Ocular filtration devices, systems and methods
View Patent ↗A glaucoma drainage device regulator (GDDR) is disclosed which comprises a membrane and a lumen to regulate the flow of aqueous in conjunction with different ocular (e.g., glaucoma) filtering procedures. In connection with aqueous shunting, the GDDR can be placed over the tip of a shunt tube in the anterior chamber, either at the time of initial surgery or also in devices which have been previously implanted. In connection with trabeculectomy, the GDDR can comprise a flange for seating the GDDR at the sclerostomy in trabeculectomy surgery.
1. A glaucoma drainage device regulator, comprising:
a membrane coupled to an opening of a lumen,
wherein the membrane is at an angle of about 30 to about 60 degrees to a longitudinal axis of the lumen,
wherein the membrane is configured to be selectively perforated by a targeted energy source to form and define perforations,
wherein the perforations defined in the membrane increase aqueous flow to lower intraocular pressure, and
wherein the lumen of the glaucoma drainage device regulator is configured to be sealingly coupled around an end of a shunt tube.
2. The glaucoma drainage device regulator of claim 1 , wherein the membrane is coupled to a shunt tube, wherein the angle between the membrane and a cornea of a patient is between about 30 degrees and about 60 degrees, wherein the angle facilitates formation of the perforations by a photodisruptive laser or an ablative laser.
3. The glaucoma drainage device regulator of claim 2 , wherein the lumen is comprised of one or more of silicone, acrylic, PMMA, fluorinated ethylene propylene, stainless surgical steel, shape memory polymers, collamers and PVDF.
4. The glaucoma drainage device regulator of claim 1 , wherein the membrane comprises at least one divider dividing the membrane into specific areas, wherein the specific areas are configured to be independently and selectively perforated.
5. The glaucoma drainage device regulator of claim 1 , wherein the lumen is detachably coupled around the end of the shunt tube.
6. The glaucoma drainage device regulator of claim 1 , wherein the membrane is comprised of PVDF or cellulose.
7. The glaucoma drainage device regulator of claim 6 , wherein a surface of the membrane is color coded, numbered, or has writing or another target to indicate one or more areas to perforate.
8. A glaucoma drainage device regulator system, comprising:
a membrane,
a lumen coupled with the membrane, wherein the membrane is at an angle of about 30 to about 60 degrees to a longitudinal axis of the lumen,
a shunt tube coupled with the lumen, and
a reservoir coupled with the shunt tube,
wherein the lumen is compression fit around an end of the shunt tube,
wherein the membrane prevents aqueous flow,
wherein the glaucoma drainage device regulator system is used in connection with aqueous shunting,
wherein the membrane is configured to be selectively perforated by photodisruptive or ablative laser to form and define perforations, and
wherein the perforations defined in the membrane increase aqueous flow to lower intraocular pressure.
9. The glaucoma drainage device regulator system of claim 8 , wherein the lumen is comprised of one or more of silicone, acrylic, PMMA, fluorinated ethylene propylene, stainless surgical steel, shape memory polymers, collamers and PVDF.
10. The glaucoma drainage device regulator system of claim 8 , wherein the membrane is comprised of PVDF or cellulose.
11. The glaucoma drainage device regulator system of claim 10 , wherein a surface of the membrane is color coded, numbered, or has writing or another target to indicate one or more areas to perforate.
12. The glaucoma drainage device regulator system of claim 8 , wherein the shunt tube comprises a plurality of lumens and a plurality of reservoirs, wherein the membrane comprises a divider that corresponds to the plurality of lumens, and wherein perforations in the membrane direct the flow of aqueous into only one of the plurality of reservoirs.
13. The glaucoma drainage device regulator system of claim 8 , wherein the lumen is detachably coupled around the end of the shunt tube.
14. A method for regulating intraocular pressure, comprising:
providing a previously implanted shunt tube;
implanting a glaucoma drainage device regulator within a pathway for aqueous flow from an anterior chamber, wherein the glaucoma drainage device regulator comprises a membrane coupled to an end of a lumen, wherein the lumen is coupled as a cap around an end of the shunt tube, wherein the membrane is at an angle of about 30 to about 60 degrees to a longitudinal axis of the lumen;
selectively perforating the membrane using a targeted energy source to form and define perforations in the membrane to increase aqueous flow to lower an intraocular pressure within the anterior chamber, and wherein the membrane is configured to be selectively perforated by a targeted energy source;
evaluating the intraocular pressure at a time at least months later to determine if further perforating the membrane is needed to further lower the intraocular pressure.
15. The method of claim 14 , wherein the lumen is configured to couple with a shunt tube and a reservoir, and wherein the method is used in connection with an aqueous shunting procedure.
16. The method of claim 14 , wherein the step of providing a previously implanted shunt tube comprises providing a shunt tube implanted at least months previously.
17. The method of claim 14 , further comprising a flange circumferentially coupled with the lumen, wherein the method is used in connection with a trabeculectomy procedure.
18. The method of claim 17 , wherein the flange is comprised of one or more of silicone, acrylic, PMMA, fluorinated ethylene propylene, stainless surgical steel, shape memory polymers, collamers and PVDF.
19. The method of claim 14 , wherein the membrane is comprised of PVDF or cellulose.
20. The method of claim 19 , wherein a surface of the membrane is color coded, numbered, or has writing or another target to indicate one or more areas to perforate.