptable salt thereof.

16. The compound according to claim 7 ; wherein the group

represents a group independently selected from the following groups A) to H):

A): [1,2,4]oxadiazol-3,5-diyl groups selected from the groups:

B): [1,2,4]oxadiazol-3,5-diyl groups selected from the groups:

C): oxazol-2,4-diyl groups selected from:

D): oxazol-2,5-diyl groups selected from:

E): isoxazol-3,5-diyl groups selected from the groups:

F): [1,2,4]triazol-3,5-diyl groups selected from the groups:

G): imidazol-2,4-diyl groups selected from the groups:

H): 1H-[1,2,4]triazol-1,3-diyl groups selected from:

or a pharmaceutically acceptable salt thereof.

17. The compound according to claim 1 selected from the group consisting of:

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-3-yl]-pyrrolidin-1-yl}-methanone;

(5-Methoxy-4-methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[3-(2-trifluoromethoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-methanone;

{(S)-2-[3-(3-Chloro-2-methyl-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(4,5-dimethyl-2-[1,2,3]triazol-2-yl-phenyl)-methanone;

{(S)-2-[3-(3-Fluoro-2-methoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-pyrrolidin-1-yl}-(5-methoxy-4-methyl-2-pyrimidin-2-yl-phenyl)-methanone;

(4-Methyl-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone; and

(4-Chloro-2-[1,2,3]triazol-2-yl-phenyl)-{(S)-2-methyl-2-[5-(2-trifluoromethoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-pyrrolidin-1-yl}-methanone;

or a pharmaceutically acceptable salt thereof.

18. A method of treatment of diseases or disorders relating to orexinergic disorders selected from sleep disorders, anxiety disorders, addiction disorders, cognitive dysfunctions, mood disorders, or appetite disorders; comprising administering to a patient a pharmaceutically active amount of the compound as defined in claim 11 , or a pharmaceutically acceptable salt thereof.

19. A method of treatment of diseases or disorders relating to orexinergic disorders selected from sleep disorders, anxiety disorders, addiction disorders, cognitive dysfunctions, mood disorders, or appetite disorders; comprising administering to a patient a pharmaceutically active amount of the compound as defined in claim 12 , or a pharmaceutically acceptable salt thereof.

20. A method of treatment of diseases or disorders relating to orexinergic disorders selected from sleep disorders, anxiety disorders, addiction disorders, cognitive dysfunctions, mood disorders, or appetite disorders; comprising administering to a patient a pharmaceutically active amount of the compound as defined in claim 16 , or a pharmaceutically acceptable salt thereof.

21. A method of treatment of diseases or disorders relating to orexinergic disorders selected from sleep disorders, anxiety disorders, addiction disorders, cognitive dysfunctions, mood disorders, or appetite disorders; comprising administering to a patient a pharmaceutically active amount of the compound as defined in claim 17 , or a pharmaceutically acceptable salt thereof.

Assignments (3)
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE ADDRESS PREVIOUSLY RECORDED AT REEL: 042464 FRAME: 0407. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jun 28, 2017
From: ACTELION PHARMACEUTICALS LTD
To: IDORSIA PHARMACEUTICALS LTD
Reel/Frame 043017/0022 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 13, 2017
From: ACTELION PHARMACEUTICALS LTD
To: IDORSIA PHARMACEUTICALS LTD
Reel/Frame 042464/0407 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 6, 2016
From: BOLLI, MARTIN; BOSS, CHRISTOPH; BROTSCHI, CHRISTINE; GUDE, MARKUS; HEIDMANN, BIBIA; SIFFERLEN, THIERRY; WILLIAMS, JODI T
To: ACTELION PHARMACEUTICALS LTD.
Reel/Frame 038201/0931 →